Results 11 to 20 of about 251,779 (303)

Transporter-Mediated Drug Delivery [PDF]

Molecules, 2023
Transmembrane transport of small organic and inorganic molecules is one of the cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier (SLC) proteins form the largest, albeit very diverse, superfamily with over 400 members ...
Gergely Gyimesi, Matthias A. Hediger
doaj   +2 more sources

Characteristics of novel polymer based on pseudo-polyamino acids GluLa-DPG-PEG600: binding of albumin, biocompatibility, biodistribution and potential crossing the blood-brain barrier in rats [PDF]

The Ukrainian Biochemical Journal, 2017
The aim of our work was to study biological properties of the polymer based on pseudo-polyamino acids GluLa-DPG-PEG600, its ability to bind albumin, as well as its localization in rat body and influence on physio­logical and functional state of rat ...
B. O. Chekh, M. V. Ferens, D. D. Ostapiv, V. Y. Samaryk, S. M. Varvarenko, V. V. Vlizlo   +5 more
doaj   +1 more source

The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy

Pharmaceutics, 2023
Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play a crucial role in the cellular uptake of drugs.
Elena Puris, Gert Fricker, Mikko Gynther
doaj   +1 more source

Drug transporters in pharmacokinetics [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2006
This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms ...
Ernst, Petzinger, Joachim, Geyer
openaire   +2 more sources

Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer

Cells, 2020
An abnormality in hedgehog (Hh) signaling has been implicated in the progression of prostate cancer (PCa) to a more aggressive and therapy-resistant disease.
Santosh Kumar Singh, Jennifer B. Gordetsky, Sejong Bae, Edward P. Acosta, James W. Lillard, Rajesh Singh   +5 more
doaj   +1 more source

Intraluminal Behavior of Various Transporter Substrates in the Rat Gastrointestinal Tract

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Purpose: The aim of this study was to evaluate the intraluminal behavior of various transporter substrates in different regions of the gastrointestinal (GI) tract.
Yusuke Tanaka, Taiki Harada, Kazuhiro Ito, Takanori Kurakazu, Satoshi Kasaoka   +4 more
doaj   +1 more source

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

, 2022
Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or toxicity of many drugs. Numerous mechanisms (e.g., nuclear receptors, epigenetic gene regulation, microRNAs, alternative splicing, post‐translational modifications,
Brouwer, Kim L.R., Neuhoff, Sibylle, Hayden, Elizabeth, Micheline Piquette‐Miller, Piquette‐Miller, Micheline, Sprowl, Jason A., Piquette-Miller, Micheline, Noora Sjöstedt, Henriette E. Meyer zu Schwabedissen, Chitra Saran, Jason A. Sprowl, Raymond Evers, Li, Cindy Yanfei, Saran, Chitra, Elizabeth Hayden, Brouwer, Kim L. R., Shuiying Hu, Cindy Yanfei Li, Sibylle Neuhoff, Oswald, Stefan, Hu, Shuiying, Yue, Wei, Meyer zu Schwabedissen, Henriette E., Wei Yue, Sjöstedt, Noora, zu Schwabedissen, Henriette E. Meyer, Kim L.R. Brouwer, Simone H. Stahl, Evers, Raymond, Stahl, Simone H., Stefan Oswald   +30 more
core   +1 more source

Kidney Drug Transporters in Pharmacotherapy

International Journal of Molecular Sciences, 2023
The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug interactions, as well as constituting direct drug targets.
Joanna Łapczuk-Romańska, Maria Droździk, Stefan Oswald, Marek Droździk   +3 more
openaire   +2 more sources

Food Additives as Inhibitors of Intestinal Drug Transporter OATP2B1 [PDF]

, 2020
Food additives are compounds that are added to food and beverage to improve the taste, color, preservation, or composition. Generally, food additives are considered safe for human use due to safety evaluations conducted by food safety authorities and ...
Koenderink, J.B., Koenderink, Jan B., Feng Deng, Jan B. Koenderink, Pierrot, E., Estelle Pierrot, Marja Hagström, Deng, F., Tikkanen, A., Hagström, Marja, Tikkanen, Alli, Sánchez, V.B., Deng, Feng, Kidron, Heidi, Virginia Barras Sánchez, Sanchez, Virginia Barras, Heidi Kidron, Alli Tikkanen, Hagström, M., Kidron, H., Pierrot, Estelle   +20 more
core   +1 more source

Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability

Asian Journal of Pharmaceutical Sciences, 2020
Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang, Lichun Zhao, Qikun jiang, Yixin Sun, Dongyang Zhao, Mengchi Sun, Zhonggui He, Jin sun, Yang Wang   +8 more
doaj   +1 more source