Transporter-Mediated Drug Delivery
Molecules, 2023 Transmembrane transport of small organic and inorganic molecules is one of the cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier (SLC) proteins form the largest, albeit very diverse, superfamily with over 400 members ...
Gergely Gyimesi, Matthias A. Hediger
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Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia [PDF]
Frontiers in Pharmacology, 2022 Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia–gut microbiota–CYP450/drug transporter axis is emerging as a vital factor in drug metabolism.
Xue Bai +9 more
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A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy [PDF]
Pharmaceutics, 2023 The purpose of this literature review is to comprehensively summarize changes in the expression of phase II drug-metabolizing enzymes and drug transporters in both the pregnant woman and the placenta.
Christine Gong +3 more
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Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood–Brain Barrier in vivo and in vitro [PDF]
Frontiers in Physiology, 2020 Ischemia/reperfusion injury is a major cause of acute kidney injury (AKI). AKI is characterized by a sudden decrease in kidney function, systemic inflammation, oxidative stress, and dysregulation of the sodium, potassium, and water channels.
Malgorzata Burek +7 more
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Drug transporter mRNA expression and genital inflammation in South African women on oral pre-exposure prophylaxis (PrEP) [PDF]
AIDS Research and TherapyGlobally HIV remains a major public health problem. In sub-Saharan Africa most new HIV infections occur in adolescent girls and young women. Previously tested antiretroviral drugs as different pre-exposure prophylaxis (PrEP) formulations have shown ...
Nomusa M. Zondo +9 more
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Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance [PDF]
Pharmaceutics, 2020 The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
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Pharmacology Research & Perspectives, 2023 Previous use of a mechanistic static model to accurately quantify the increased rosuvastatin exposure due to drug–drug interaction (DDI) with coadministered atazanavir underpredicted the magnitude of area under the plasma concentration–time curve ratio ...
Robert Elsby +5 more
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Characteristics of novel polymer based on pseudo-polyamino acids GluLa-DPG-PEG600: binding of albumin, biocompatibility, biodistribution and potential crossing the blood-brain barrier in rats [PDF]
The Ukrainian Biochemical Journal, 2017 The aim of our work was to study biological properties of the polymer based on pseudo-polyamino acids GluLa-DPG-PEG600, its ability to bind albumin, as well as its localization in rat body and influence on physiological and functional state of rat ...
B. O. Chekh +5 more
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The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy
Pharmaceutics, 2023 Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play a crucial role in the cellular uptake of drugs.
Elena Puris, Gert Fricker, Mikko Gynther
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Cells, 2020 An abnormality in hedgehog (Hh) signaling has been implicated in the progression of prostate cancer (PCa) to a more aggressive and therapy-resistant disease.
Santosh Kumar Singh +5 more
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