Results 1 to 10 of about 25,055 (157)

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Drug Design, Development and Therapy, 2015
Hyeon-Uk Jeong,1 Mihwa Kwon,2 Yongnam Lee,3 Ji Seok Yoo,3 Dae Hee Shin,3 Im-Sook Song,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences ...
Jeong HU, Kwon M, Lee Y, Yoo JS, Shin DH, Song IS, Lee HS   +6 more
doaj   +6 more sources

Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions [PDF]

Journal of Xenobiotics, 2023
Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing the
Aaron O. Buaben, Ryan M. Pelis
doaj   +2 more sources

Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver. [PDF]

World J Clin Cases, 2019
Organic anion transporters (OATs) and organic anion transporter polypeptides (OATPs) are classified within two SLC superfamilies, namely, the SLC22A superfamily and the SLCO superfamily (formerly the SLC21A family), respectively. They are expressed in many tissues, such as the liver and kidney, and mediate the absorption and excretion of many ...
Li TT, An JX, Xu JY, Tuo BG.
europepmc   +3 more sources

Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins

Journal of Pharmacological Sciences, 2008
Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa, Michio Takeda, Suparat Khamdang, Rie Noshiro-Kofuji, Minoru Tsuda, Surawat Jariyawat, Toshiyuki Fukutomi, Samaisukh Sophasan, Naohiko Anzai, Hitoshi Endou   +9 more
doaj   +4 more sources

Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules

Journal of Pharmacological Sciences, 2004
Human organic anion transporter OAT4 is expressed in the kidney and placenta and mediates high-affinity transport of estrone-3-sulfate (E1S). Because a previous study demonstrated no trans-stimulatory effects by E1S, the mode of organic anion transport ...
Sophapun Ekaratanawong, Naohiko Anzai, Promsuk Jutabha, Hiroki Miyazaki, Rie Noshiro, Michio Takeda, Yoshikatsu Kanai, Samaisukh Sophasan, Hitoshi Endou   +8 more
doaj   +3 more sources

Molecular basis of prostaglandin E2 reuptake by organic anion transporter PGT [PDF]

Nature Communications
Prostaglandins (PGs) are bioactive lipids that regulate inflammation, reproduction, and vasopermeability. Timely clearance of excessive PGs is critical to prevent potential damages caused by prolonged signalling.
Zhini Zhu, Yaohui Li, Hao Xia, Chuanhui Yang, Zixuan Zhou, Yulin Chao, Qian Ba, Dianfan Li, Qianhui Qu   +8 more
doaj   +2 more sources

The activity of organic anion transporter-3: Role of dexamethasone [PDF]

Journal of Pharmacological Sciences, 2018
Human organic anion transporter-3 (hOAT3) is richly expressed in the kidney, where it plays critical roles in the secretion, from the blood to urine, of clinically important drugs, such as anti-viral therapeutics, anti-cancer drugs, antibiotics ...
Haoxun Wang, Chenchang Liu, Guofeng You
doaj   +2 more sources

A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A

Journal of Pharmacological Sciences, 2011
.: In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system.
Promsuk Jutabha, Naohiko Anzai, Keitaro Hayashi, Mariko Domae, Kohsuke Uchida, Hitoshi Endou, Hiroyuki Sakurai   +6 more
doaj   +3 more sources

The Organic Anion Transporter (OATP) Family

Drug Metabolism and Pharmacokinetics, 2004
In the last decade, many organic anion transporters have been isolated, characterized their distribution and substrates. The recently identified organic anion transporter family OATP (organic anion transporting polypeptide)/LST (liver-specific transporter) family, transport bile acids, hormones as well as eicosanoids, various compounds (BSP, HMG-CoA ...
Tsuyoshi Mikkaichi, Takehiro Suzuki, Masayuki Tanemoto   +2 more
exaly   +3 more sources

Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function [PDF]

American Journal of Physiology - Renal Physiology, 2015
Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare selected transport properties. Common to OAT1, OAT2, and OAT3 is their ability to transport cGMP. OAT2 interacted with
Yohannes Hagos, Wolfgang Krick, Gerhard Burckhardt   +2 more
exaly   +4 more sources