Results 81 to 90 of about 52,147 (304)

Interactions of 172 plant extracts with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8): a study on herb-drug interactions [PDF]

PeerJ, 2017
Background Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the ...
Hang Lu, Zhiqiang Lu, Xue Li, Gentao Li, Yilin Qiao, Robert P. Borris, Youcai Zhang   +6 more
doaj   +2 more sources

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs [PDF]

, 2009
Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives ...
Sarah Shugarts, Leslie Z. Benet, RL Juliano, MF Fromm, CP Landowski, N Mizuno, CY Wu, GL Amidon, C Srimaroeng, ZM Zaïr, G Ciarimboli, B Hagenbuch, Y Toyoda, SF Zhou, H Kusuhara, S Choudhuri, BL Urquhart, AD Mottino, LW Chinn, K Maeda, T Nakamura, JE Montfoort van, M Okabe, L Li, LM Satlin, C Mahagita, A Kosters, T Takagi, NA Kasim, Y Yang, LZ Benet, H Lennernäs, N Li, M Katoh, X Cao, R Hayeshi, JM Arthur, D Sun, ML Chen, Y Shirasaka, U Fagerholm, CY Wu, X Cao, CL Cummins, CL Cummins, UI Schwarz, K Westphal, JS Lee, AL Sesink, Y Su, H Glaeser, Y Koitabashi, A Dahan, B Greiner, JM Custodio, RG Tirona, Y Su, T Watanabe, YY Lau, HX Zheng, JW Deng, Y Shu, X Tian, N Zelcer, RB Parker, LZ Benet, GA Kullak-Ublick, C Solas, S Zhou, SX Peng, C Tannergren, S Sahin, Y Kato, C Luna- Tortós, K Engel, M Zhou, BL Urquhart, MO Magnusson, N Ishiguro, Q Wang, DG Bailey, SR Vavricka, U Muenster, K Takenaka, DA Volpe, C Hilgendorf, M Lohitnavy, T Lavé, SS Buck De, Z Wang, N Parrott, A Bonen, M Grube, W Lee, MJ Bijvelds, JH Gray, RP Owen, A Bodo, Q Tian, L Ci, RD Huber, B Gao, G Jedlitschky, M Farias, SY Yao, D Kirat, D Meredith, I Knutter, DA Groneberg, M Hayer-Zillgen, S Sakamoto, H Li, JY Li, H Yabuuchi, I Elimrani, ILMH Aye, JD Allen, O Janneh, K Fujiwara, H Potschka, E Pollex, F Boraldi, W Lin, KR Robillard, AJ Smith, M Hirano, E Jigorel, EM Leslie, RB Kim, S Khamdung, S Halwachs, A Geick, O Burk, HR Kast, J Staudinger, M Assem, I Szatmari, M Ananthanarayanan, JJ Eloranta, Y Miki, JM Maglich, D Jung, Y Morita, S Hoffmeyer, Y Kurata, SY Yi, FA Jong de, A Sparreboom, A Sparreboom, W Zhang, Y Nishizato, J Mwinyi, M Niemi, M Niemi, I Ieiri, MK Pasanen, W Zhang, DA Katz, X Xiang, S Oswald, SV Vormfelde, M Miura   +161 more
core   +3 more sources

Short-term regulation of organic anion transporters [PDF]

Pharmacology & Therapeutics, 2010
Organic anion transporters (OATs), which belong to the superfamily SLC22A, are key determinants in the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, and, therefore, are critical for the survival of mammalian species.
Peng, Duan, Guofeng, You
openaire   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Auto‐Generated Valence States in Electrocatalysts for Boosting Oxygen and Hydrogen Evolution Kinetics in Alkaline Water/Alkaline Seawater/Simulated Seawater/Natural Seawater

Advanced Functional Materials, EarlyView.
This review systematically highlights the latest achievements in mixed‐valence states relevant to hydrogen and oxygen evolution reactions, providing essential insights into future directions and methods for large‐scale practical implementation. This critical review is expected to provide an overview of recent advancements in diverse valence‐state metal
Jitendra N. Tiwari, Gokul Bhaskaran, Krishan Kumar, Yun Suk Huh, Young‐Kyu Han   +4 more
wiley   +1 more source

Tuning the electronic, photophysical and charge transfer properties of small D-A molecules based on Thienopyrazine-terthienyls by changing the donor fragment: A DFT study [PDF]

, 2017
Indexación: Scopus.Four acceptor-donor organic conjugated molecules based on thieno[3,4-b]pyrazine-terthienyls were analyzed in order to explore the effect of the donor substituent on their molecular structures, electronic and optical properties. Density
Aicha, Y.A., Bouachrine, M., Bouzzine, S.M., Hamidi, M., Mendoza-Huizar, L.H., Salgado-Morán, G., Tagle, R.R., Zair, T.   +7 more
core   +1 more source

Zwitterionic Self‐Assembled Monolayer for Simultaneous Noise Suppression and Hole Extraction in High‐Performance Near‐Infrared Organic Photodetectors

Advanced Functional Materials, EarlyView.
This study presents a new hole transporting material (HTM) mechanism for self‐assembled monolayers in near‐infrared organic photodetectors. The formation of zwitterions induces a strong electric field that significantly increases the work function of HTM‐coated indium tin oxide substrates. The devices exhibit low dark current and noise, along with high
Jiyoung Shin, Gyeong Min Lee, Juyeon Shin, Jaewoong Kim, Tae Hyuk Kim, Do Yeon Kim, Myeong In Kim, Kyeounghak Kim, Jae Won Shim, In Hwan Jung   +9 more
wiley   +1 more source

Covalent Organic Frameworks for Photocatalytic CO2 Reduction: Metal Integration Principles, Strategies and Functions

Advanced Functional Materials, EarlyView.
Covalent organic frameworks (COFs) with metals have been recognized as versatile platforms for photocatalytic CO2 reduction (CO2PRR). Herein, an overview of metal integration strategies for COFs is systematically summarized. Regulatory mechanisms and structure–activity relationships between metal integration and COF‐based CO2PRR are emphasized.
Jie He, Minxian Zhang, Jinqiang Zhang, Hongqi Sun, Shaobin Wang, Xiaoguang Duan   +5 more
wiley   +1 more source

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics [PDF]

, 2015
Membrane transporters play an essential role in the transport of endogenous and exogenous compounds, and consequently they mediate the uptake, distribution, and excretion of many drugs. The clinical relevance of transporters in drug disposition and their
Knibbe, C.A.J. (Catherijne), Mooij, M.G. (Miriam), Nies, A.T. (Anne T.), Schaeffeler, E. (Elke), Schwab, M. (Matthias), Tibboel, D. (Dick), Wildt, S.N. (Saskia) de   +6 more
core   +5 more sources

From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics

Advanced Functional Materials, EarlyView.
We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou, Bokeon Kwak, Dario Floreano, Esther Amstad   +3 more
wiley   +1 more source