Results 31 to 40 of about 2,100,066 (288)
Altered Pharmacokinetics of Daunorubicin in Rats with CCl4-Induced Hepatic Injury
Journal of Pharmacy & Pharmaceutical Sciences, 2007 PURPOSE. The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics ...
Min-Koo Choi +4 more
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Expression of drug transporters in intestine and blood [PDF]
, 2005 Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core +1 more source
Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype
Frontiers in Pharmacology, 2021 ATP-binding cassette (ABC) drug efflux transporters could contribute to low intracellular concentrations of antiretroviral drugs in HIV-1 cell reservoirs and sanctuary sites.
Sana-Kay Whyte-Allman +2 more
doaj +1 more source
Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core +1 more source
Recent advances in understanding hepatic drug transport [version 1; referees: 2 approved]
F1000Research, 2016 Cells need to strictly control their internal milieu, a function which is performed by the plasma membrane. Selective passage of molecules across the plasma membrane is controlled by transport proteins.
Bruno Stieger, Bruno Hagenbuch
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Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]
, 2006 Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
core +1 more source
Frontiers in Pharmacology, 2016 Membrane drug transporters contribute to the disposition of many drugs. In human liver, drug transport is controlled by two main superfamilies of transporters, the solute carrier transporters (SLC) and the ATP Binding Cassette transporters (ABC). Altered
Eric A Benson +8 more
doaj +1 more source
Role of drug transporters in drug development: a qualitative and quantitative approach
ADMET and DMPK, 2017 Editorial for special issue of the ...
Sumit Basu, Abdul Naveed Shaik
doaj +1 more source
Scientific Reports, 2021 Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile, while basolateral hepatocyte transporters promote the uptake of, or expel, various compounds ...
Csilla Ambrus +4 more
doaj +1 more source
Glutamine transporters as pharmacological targets: From function to drug design
Asian Journal of Pharmaceutical Sciences, 2020 Among the different targets of administered drugs, there are membrane transporters that play also a role in drug delivery and disposition. Moreover, drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity ...
Mariafrancesca Scalise +4 more
doaj +1 more source