Results 51 to 60 of about 158,142 (288)

Role for Drug Transporters in Chemotherapy‐Induced Peripheral Neuropathy

Clinical and Translational Science, 2021
Chemotherapy‐induced peripheral neuropathy (CIPN) is a common and dose‐limiting toxicity to widely used chemotherapeutics. Although the exact molecular mechanism of chemotherapy‐induced peripheral neuropathy remains elusive, there is consensus that it is
Tore B. Stage, Shuiying Hu, Alex Sparreboom, Deanna L. Kroetz   +3 more
doaj   +1 more source

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2013
Objectives: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Lee, Rebecca S, Burchmore, Richard J S, Natto, Manal J, Eze, Anthonius, Graf, Fabrice, Burchmore, Richard JS, Lee, Rebecca, de Koning, Harry, Glover, Lucy, Mäser, Pascal, Teka, Ibrahim, Barrett, Michael P., Munday, Jane C., Teka, Ibrahim A., De Koning, Harry P., Eze, Anthonius A, Graf, Fabrice E., De Koning, Harry P, Ludin, Philipp, McDonald, Jennifer, MacLeod, Annette, Turner, C Michael R., Munday, Jane C, Natto, Manal J., Lee, Rebecca S., Tait, Andy, Horn, David, Baker, Nicola, Munday, Jane, Turner, C Michael R, Aguinaga Andres, David, Barrett, Michael P, Andrés, David Aguinaga, Burchmore, Richard, Clucas, Caroline, Graf, Fabrice E, Horn, David; id_orcid, Burchmore, Richard J. S., Teka, Ibrahim A, Eze, Anthonius A., Natto, Manal, Turner, C. Michael R., Barrett, Michael   +42 more
core   +1 more source

Expression of drug transporters in the human skin: comparison in different species and models and its implication for drug development

ADMET and DMPK, 2017
It is clear that many drug transporters (both ABCs and SLCs) are present in the human skin. Different in vitro skin models can be used to investigate the role of drug transporters in the skin despite quantitative differences in expression profile across ...
Hanan Osman-Ponchet, Alexandre Gaborit, Jean-Michel Linget, Claire E. Wilson   +3 more
doaj   +1 more source

Utilizing in vitro transporter data in IVIVE-PBPK: an overview

ADMET and DMPK, 2017
In vitro-in vivo extrapolation (IVIVE) integrated in physiologically-based pharmacokinetic (PBPK) models have been increasingly used during drug discovery and development processes to predict human pharmacokinetic (PK) parameters.
Pankajini Mallick
doaj   +1 more source

Advances in Pharmacokinetic Mechanisms of Transporter-Mediated Herb-Drug Interactions

Pharmaceuticals, 2022
As the use of herbs has become more popular worldwide, there are increasing reports of herb-drug interactions (HDIs) following the combination of herbs and drugs. The active components of herbs are complex and have a variety of pharmacological activities,
Jie Li, Shuting Wang, Fengjie Tian, Shuang-Qing Zhang, Hongtao Jin   +4 more
doaj   +1 more source

The effects of dietary and herbal phytochemicals on drug transporters

, 2017
Membrane transporter proteins (the ABC transporters and SLC transporters) play pivotal roles in drug absorption and disposition, and thus determine their efficacy and safety.
Paxton, James, Li, Y, Revalde, J
core   +1 more source

Role of Drug Metabolic Enzymes and Transporters in Drug-Drug Interactions Between Antiretroviral and Antituberculosis Drugs

Journal of Advanced Biotechnology and Experimental Therapeutics, 2018
Drug-drug interactions is one of the major determinant in drug development and clinical applications. Individual differences in pharmacokinetics may cause extensive variability in drug efficacy, toxicity and adverse drug reactions, and represent a major ...
Md Masud Parvez, Nazia Kaisar, Jae-Gook Shin   +2 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict drug induced hepatotoxicity

, 2013
Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Jemnitz, Katalin, Monika Szabo, Katalin Jemnitz, Veres, Zsuzsa, Zsuzsa Veres, Baranyai, Zsolt, Zsolt Baranyai, Szabo, Monika, Ferenc Jakab, Jakab, Ferenc   +9 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source