Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions [PDF]
Journal of Xenobiotics, 2023 Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing the
Aaron O. Buaben, Ryan M. Pelis
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Phosphorylation dynamics of sodium-independent organic anion transporter SLCO4A1 and its role in diseases: a review [PDF]
Frontiers in Systems BiologySLCO4A1, a membrane-localized organic anion transporter belonging to the solute carrier (SLC) family, mediates the sodium-independent transport of endogenous substrates, including steroid hormones, prostaglandins, and thyroid hormones. Despite increasing
Jaytha Thomas +6 more
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Molecular basis of prostaglandin E2 reuptake by organic anion transporter PGT [PDF]
Nature CommunicationsProstaglandins (PGs) are bioactive lipids that regulate inflammation, reproduction, and vasopermeability. Timely clearance of excessive PGs is critical to prevent potential damages caused by prolonged signalling.
Zhini Zhu +8 more
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The activity of organic anion transporter-3: Role of dexamethasone [PDF]
Journal of Pharmacological Sciences, 2018 Human organic anion transporter-3 (hOAT3) is richly expressed in the kidney, where it plays critical roles in the secretion, from the blood to urine, of clinically important drugs, such as anti-viral therapeutics, anti-cancer drugs, antibiotics ...
Haoxun Wang, Chenchang Liu, Guofeng You
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The interaction of flavonoids, alkaloids, and terpenoids with the major drug transporters in the organic anion transporting polypeptide and organic anion transporter families [PDF]
Acta Pharmaceutica Sinica BNatural compounds are ubiquitously found in the plant kingdom and are well-known for their beneficial effects on human health. The easy accessibility and the relatively affordable price make them popular choices for self-medication and/or as part of a ...
Zichong Li +3 more
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Structural characterization of the human organic anion transporter OATP2B1 [PDF]
Cell DiscoveryJiahui Chen +10 more
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Molecules, 2022 The aim of this study is to evaluate the anti-hyperuricemia effect and clarify the possible mechanisms of flavonoids and phenolics of MOL (MOL-FP) in mice.
Xiaowei Luo +14 more
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Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. [PDF]
PLoS ONE, 2017 Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of
Lisa Chedik +7 more
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Interactions of organophosphate flame retardants with human drug transporters
Ecotoxicology and Environmental Safety, 2023 Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible
Valentin Tastet +6 more
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Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance
Pharmaceutics, 2020 The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
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