Results 41 to 50 of about 146,225 (152)
Characterization of SLC transporters in human skin
ADMET and DMPK, 2015 Most identified drug transporters belong to the ATP-binding Cassette (ABC) and Solute Carrier (SLC) families. Recent research indicates that some of these transporters play an important role in the absorption, distribution and excretion of drugs, and are
Marion Alriquet +5 more
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Frontiers in Chemistry, 2020 Transporters expressed in the liver play a major role in drug pharmacokinetics and are a key component of the physiological bile flow. Inhibition of these transporters may lead to drug-drug interactions or even drug-induced liver injury.
Floriane Montanari +6 more
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Transporters involved in hepatobiliary transport of drugs.
Folia Pharmacologica Japonica, 2010 近年，ヒト肝臓において非常に多くのトランスポーターが同定・機能解析されるにつれて，トランスポーターの遺伝子多型や薬物間相互作用による機能変動が薬物動態に与える影響を明らかにするための臨床研究も続々と報告されてきている．それに伴い，異物解毒システムの中でのトランスポーターの重要性が広く認知されてきた．代謝によって消失すると考えられてきた薬物の中にも肝取り込みトランスポーターの基質が含まれていることが明らかとなり，取り込みトランスポーターの機能変動が薬物動態の変化につながる事例が複数報告されてきている．本稿では，ヒト肝臓に発現する主な薬物トランスポーターを紹介すると共に，これらの遺伝子多型・薬物間相互作用が薬物動態や薬効・副作用に与える影響について概説することを目指した．
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Role of drug transporters and drug accumulation in the temporal acquisition of drug resistance
BMC Cancer, 2008 Background Anthracyclines and taxanes are commonly used in the treatment of breast cancer. However, tumor resistance to these drugs often develops, possibly due to overexpression of drug transporters.
Veitch Zachary +6 more
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Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells
Pharmaceutics, 2016 Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transporter
Elodie Jouan +4 more
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Role of Hepatic Drug Transporters in Drug Development [PDF]
The Journal of Clinical Pharmacology, 2016 AbstractHepatic drug transporters can play an important role in pharmacokinetics and the disposition of therapeutic drugs and endogenous substances. Altered function of hepatic drug transporters due to drug‐drug interactions (DDIs), genetic polymorphisms, and disease states can often result in a change in systemic and/or tissue exposure and subsequent ...
Houfu, Liu, Jasminder, Sahi
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Impact of Viral Inflammation on the Expression of Renal Drug Transporters in Pregnant Rats
Pharmaceutics, 2019 Inflammation impacts the expression and function of drug transporters at term-gestation; however, the impact of inflammation on the expression of drug transporters at mid-gestation is largely unknown.
Navaz Karimian Pour +2 more
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Association of drug transporter expression with mortality and progression-free survival in stage IV head and neck squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Drug transporters such as P-glycoprotein (ABCB1) have been associated with chemotherapy resistance and are considered unfavorable prognostic factors for survival of cancer patients.
Rolf Warta +9 more
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A literature review of drug transport mechanisms during lactation
CPT: Pharmacometrics & Systems PharmacologyDespite the benefits of breastfeeding, lactating mothers who take prescribed medications may discontinue breastfeeding due to concerns associated with infant drug exposure in breastmilk. Consolidating the current knowledge of drug transport to breastmilk
Christine Gong +3 more
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Frontiers in Pharmacology, 2018 Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and therapy.
Longfa Kou +6 more
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