, 2018 Membrane transporters perform a central function in protecting the body from xenobiotics (either by preventing their absorption, limiting their distribution or promoting their elimination).
Bellera, Carolina Leticia +5 more
core +3 more sources
Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome [PDF]
Frontiers in NeuroscienceBackgroundNeonatal Opioid Withdrawal Syndrome (NOWS) is a consequence of in-utero exposure to prenatal maternal opioids, resulting in the manifestation of symptoms like irritability, feeding problems, tremors, and withdrawal signs.
Uppala Radhakrishna +8 more
doaj +2 more sources
Food Additives Inhibit Intestinal Drug Transporters but Have Limited Effect on In Vitro Drug Permeability. [PDF]
Mol PharmFood additives are chemical substances that are added to processed food to improve its flavor, texture, or appearance. Food additives can inhibit intestinal transporters, such as breast cancer resistance protein (BCRP), multidrug resistance associated ...
Suominen L +3 more
europepmc +2 more sources
Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition
Pharmaceutics, 2023 Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the brain, facilitating their entry into the central nervous system (CNS).
Md Masud Parvez +4 more
doaj +1 more source
Editorial: Diverse functions of drug transporters [PDF]
Frontiers in PharmacologyJeffry C. Granados +2 more
doaj +2 more sources
Drug transporters in pharmacokinetics [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 2006 This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms ...
Ernst, Petzinger, Joachim, Geyer
openaire +2 more sources
Frontiers in Pharmacology, 2021 The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process.
Wei Zou +9 more
doaj +1 more source
Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance
Pharmaceutics, 2020 The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj +1 more source
Expression of Genes for Drug Transporters in the Human Female Genital Tract and Modulatory Effect of Antiretroviral Drugs. [PDF]
PLoS ONE, 2015 Anti-retroviral (ARV) -based microbicides are one of the strategies pursued to prevent HIV-1 transmission. Delivery of ARV drugs to subepithelial CD4+ T cells at concentrations for protection is likely determined by drug transporters expressed in the ...
Karolin Hijazi +10 more
doaj +1 more source
Research and development of drug delivery systems based on drug transporter and nano-formulation
Asian Journal of Pharmaceutical Sciences, 2020 In recent years, the continuous occurrence of multi-drug resistance in the clinic has made people pay more attention to the transporter. Changes in the expression and activity of transporters can cause corresponding changes in drug pharmacokinetics and ...
Yi Peng +6 more
doaj +1 more source