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Organic Anion Transporter Family: Current Knowledge
Journal of Pharmacological Sciences, 2006 .: Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in ...
Naohiko Anzai +2 more
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The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers [PDF]
Frontiers in Pharmacology, 2017 Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Tea Lanišnik Rižner +2 more
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Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions [PDF]
Journal of Xenobiotics, 2023 Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing the
Aaron O. Buaben, Ryan M. Pelis
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Drug Design, Development and Therapy, 2015 Hyeon-Uk Jeong,1 Mihwa Kwon,2 Yongnam Lee,3 Ji Seok Yoo,3 Dae Hee Shin,3 Im-Sook Song,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences ...
Jeong HU +6 more
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Journal of Pharmacological Sciences, 2004 Human organic anion transporter OAT4 is expressed in the kidney and placenta and mediates high-affinity transport of estrone-3-sulfate (E1S). Because a previous study demonstrated no trans-stimulatory effects by E1S, the mode of organic anion transport ...
Sophapun Ekaratanawong +8 more
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Molecular basis of prostaglandin E2 reuptake by organic anion transporter PGT [PDF]
Nature CommunicationsProstaglandins (PGs) are bioactive lipids that regulate inflammation, reproduction, and vasopermeability. Timely clearance of excessive PGs is critical to prevent potential damages caused by prolonged signalling.
Zhini Zhu +8 more
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The activity of organic anion transporter-3: Role of dexamethasone [PDF]
Journal of Pharmacological Sciences, 2018 Human organic anion transporter-3 (hOAT3) is richly expressed in the kidney, where it plays critical roles in the secretion, from the blood to urine, of clinically important drugs, such as anti-viral therapeutics, anti-cancer drugs, antibiotics ...
Haoxun Wang, Chenchang Liu, Guofeng You
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A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A
Journal of Pharmacological Sciences, 2011 .: In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system.
Promsuk Jutabha +6 more
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Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
Journal of Pharmacological Sciences, 2008 Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa +9 more
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Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3− Exchange [PDF]
Journal of Biological Chemistry, 1997 Organic anion transporting polypeptide (oatp) is an integral membrane protein cloned from rat liver that mediates Na+-independent transport of organic anions such as sulfobromophthalein and taurocholic acid. Previous studies in rat hepatocytes suggested that organic anion uptake is associated with base exchange.
L M, Satlin, V, Amin, A W, Wolkoff
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