Results 1 to 10 of about 2,255,889 (297)
Enantioselective Drug Recognition by Drug Transporters [PDF]
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
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Pharmacological Research, 2023 Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous compounds and drugs across membranes, thus playing a critical role in disease susceptibility and drug response.
Anne T. Nies +14 more
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Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
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Effects of Valproic Acid on Cerebral Nutrient Carriers' Expression in the Rat
Frontiers in Pharmacology, 2018 Objective: The antiepileptic drug valproate has been shown to affect the expression of carriers for essential compounds and drugs in extracerebral tissues.
Aniv Mann Brukner +4 more
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A Mini-Review of the Role of Glutamate Transporter in Drug Addiction
Frontiers in Neurology, 2019 Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs.
Wenjun Wang +3 more
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Equine Drug Transporters: A Mini-Review and Veterinary Perspective
Pharmaceutics, 2020 Xenobiotic transport proteins play an important role in determining drug disposition and pharmacokinetics. Our understanding of the role of these important proteins in humans and pre-clinical animal species has increased substantially over the past few ...
Brielle Rosa
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Molecular Therapy: Methods & Clinical Development, 2020 Because many peptide and peptide-mimetic drugs are substrates of peptide transporter 1, it is important to evaluate the peptide transporter 1-mediated intestinal absorption of drug candidates in the early phase of drug development.
Kanae Kawai +8 more
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Emerging transporter-targeted nanoparticulate drug delivery systems
Acta Pharmaceutica Sinica B, 2019 Transporter-targeted nanoparticulate drug delivery systems (nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments ...
Hongyan Su +6 more
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Pharmaceutics, 2020 The Caco-2 model is a well-accepted in vitro model for the estimation of fraction absorbed in human intestine. Due to the lack of cytochrome P450 3A4 (CYP3A4) activities, Caco-2 model is not suitable for the investigation of intestinal first-pass ...
Yunhai Cui +4 more
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mRNA levels of related Abcb genes change opposite to each other upon histone deacetylase inhibition in drug-resistant rat hepatoma cells. [PDF]
PLoS ONE, 2014 The multidrug-resistant phenotype of tumor cells is acquired via an increased capability of drug efflux by ABC transporters and causes serious problems in cancer treatment.
Adám Sike +6 more
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