Results 61 to 70 of about 26,243 (291)

Acetylation turns leucine into a drug by membrane transporter switching

Scientific Reports, 2021
Small changes to molecules can have profound effects on their pharmacological activity as exemplified by the addition of the two-carbon acetyl group to make drugs more effective by enhancing their pharmacokinetic or pharmacodynamic properties. N-acetyl-d,
Grant C. Churchill, Michael Strupp, Cailley Factor, Tatiana Bremova-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt, Antony Galione   +7 more
doaj   +1 more source

Evaluation for Potential Drug–Drug Interaction of MT921 Using In Vitro Studies and Physiologically–Based Pharmacokinetic Models

Pharmaceuticals, 2021
MT921 is a new injectable drug developed by Medytox Inc. to reduce submental fat. Cholic acid is the active pharmaceutical ingredient, a primary bile acid biosynthesized from cholesterol, endogenously produced by liver in humans and other mammals ...
Hyo-jeong Ryu, Hyun-ki Moon, Junho Lee, Gi-hyeok Yang, Sung-yoon Yang, Hwi-yeol Yun, Jung-woo Chae, Won-ho Kang   +7 more
doaj   +1 more source

Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury

, 2004
Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury.BackgroundThe epithelial cells lining the renal proximal tubule have been shown to be the primary cellular targets where mercuric ions gain entry ...
Zalups, Rudolfs K., Aslamkhan, Amy G., Ahmad, Sarfaraz   +2 more
core   +1 more source

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc3-Conjugated 2′-MOE-ASOs

Molecular Therapy: Nucleic Acids, 2017
Antisense oligonucleotides are metabolized by nucleases and drug interactions with small drug molecules at either the cytochrome P450 (CYP) enzyme or transporter levels have not been observed to date.
Colby S. Shemesh, Rosie Z. Yu, Mark S. Warren, Michael Liu, Mirza Jahic, Brandon Nichols, Noah Post, Song Lin, Daniel A. Norris, Eunju Hurh, Jane Huang, Tanya Watanabe, Scott P. Henry, Yanfeng Wang   +13 more
doaj   +1 more source

Genistein ameliorates hyperuricemia-associated nephropathy in hyperuricemic mice

Food and Agricultural Immunology, 2021
Hyperuricemia is a metabolic disease caused by excessive production of uric acid (UA), which can cause gout, hypertension, hyperlipidemia and other diseases.
Bi Wei-Yun, Zhu Cailin
doaj   +1 more source

Role of Glycosylation in the Organic Anion Transporter OAT1 [PDF]

Journal of Biological Chemistry, 2004
Organic anion transporters (OAT) play essential roles in the body disposition of clinically important anionic drugs, including antiviral drugs, antitumor drugs, antibiotics, antihypertensives, and anti-inflammatories. We reported previously (Kuze, K., Graves, P., Leahy, A., Wilson, P., Stuhlmann, H., and You, G. (1999) J. Biol. Chem.
Kunihiko, Tanaka, Wen, Xu, Fanfan, Zhou, Guofeng, You   +3 more
openaire   +2 more sources

From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics

Advanced Functional Materials, EarlyView.
We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou, Bokeon Kwak, Dario Floreano, Esther Amstad   +3 more
wiley   +1 more source

Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney

, 1998
The functional characteristics of rat organic anion transporter OAT1 were investigated using Xenopus laevis oocytes. Uptake of p-aminohippurate (PAH) by the oocytes expressing OAT1 was markedly inhibited by glutarate, α-ketoglutarate and probenecid ...
Kenji Takami, Ken-ichi Inui, Takami, Kenji, Inui, Ken-ichi, Yukiya Hashimoto, Uwai, Yuichi, Okuda, Masahiro, Yuichi Uwai, Masahiro Okuda, Hashimoto, Yukiya   +9 more
core   +1 more source

In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters

Molecules, 2019
APINACA (known as AKB48, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide), an indazole carboxamide synthetic cannabinoid, has been used worldwide as a new psychoactive substance.
Sunjoo Kim, Won-Gu Choi, Mihwa Kwon, Sowon Lee, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Im-Sook Song, Hye Suk Lee   +8 more
doaj   +1 more source

Molecular pharmacology of renal organic anion transporters [PDF]

American Journal of Physiology-Renal Physiology, 2000
Renal organic anion transport systems play an important role in the elimination of drugs, toxic compounds, and their metabolites, many of which are potentially harmful to the body. The renal proximal tubule is the primary site of carrier-mediated transport from blood to urine of a wide variety of anionic substrates.
Aubel, R.A.M.H. van, Masereeuw, R., Russel, F.G.M.   +2 more
openaire   +3 more sources