Results 21 to 30 of about 251,779 (303)

Extracellular Vesicles as Drug Transporters

International Journal of Molecular Sciences, 2023
Extracellular vesicles (EVs) are lipid bilayer-delimited particles. According to their size and synthesis pathway, EVs can be classified into exosomes, ectosomes (microvesicles), and apoptotic bodies. Extracellular vesicles are of great interest to the scientific community due to their role in cell-to-cell communication and their drug-carrying ...
Monika Nowak, Julia Górczyńska, Katarzyna Kołodzińska, Jakub Rubin, Anna Choromańska   +4 more
openaire   +3 more sources

Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core   +1 more source

Effects of Valproic Acid on Cerebral Nutrient Carriers' Expression in the Rat

Frontiers in Pharmacology, 2018
Objective: The antiepileptic drug valproate has been shown to affect the expression of carriers for essential compounds and drugs in extracerebral tissues.
Aniv Mann Brukner, Tamir Ben-Hur, Asaf Honig, Dana Ekstein, Sara Eyal   +4 more
doaj   +1 more source

A Mini-Review of the Role of Glutamate Transporter in Drug Addiction

Frontiers in Neurology, 2019
Goals: The development of new treatment for drug abuse requires identification of targetable molecular mechanisms. The pathology of glutamate neurotransmission system in the brain reward circuit is related to the relapse of multiple drugs.
Wenjun Wang, Fancai Zeng, Yingying Hu, Xiang Li   +3 more
doaj   +1 more source

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal [PDF]

, 2009
Human African trypanosomiasis (HAT) manifests as a chronic infection caused by <i>Trypanosoma brucei gambiense</i>, or as a more acute form due to <i>T. b. rhodesiense</i>.
Barbara Nerima, Pascal Mäser, Nerima, B., Barrett, M.P., Nerima, Barbara, de Koning Harry P., Matovu, E., Kazibwe, Anne J., Anne J N Kazibwe, Kazibwe Anne J. N., Enock Matovu, Kazibwe, A.J.N., Mäser, Pascal, De Koning, H.P., Matovu Enock, Harry P de Koning, Barrett Michael P., de Koning, Harry P., Barrett, Michael P., Michael P Barrett, Mäser, P., Mäser Pascal, Matovu, Enock, Nerima Barbara   +23 more
core   +1 more source

Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation

Pharmacological Research, 2023
Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous compounds and drugs across membranes, thus playing a critical role in disease susceptibility and drug response.
Anne T. Nies, Jörg König, Patrick Leuthold, Katja Damme, Stefan Winter, Mathias Haag, Satohiro Masuda, Stephan Kruck, Hannelore Daniel, Britta Spanier, Martin F. Fromm, Jens Bedke, Ken-ichi Inui, Matthias Schwab, Elke Schaeffeler   +14 more
doaj   +1 more source

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2013
Objectives: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Lee, Rebecca S, Burchmore, Richard J S, Natto, Manal J, Eze, Anthonius, Graf, Fabrice, Burchmore, Richard JS, Lee, Rebecca, de Koning, Harry, Glover, Lucy, Mäser, Pascal, Teka, Ibrahim, Barrett, Michael P., Munday, Jane C., Teka, Ibrahim A., De Koning, Harry P., Eze, Anthonius A, Graf, Fabrice E., De Koning, Harry P, Ludin, Philipp, McDonald, Jennifer, MacLeod, Annette, Turner, C Michael R., Munday, Jane C, Natto, Manal J., Lee, Rebecca S., Tait, Andy, Horn, David, Baker, Nicola, Munday, Jane, Turner, C Michael R, Aguinaga Andres, David, Barrett, Michael P, Andrés, David Aguinaga, Burchmore, Richard, Clucas, Caroline, Graf, Fabrice E, Horn, David; id_orcid, Burchmore, Richard J. S., Teka, Ibrahim A, Eze, Anthonius A., Natto, Manal, Turner, C. Michael R., Barrett, Michael   +42 more
core   +1 more source

Equine Drug Transporters: A Mini-Review and Veterinary Perspective

Pharmaceutics, 2020
Xenobiotic transport proteins play an important role in determining drug disposition and pharmacokinetics. Our understanding of the role of these important proteins in humans and pre-clinical animal species has increased substantially over the past few ...
Brielle Rosa
doaj   +1 more source

Expression of drug transporters in intestine and blood [PDF]

, 2005
Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core   +1 more source

Life cycle studies of the hexose transporter of Plasmodiumspecies and genetic validation of their essentiality [PDF]

, 2010
A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT ...
Tewari, R, Tewari, Rita, Tewari, R., Doerig, Christian, Morin, C, Slavic, K., Straschil, U., Straschil, U, Krishna, S., Doerig, C., Krishna, S, Straschil, Ursula, Krishna, Sanjeev, Slavic, K, Reininger, Luc, Morin, C., Reininger, L, Morin, Christophe, Doerig, C, Reininger, L., Slavic, Ksenija   +20 more
core   +1 more source