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Renal drug transporters and their significance in drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
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Extracellular Vesicles as Drug Transporters. [PDF]
Int J Mol Sci, 2023 Extracellular vesicles (EVs) are lipid bilayer-delimited particles. According to their size and synthesis pathway, EVs can be classified into exosomes, ectosomes (microvesicles), and apoptotic bodies.
Nowak M +4 more
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Frontiers in Pharmacology, 2021 The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process.
Wei Zou +9 more
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Transcriptional Regulation of Solute Carrier (SLC) Drug Transporters. [PDF]
Drug Metab Dispos, 2022 Facilitated transport is necessitated for large size, charged, and/or hydrophilic drugs to move across the membrane. The drug transporters in the solute carrier (SLC) superfamily, mainly including organic anion-transporting polypeptides, organic anion ...
Zhou S, Shu Y.
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Machine Learning Techniques Applied to the Study of Drug Transporters [PDF]
Molecules, 2023 With the advancement of computer technology, machine learning-based artificial intelligence technology has been increasingly integrated and applied in the fields of medicine, biology, and pharmacy, thereby facilitating their development.
Xiaorui Kong +8 more
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Overview of Drug Transporters in Human Placenta. [PDF]
Int J Mol Sci, 2021 The transport of drugs across the placenta is a point of great importance in pharmacotherapy during pregnancy. However, the knowledge of drug transport in pregnancy is mostly based on experimental clinical data, and the underlying biological mechanisms ...
Yamashita M, Markert UR.
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Role for Drug Transporters in Chemotherapy‐Induced Peripheral Neuropathy
Clinical and Translational Science, 2021 Chemotherapy‐induced peripheral neuropathy (CIPN) is a common and dose‐limiting toxicity to widely used chemotherapeutics. Although the exact molecular mechanism of chemotherapy‐induced peripheral neuropathy remains elusive, there is consensus that it is
Tore B. Stage +3 more
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Contribution and expression of renal drug transporters in renal cell carcinoma [PDF]
Frontiers in PharmacologyRenal cell carcinoma (RCC) is a common substantive tumor. According to incomplete statistics, RCC incidence accounts for approximately 90% of renal malignant tumors, and is the second most prevalent major malignant tumor in the genitourinary system ...
Yawen Zuo +7 more
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Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease [PDF]
PharmaceuticsDrug transporters are crucial for facilitating the distribution and elimination of drugs from the body, yet their broader physiological functions remain underexplored.
Christine Blaze, Yan Shu
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Enantioselective Drug Recognition by Drug Transporters
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
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