Results 111 to 120 of about 5,743 (215)

Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast

, 2015
The organic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are expressed in the basal membrane of the placental syncytiotrophoblast.
Brooks, S., Cleal, J., Hanson, M., Lewis, R., Lofthouse, Emma, O'Kelly, Ita, Poore, K.   +6 more
core   +1 more source

Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate

Marine Drugs, 2019
The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high ...
Yung-Tsung Chau, Hsin-Yuan Chen, Po-Han Lin, Shih-Min Hsia   +3 more
doaj   +1 more source

K2P channels and their protein partners. [PDF]

, 2005
A decade since their discovery, the K2P channels are recognized as pathways dedicated to regulated background leakage of potassium ions that serve to control neuronal excitability. The recent identification of protein partners that directly interact with
Goldstein, Steve AN, Plant, Leigh D, Rajan, Sindhu   +2 more
core   +1 more source

Impact of Viral Inflammation on the Expression of Renal Drug Transporters in Pregnant Rats

Pharmaceutics, 2019
Inflammation impacts the expression and function of drug transporters at term-gestation; however, the impact of inflammation on the expression of drug transporters at mid-gestation is largely unknown.
Navaz Karimian Pour, Eliza R. McColl, Micheline Piquette-Miller   +2 more
doaj   +1 more source

Efficient proximal tubule-on-chip model from hiPSC-derived kidney organoids for functional analysis of renal transporters

iScience
Summary: Renal transporters play critical roles in predicting potential drug-drug interactions. However, current in vitro models often fail to adequately express these transporters, particularly solute carrier proteins, including organic anion ...
Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawa   +7 more
doaj   +1 more source

The effects of Bifidobacterium animalis QC08 on reducing uric acid level and providing renal protection in mice with hyperuricemia

Frontiers in Microbiology
ObjectiveThe present study aimed to investigate the uric acid-lowering effects of Bifidobacterium animalis QC08 and explore its underlying mechanisms.MethodsHyperuricemia (HUA) model in mice was established using potassium oxonate (250 mg/kg) and yeast ...
Huijia Mao, Yang Fan, Fang Tan, Xingyao Long   +3 more
doaj   +1 more source

Solar heating and cooling system design and development [PDF]

Application surveys and performance studies were conducted to determine a solar heating and hot water configuration that could be used in a variety of applications, and to identify subsystem modules that could be utilized in a building block fashion to ...

core   +1 more source

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity [PDF]

, 2016

core   +1 more source

Data base formation and assessment of biotic and abiotic parameters associated with artificial reefs [PDF]

, 1985
There is a critical need for accurate data in order to make decisions regarding the construction, emplacement, and further development of artificial reefs in the State of Florida.
Bortone, Stephen A., Van Orman, Doyal
core  

A Possible Therapeutic Application of the Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease

Cells
The reabsorption of uric acid (UA) is mainly mediated by urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the kidneys. Dotinurad inhibits URAT1 but does not inhibit other UA transporters, such as GLUT9, ATP-binding cassette transporter G2
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama   +4 more
doaj   +1 more source