Results 91 to 100 of about 5,743 (215)
Scientific Reports, 2017 In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two “drug” transporters of the organic anion transporter (OAT) family:
Wei Wu, Kevin T. Bush, Sanjay K. Nigam
doaj +1 more source
Cellular Physiology and Biochemistry, 2015 Background/Aims: Hyperuricemia is an independent risk factor for chronic kidney disease and cardiovascular disease. Here, we examined the combined protective effects of Chinese herbal formula Si-Wu-Tang and Er-Miao-San on hyperuricemia and renal ...
Yongping Guo +3 more
doaj +1 more source
Scientific Reports, 2021 Indoxyl sulfate (IS) accumulates in the body in chronic kidney disease (CKD). In the renal proximal tubules, IS excretion is mediated by OAT1/3 and ABCG2. These transporters are inhibited by some hypouricemic agents; OATs by probenecid and benzbromarone,
Tetsuya Taniguchi +7 more
doaj +1 more source
Activation of Protein Kinase Cζ Increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated Transport [PDF]
Journal of Biological Chemistry, 2009 Organic anion transporters (OATs) play a pivotal role in the clearance of small organic anions by the kidney, yet little is known about how their activity is regulated. A yeast two-hybrid assay was used to identify putative OAT3-associated proteins in the kidney. Atypical protein kinase Czeta (PKCzeta) was shown to bind to OAT3.
Barros, Scott +6 more
openaire +3 more sources
Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney +3 more
wiley +1 more source
Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes
PharmaceuticalsBackground/Objectives: Pinocembrin is a promising drug candidate for treating ischemic stroke. The interaction of pinocembrin with drug transporters and drug-metabolizing enzymes is not fully revealed.
Sirima Sangkapat +6 more
doaj +1 more source
Specific interactions leading to transgressive overyielding in cover crop mixtures [PDF]
, 2017 Growing mixtures of species instead of sole crops is expected to increase the ecosystem services provided by cover crops. This study aimed at understanding the interactions between species and investigating how they affect the performance of the mixture.
Amossé, Camille +5 more
core +2 more sources
Establishment of a novel cynomolgus monkey model of hyperuricemia
Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 354-366, February 2026.We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang +12 more
wiley +1 more source
A consensus statement on the renal monitoring of Australian patients receiving tenofovir based antiviral therapy for HIV/HBV infection [PDF]
, 2014 A number of antiviral agents used against Human Immunodeficiency Virus (HIV) infection and hepatitis B virus (HBV) mono or co-infection have been associated with real nephrotoxicity (including tenofovir disoproxil fumarate (TDF), atazanavir, indinavir ...
Abbas, R. +9 more
core +3 more sources
Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. [PDF]
, 2000 Potassium leak conductances were recently revealed to exist as independent molecular entities. Here, the genomic structure, cardiac localization, and biophysical properties of a murine example are considered.
Buck, ME +4 more
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