Current advances on ABC drug transporters in fish [PDF]
, 2014 Most members of the large ATP-binding cassette (ABC) gene family are transporters involved in substrate translocation across biological membranes. In eukaryotes, ABC proteins functioning as drug transporters are located in the plasma membrane and mediate
Sturm, Armin +2 more
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ABC Transporters in Human Diseases
, 2022 Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and ...
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Role of drug transporters in drug development: a qualitative and quantitative approach
ADMET and DMPK, 2017 Editorial for special issue of the ...
Sumit Basu, Abdul Naveed Shaik
doaj +1 more source
Research progress on reversing tumor resistance based on the epigenetics of drug metabolizing enzymes and transporters [PDF]
Yixue xinzhi zazhi, 2020 The molecular mechanisms related to drug metabolism of tumor resistance include drug inactivation, increase of drug efflux, and decrease of drug uptake, The epigenetic regulation mechanism of drug metabolizing enzymes and drug transporters, such as DNA ...
Xiao-Li ZHENG +3 more
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Expression, activity and pharmacokinetic impact of ocular transporters [PDF]
, 2018 The eye is protected by several tissues that limit the permeability and entry of potentially harmful substances, but also hamper the delivery of drugs in the treatment of ocular diseases.
Arto Urtti +11 more
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The role of drug transporters in the kidney: lessons from tenofovir [PDF]
, 2014 Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients.
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Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery
Pharmaceutics, 2022 Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration.
Rong Lu +4 more
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"In silico" prediction of drug transport across physiological barriers [PDF]
, 2011 Physiological barriers maintain and safeguard homeostasis of certain body compartments by an increased resistance against free diffusion. Distribution and pharmacokinetics of drugs can be altered as well, if they have to cross these barriers in order to ...
Suenderhauf, Claudia
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An update on placental drug transport and its relevance to fetal drug exposure
Medical Review, 2022 Pregnant women are often complicated with diseases that require treatment with medication. Most drugs administered to pregnant women are off-label without the necessary dose, efficacy, and safety information. Knowledge concerning drug transfer across the
Mao Qingcheng, Chen Xin
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Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters [PDF]
, 2009 Imatinib mesylate and nilotinib are highly effective at eradicating the majority of chronic myeloid leukemia (CML) cells; however, neither agent induces apoptosis of primitive CML CD34<sup>+</sup> cells.
Holyoake, T.L. +10 more
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