Results 1 to 10 of about 2,100,066 (288)
Renal drug transporters and their significance in drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
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Research progress on reversing tumor resistance based on the epigenetics of drug metabolizing enzymes and transporters [PDF]
Yixue xinzhi zazhi, 2020 The molecular mechanisms related to drug metabolism of tumor resistance include drug inactivation, increase of drug efflux, and decrease of drug uptake, The epigenetic regulation mechanism of drug metabolizing enzymes and drug transporters, such as DNA ...
Xiao-Li ZHENG +3 more
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An update on placental drug transport and its relevance to fetal drug exposure
Medical Review, 2022 Pregnant women are often complicated with diseases that require treatment with medication. Most drugs administered to pregnant women are off-label without the necessary dose, efficacy, and safety information. Knowledge concerning drug transfer across the
Mao Qingcheng, Chen Xin
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Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery
Pharmaceutics, 2022 Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration.
Rong Lu +4 more
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Role for Drug Transporters in Chemotherapy‐Induced Peripheral Neuropathy
Clinical and Translational Science, 2021 Chemotherapy‐induced peripheral neuropathy (CIPN) is a common and dose‐limiting toxicity to widely used chemotherapeutics. Although the exact molecular mechanism of chemotherapy‐induced peripheral neuropathy remains elusive, there is consensus that it is
Tore B. Stage +3 more
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ADMET and DMPK, 2017 It is clear that many drug transporters (both ABCs and SLCs) are present in the human skin. Different in vitro skin models can be used to investigate the role of drug transporters in the skin despite quantitative differences in expression profile across ...
Hanan Osman-Ponchet +3 more
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Advances in Pharmacokinetic Mechanisms of Transporter-Mediated Herb-Drug Interactions
Pharmaceuticals, 2022 As the use of herbs has become more popular worldwide, there are increasing reports of herb-drug interactions (HDIs) following the combination of herbs and drugs. The active components of herbs are complex and have a variety of pharmacological activities,
Jie Li +4 more
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Utilizing in vitro transporter data in IVIVE-PBPK: an overview
ADMET and DMPK, 2017 In vitro-in vivo extrapolation (IVIVE) integrated in physiologically-based pharmacokinetic (PBPK) models have been increasingly used during drug discovery and development processes to predict human pharmacokinetic (PK) parameters.
Pankajini Mallick
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Journal of Advanced Biotechnology and Experimental Therapeutics, 2018 Drug-drug interactions is one of the major determinant in drug development and clinical applications. Individual differences in pharmacokinetics may cause extensive variability in drug efficacy, toxicity and adverse drug reactions, and represent a major ...
Md Masud Parvez +2 more
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A phosphotyrosine switch regulates organic cation transporters
Nature Communications, 2016 Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug ...
Jason A. Sprowl +23 more
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