Results 21 to 30 of about 4,751,257 (301)

Research and development of drug delivery systems based on drug transporter and nano-formulation

Asian Journal of Pharmaceutical Sciences, 2020
In recent years, the continuous occurrence of multi-drug resistance in the clinic has made people pay more attention to the transporter. Changes in the expression and activity of transporters can cause corresponding changes in drug pharmacokinetics and ...
Yi Peng, Lu Chen, Sheng Ye, Yu Kang, Junqing Liu, Su Zeng, Lushan Yu   +6 more
doaj   +1 more source

Data-independent acquisition (DIA): An emerging proteomics technology for analysis of drug-metabolizing enzymes and transporters.

Drug Discovery Today : Technologies, 2021
Data-independent acquisition (DIA) proteomics is a recently-developed global mass spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated into pre-defined isolation windows and fragmented; all fragmented ions in each ...
Jiapeng Li, Logan S. Smith, Hao‐Jie Zhu   +2 more
semanticscholar   +1 more source

Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine

Drug Metabolism And Disposition, 2020
The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human intestine are pertinent to determine oral drug bioavailability.
Narciso Couto, Zubida M. Al-Majdoub, Stephanie Gibson, Pamela J Davies, Brahim Achour, M. Harwood, G. Carlson, J. Barber, A. Rostami-Hodjegan, G. Warhurst   +9 more
semanticscholar   +1 more source

Altered Pharmacokinetics of Daunorubicin in Rats with CCl4-Induced Hepatic Injury

Journal of Pharmacy & Pharmaceutical Sciences, 2007
PURPOSE. The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics ...
Min-Koo Choi, Im-Sook Song, Dae-Duk Kim, Suk-Jae Chung, Chang-Koo Shim   +4 more
doaj   +1 more source

Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype

Frontiers in Pharmacology, 2021
ATP-binding cassette (ABC) drug efflux transporters could contribute to low intracellular concentrations of antiretroviral drugs in HIV-1 cell reservoirs and sanctuary sites.
Sana-Kay Whyte-Allman, Rupert Kaul, Reina Bendayan   +2 more
doaj   +1 more source

Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood–Brain Barrier of Human Brain and Glioblastoma

Clinical pharmacology and therapy, 2020
The knowledge of transporter protein expression and function at the human blood–brain barrier (BBB) is critical to prediction of drug BBB penetration and design of strategies for improving drug delivery to the brain or brain tumor.
X. Bao, Jianmei Wu, Youming Xie, Seongho Kim, S. Michelhaugh, Jun Jiang, S. Mittal, N. Sanai, Jing Li   +8 more
semanticscholar   +1 more source

Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters.

Current drug metabolism, 2020
BACKGROUND In clinical practice chloroquine and hydroxychloroquine are often co-administered with other drugs in the treatment of malaria, chronic inflammatory diseases, and COVID-19.
Slobodan Petar Rendic, F. Guengerich
semanticscholar   +1 more source

Intestinal drug transporters in pathological states: an overview

Pharmacological Reports, 2020
Emerging information suggests that gastrointestinal and systemic pathology states may affect expression and function of membrane transporters in the gastrointestinal tract.
M. Droździk, Izabela Czekawy, S. Oswald, A. Droździk   +3 more
semanticscholar   +1 more source

Structural basis for the mechanism of ABC transporters. [PDF]

, 2015
The ATP-binding cassette (ABC) transporters are primary transporters that couple the energy stored in adenosine triphosphate (ATP) to the movement of molecules across the membrane.
Beis, K
core   +1 more source

Recent advances in understanding hepatic drug transport [version 1; referees: 2 approved]

F1000Research, 2016
Cells need to strictly control their internal milieu, a function which is performed by the plasma membrane. Selective passage of molecules across the plasma membrane is controlled by transport proteins.
Bruno Stieger, Bruno Hagenbuch
doaj   +1 more source