The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs [PDF]
, 2009 Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives ...
Sarah Shugarts +161 more
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Frontiers in Pharmacology, 2016 Membrane drug transporters contribute to the disposition of many drugs. In human liver, drug transport is controlled by two main superfamilies of transporters, the solute carrier transporters (SLC) and the ATP Binding Cassette transporters (ABC). Altered
Eric A Benson +8 more
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Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions [PDF]
, 2016 The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents.
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Role of drug transporters in drug development: a qualitative and quantitative approach
ADMET and DMPK, 2017 Editorial for special issue of the ...
Sumit Basu, Abdul Naveed Shaik
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Scientific Reports, 2021 Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile, while basolateral hepatocyte transporters promote the uptake of, or expel, various compounds ...
Csilla Ambrus +4 more
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Research progress on reversing tumor resistance based on the epigenetics of drug metabolizing enzymes and transporters [PDF]
Yixue xinzhi zazhi, 2020 The molecular mechanisms related to drug metabolism of tumor resistance include drug inactivation, increase of drug efflux, and decrease of drug uptake, The epigenetic regulation mechanism of drug metabolizing enzymes and drug transporters, such as DNA ...
Xiao-Li ZHENG +3 more
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Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. [PDF]
, 2014 BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of ...
A Kumari +55 more
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Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]
, 2017 Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K. +5 more
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Glutamine transporters as pharmacological targets: From function to drug design
Asian Journal of Pharmaceutical Sciences, 2020 Among the different targets of administered drugs, there are membrane transporters that play also a role in drug delivery and disposition. Moreover, drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity ...
Mariafrancesca Scalise +4 more
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Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery
Pharmaceutics, 2022 Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration.
Rong Lu +4 more
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