Renal drug transporters and their significance in drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
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Enantioselective Drug Recognition by Drug Transporters [PDF]
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
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Machine Learning Techniques Applied to the Study of Drug Transporters [PDF]
Molecules, 2023 With the advancement of computer technology, machine learning-based artificial intelligence technology has been increasingly integrated and applied in the fields of medicine, biology, and pharmacy, thereby facilitating their development.
Xiaorui Kong +8 more
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Membrane Carriers and Transporters in Kidney Physiology and Disease
Biomedicines, 2021 The growing information suggests that chronic kidney disease may affect expression and function of membrane carriers and transporters in the kidney. The dysfunction of carriers and transporters entails deficient elimination of uremic solutes as well as ...
Marek Drozdzik +2 more
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Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition
Pharmaceutics, 2023 Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the brain, facilitating their entry into the central nervous system (CNS).
Md Masud Parvez +4 more
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Extracellular Vesicles as Drug Transporters. [PDF]
Int J Mol Sci, 2023 Extracellular vesicles (EVs) are lipid bilayer-delimited particles. According to their size and synthesis pathway, EVs can be classified into exosomes, ectosomes (microvesicles), and apoptotic bodies. Extracellular vesicles are of great interest to the scientific community due to their role in cell-to-cell communication and their drug-carrying ...
Nowak M +4 more
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Kidney Drug Transporters in Pharmacotherapy. [PDF]
Int J Mol Sci, 2023 The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug interactions, as well as constituting direct drug targets.
Łapczuk-Romańska J +3 more
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Contribution and expression of renal drug transporters in renal cell carcinoma [PDF]
Frontiers in PharmacologyRenal cell carcinoma (RCC) is a common substantive tumor. According to incomplete statistics, RCC incidence accounts for approximately 90% of renal malignant tumors, and is the second most prevalent major malignant tumor in the genitourinary system ...
Yawen Zuo +7 more
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Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease [PDF]
PharmaceuticsDrug transporters are crucial for facilitating the distribution and elimination of drugs from the body, yet their broader physiological functions remain underexplored.
Christine Blaze, Yan Shu
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Expanding the Gene Expression Profiling of Drug Transporters and Drug-Metabolizing Enzymes to Include the Upper Female Reproductive Tract [PDF]
PharmaceuticsBackground/Objectives: With the ongoing efforts in supporting the discovery of novel targeted drug delivery systems for the upper region of the female reproductive tract (FRT), it is imperative to understand the local drug disposition pathways. We aim to
An Le +6 more
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