Results 41 to 50 of about 26,243 (291)

The superfamily of organic anion transporting polypeptides

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2003
Organic anion transporting polypeptides (Oatps/OATPs) form a growing gene superfamily and mediate transport of a wide spectrum of amphipathic organic solutes. Different Oatps/OATPs have partially overlapping and partially distinct substrate preferences for organic solutes such as bile salts, steroid conjugates, thyroid hormones, anionic oligopeptides ...
Hagenbuch, B., Meier, P. J.
openaire   +2 more sources

Inhibition of the Hepatic Uptake of ^99mTc-Tetrofosmin Using an Organic Cation Transporter Blocker

Pharmaceutics, 2021
The accumulation of high levels of 99mTc-tetrofosmin (99mTc-TF) in the hepatobiliary system can lead to imaging artifacts and interference with diagnosis.
Kodai Nishi, Masato Kobayashi, Minori Kikuchi, Asuka Mizutani, Yuka Muranaka, Ikumi Tamai, Keiichi Kawai, Takashi Kudo   +7 more
doaj   +1 more source

Functional expression of pig renal organic anion transporter 3 (pOAT3)

, 2005
With the cloning of pig renal organic anion transporter 1 (pOAT1) (Biochimie 84 (2002) 1219) we set up a model system for comparative studies of cloned and natively isolated membrane located transport proteins.
Burckhardt, Gerhard, Bahn, A., Hagos, Yohannes, Braun, I. M., Krick, W.   +4 more
core   +1 more source

Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

Journal of Pharmacological Sciences, 2004
We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1
Suparat Khamdang, Michio Takeda, Minoru Shimoda, Rie Noshiro, Shinichi Narikawa, Xiu-Lin Huang, Atsushi Enomoto, Pawinee Piyachaturawat, Hitoshi Endou   +8 more
doaj   +1 more source

Cloning of the pig renal organic anion transporter 1 (pOAT1)

, 2002
A pig kidney cDNA library was screened for the porcine ortholog of the multispecific organic anion transporter 1 (pOAT1). Several positive clones were isolated resulting in two alternatively spliced cDNA clones of pOAT1 (pOAT1 and pOAT1A).
Burckhardt, Gerhard, Bahn, A., Sendler, M., Hagos, Yohannes, Asif, Abdul Rahman, Krick, W.   +5 more
core   +1 more source

Choroid plexus transport: gene deletion studies

Fluids and Barriers of the CNS, 2011
This review examines the use of transporter knockout (KO) animals to evaluate transporter function at the choroid plexus (the blood-CSF barrier; BCSFB). Compared to the blood-brain barrier, there have been few such studies on choroid plexus (CP) function.
Keep Richard F, Smith David E
doaj   +1 more source

Effects of organic anion transporter inhibitors on MA cytotoxicity.

, 2015
The organic anion transporter inhibitor probenecid (P) blocked MA-induced LDH release, whereas succinic acid, p-aminohippuric acid (PAH) and taurocholic acid were ineffective.
Ali Tunç Tuncel (757088), Bei-Tzu Wang (757090), Jürgen Günther Okun (757091), Marina Alexandra Morath (757093), Sven Wolfgang Sauer (757094), Thorsten Ruppert (757089), Stefan Kölker (757092)   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta [PDF]

, 2002
Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates.
Stallmach, T., Hagenbuch, B., Ugele, B., Meier, P. J., St-Pierre, M. V.   +4 more
core   +1 more source

Human Organic Anion Transporters Mediate the Transport of Tetracycline

Japanese Journal of Pharmacology, 2002
The purpose of this study was to elucidate the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs. The cells stably expressing hOAT1, hOAT2, hOAT3 and hOAT4 exhibited a higher amount of [3H]tetracycline uptake compared with mock cells.
Babu, Ellappan, Takeda, Michio, Narikawa, Shinichi, Kobayashi, Yasuna, Yamamoto, Toshinori, Cha, Seok Ho, Sekine, Takashi, Sakthisekaran, Dhanapal, Endou, Hitoshi   +8 more
openaire   +3 more sources