Machine Learning Techniques Applied to the Study of Drug Transporters [PDF]
Molecules, 2023 With the advancement of computer technology, machine learning-based artificial intelligence technology has been increasingly integrated and applied in the fields of medicine, biology, and pharmacy, thereby facilitating their development.
Xiaorui Kong +8 more
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Renal drug transporters and their significance in drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
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Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition
Pharmaceutics, 2023 Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the brain, facilitating their entry into the central nervous system (CNS).
Md Masud Parvez +4 more
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Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease [PDF]
PharmaceuticsDrug transporters are crucial for facilitating the distribution and elimination of drugs from the body, yet their broader physiological functions remain underexplored.
Christine Blaze, Yan Shu
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Contribution and expression of renal drug transporters in renal cell carcinoma [PDF]
Frontiers in PharmacologyRenal cell carcinoma (RCC) is a common substantive tumor. According to incomplete statistics, RCC incidence accounts for approximately 90% of renal malignant tumors, and is the second most prevalent major malignant tumor in the genitourinary system ...
Yawen Zuo +7 more
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Expanding the Gene Expression Profiling of Drug Transporters and Drug-Metabolizing Enzymes to Include the Upper Female Reproductive Tract [PDF]
PharmaceuticsBackground/Objectives: With the ongoing efforts in supporting the discovery of novel targeted drug delivery systems for the upper region of the female reproductive tract (FRT), it is imperative to understand the local drug disposition pathways. We aim to
An Le +6 more
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Glutamine transporters as pharmacological targets: From function to drug design
Asian Journal of Pharmaceutical Sciences, 2020 Among the different targets of administered drugs, there are membrane transporters that play also a role in drug delivery and disposition. Moreover, drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity ...
Mariafrancesca Scalise +4 more
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Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome [PDF]
Frontiers in NeuroscienceBackgroundNeonatal Opioid Withdrawal Syndrome (NOWS) is a consequence of in-utero exposure to prenatal maternal opioids, resulting in the manifestation of symptoms like irritability, feeding problems, tremors, and withdrawal signs.
Uppala Radhakrishna +8 more
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Editorial: Diverse functions of drug transporters [PDF]
Frontiers in PharmacologyJeffry C. Granados +2 more
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Overview of Drug Transporters in Human Placenta [PDF]
International Journal of Molecular Sciences, 2021 Michiko Yamashita +2 more
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