Enantioselective Drug Recognition by Drug Transporters [PDF]
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
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Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia [PDF]
Frontiers in Pharmacology, 2022 Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia–gut microbiota–CYP450/drug transporter axis is emerging as a vital factor in drug metabolism.
Xue Bai +9 more
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A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy [PDF]
Pharmaceutics, 2023 The purpose of this literature review is to comprehensively summarize changes in the expression of phase II drug-metabolizing enzymes and drug transporters in both the pregnant woman and the placenta.
Christine Gong +3 more
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Emerging transporter-targeted nanoparticulate drug delivery systems
Acta Pharmaceutica Sinica B, 2019 Transporter-targeted nanoparticulate drug delivery systems (nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments ...
Hongyan Su +6 more
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Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood–Brain Barrier in vivo and in vitro [PDF]
Frontiers in Physiology, 2020 Ischemia/reperfusion injury is a major cause of acute kidney injury (AKI). AKI is characterized by a sudden decrease in kidney function, systemic inflammation, oxidative stress, and dysregulation of the sodium, potassium, and water channels.
Malgorzata Burek +7 more
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Drug transporter mRNA expression and genital inflammation in South African women on oral pre-exposure prophylaxis (PrEP) [PDF]
AIDS Research and TherapyGlobally HIV remains a major public health problem. In sub-Saharan Africa most new HIV infections occur in adolescent girls and young women. Previously tested antiretroviral drugs as different pre-exposure prophylaxis (PrEP) formulations have shown ...
Nomusa M. Zondo +9 more
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Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance [PDF]
Pharmaceutics, 2020 The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
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Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs
Pharmaceutics, 2011 Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs.
Jörg König +2 more
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Research and development of drug delivery systems based on drug transporter and nano-formulation [PDF]
Asian Journal of Pharmaceutical Sciences, 2020 Yi Peng, Sheng Ye, Yu Kang
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Pharmacology Research & Perspectives, 2023 Previous use of a mechanistic static model to accurately quantify the increased rosuvastatin exposure due to drug–drug interaction (DDI) with coadministered atazanavir underpredicted the magnitude of area under the plasma concentration–time curve ratio ...
Robert Elsby +5 more
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