Results 91 to 100 of about 4,120 (207)
, 2020 Relation between the renal function and the membrane environment where the organic anion transporters Oat1 and Oat3 are localized is scarce. The aim of this study was to examine the Oat1 and Oat3 distribution in different cellular fractions under ...
Nosetto, Evangelina Cecilia +3 more
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.ABSTRACT Renal clearance (CLr) is the net outcome of glomerular filtration, secretion, and reabsorption, which makes the quantitative requirements for net renal secretion difficult to infer from simple clearance models. Using a mechanistic kidney model (MechKiM), we simulated blood‐referenced CLr (CLr,b) for 30,000 virtual drugs (neutral, monoanionic ...
Toshiaki Tsuchitani +2 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2015 Background/Aims: Hyperuricemia is an independent risk factor for chronic kidney disease and cardiovascular disease. Here, we examined the combined protective effects of Chinese herbal formula Si-Wu-Tang and Er-Miao-San on hyperuricemia and renal ...
Yongping Guo +3 more
doaj +1 more source
PHENOTYPIC BIOMARKERS FOR ASSESSING INTERINDIVIDUAL VARIABILITY IN RENAL DRUG SECRETION BY ORGANIC ANION TRANSPORTERS (OAT1 AND OAT3) [PDF]
Renal organic anion transporter 1 (OAT1) and OAT3 are involved in the basolateral uptake of various drugs (e.g., furosemide, penicillin, and methotrexate) and endogenous metabolites (e.g., pyridoxic acid, taurine, steroids, and bile acids ...
Thakur, Aarzoo
core +1 more source
Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science
Clinical and Translational Science, Volume 19, Issue 9, September 2026.ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley +1 more source
针刺研究, 2019 Objective To observe the effect of acupuncture at"Shenshu"(BL23)-"Taixi"(KI3)on the levels of serum uric acid(SUA)and expression of renal urate-anion transporter 1(URAT1)and organic anion transporter 1(OAT1)proteins in hyperuricemia(HUA)rats,so as to ...
LIU Xu-feng +6 more
doaj +2 more sources
Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney: A Phylogenetic, Ontogenetic and Cell Dynamic Perspective [PDF]
, 2022 Over the course of more than 500 million years, the kidneys have undergone a remarkable evolution from primitive nephric tubes to intricate filtration-reabsorption systems that maintain homeostasis and remove metabolic end products from the body.
Jansen, Katja +12 more
core
Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
Clinical Pharmacology of Eplontersen, the First Approved GalNAc‐Conjugated Antisense Oligonucleotide
The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.Abstract Eplontersen is a GalNAc‐conjugated antisense oligonucleotide (ASO) approved for the treatment of hereditary transthyretin‐mediated amyloidosis with polyneuropathy (ATTRv‐PN). GalNAc conjugation enables targeted hepatic delivery and improved potency compared with unconjugated ASOs.
Rosie Z. Yu +4 more
wiley +1 more source