Results 111 to 120 of about 4,120 (207)

Organic anion transporter 1 (OAT1) involved in renal cell transport of aristolochic acid I

, 2011
Aristolochic acids (AAs) are a family of structurally related nitrophenanthrene carboxylic acids that are present in medicinal herbs such as Aristolochia species.
R Zhang, J Wu, Y Zeng, M Liu, W Peng, X Yu, X Yang   +6 more
core   +1 more source

The effects of Bifidobacterium animalis QC08 on reducing uric acid level and providing renal protection in mice with hyperuricemia

Frontiers in Microbiology
ObjectiveThe present study aimed to investigate the uric acid-lowering effects of Bifidobacterium animalis QC08 and explore its underlying mechanisms.MethodsHyperuricemia (HUA) model in mice was established using potassium oxonate (250 mg/kg) and yeast ...
Huijia Mao, Yang Fan, Fang Tan, Xingyao Long   +3 more
doaj   +1 more source

Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD

Kidney International Reports
Introduction: Furosemide is commonly prescribed to patients with chronic kidney disease (CKD) but may impair the kidney’s excretion of protein-bound uremic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1 and OAT3).
Margaux Costes-Albrespic, Natalia Alencar de Pinho, Islam Amine Larabi, Carolla El Chamieh, Solène M. Laville, Denis Fouque, Maurice Laville, Luc Frimat, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf, Natalia Alencar De Pinho, Dorothée Cannet, Christian Combe, Denis Fouque, Luc Frimat, Aghilès Hamroun, Yves-Edouard Herpe, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Ziad A. Massy, Pascal Morel, Christophe Pascal, Roberto Pecoits-Filho, Joost Schanstra, Bénédicte Stengel, Céline Lange, Oriane Lambert, Marie Metzger   +29 more
doaj   +1 more source

Source provenance and receptor sensitivity in a frozen OAT1 docking benchmark

In Silico Research in Biomedicine
We evaluated how receptor choice, decision thresholds and source provenance affect agreement with retained OAT1 activity labels. A frozen benchmark contained 36 source-linked measurement records, partitioned into 27 TRAIN and nine TEST records.
Bizhi Wei
doaj   +1 more source

Sex-dependent expression of Oat1 and Oat3 in rat cortical kidney slices.

, 2012
Levels of β-actin, Hprt1, Oat1 and Oat3 were analyzed by TaqMan® real-time PCR in total RNA isolated from four male and four female cortical kidney slices.
Birgitta Christina Burckhardt (170394), Waja Wegner (170389), Maja Henjakovic (170401), Gerhard Burckhardt (170397)   +3 more
core   +1 more source

Molecular characterization of the renal organic anion transporter 1

, 2002
Organic anions of diverse chemical structures are secreted in renal proximal tubules. The first step in secretion, uptake of organic anions across the basolateral membrane of tubule cells, is mediated for the polyspecific organic anion transporter 1 ...
Burckhardt, Gerhard, Bahn, A., Wolff, Natascha A.   +2 more
core   +1 more source

Interaction of Human Renal Organic Anion Transporter OAT1 and OAT3 with Flavonoids [PDF]

An antioxidant effect of the flavonoids in food has been widely noticed as it may prevent the oxidative stress-associated chronic diseases including ischemic heart disease and diabetes mellitus.
Ouchi, Motoshi, Ueda, Yoshihiko, Fujita, Tomoe, Abe, Tokuro, Otani, Naoyuki, Anzai, Naohiko, Morita, Asuka   +6 more
core   +1 more source

A plasma concentration of α-ketoglutarate 1 influences the kinetic interaction of ligands with OAT1

, 2014
Despite the importance of extracellular α-ketoglutarate ( 54 αKG) for OAT1 transport in vivo, in vitro studies to assess drug-drug interaction (DDI) potential at OAT1 are conducted in its absence.
Parker, Sonda, Ingraham, Leslie, Renfro, Larry, Hanna, Imad, Vapurcuyan, Arpine, Pelis, Ryan   +5 more
core   +1 more source

In Vivo Regulation of Small Molecule Natural Products, Antioxidants, and Nutrients by OAT1 and OAT3

The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) are drug transporters that are expressed in the kidney, with well-established roles in the in vivo transport of drugs and endogenous metabolites.
Geoffrey Chang, Jeffry C. Granados, Jeremiah D. Momper, Koustav Maity, Patrick Zhang, Kian Falah, Sanjay K. Nigam, Anisha K. Nigam   +7 more
core   +1 more source

In vitro and in silico characterization of the transport of selected perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonic acids by human organic anion transporter 1 (OAT1), OAT2 and OAT3

: Perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkyl sulfonic acids (PFSAs) belong to the group of poly- and perfluoroalkyl substances (PFASs), which may accumulate in humans due to their limited excretion. To provide more insight into the active
Punt, Ans, Koenderink, Jan B., Leenders, Liz, Russel, Frans G. M., Rijkers, Deborah, Noorlander, Annelies, Dellafiora, Luca, Louisse, Jochem, van den Heuvel, Jeroen J. M. W., Pedroni, Lorenzo, Koenderink, J.B., Russel, F.G.M., Louisse, J., Pedroni, L., Noorlander, A., Leenders, L., Punt, A., Dellafiora, L., Heuvel, J.J.M.W. van den, Rijkers, D.   +19 more
core   +1 more source