Results 11 to 20 of about 2,100,066 (288)
Enantioselective Drug Recognition by Drug Transporters [PDF]
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
doaj +4 more sources
Machine Learning Techniques Applied to the Study of Drug Transporters [PDF]
Molecules, 2023 With the advancement of computer technology, machine learning-based artificial intelligence technology has been increasingly integrated and applied in the fields of medicine, biology, and pharmacy, thereby facilitating their development.
Xiaorui Kong +8 more
doaj +3 more sources
Extracellular Vesicles as Drug Transporters. [PDF]
Int J Mol Sci, 2023 Extracellular vesicles (EVs) are lipid bilayer-delimited particles. According to their size and synthesis pathway, EVs can be classified into exosomes, ectosomes (microvesicles), and apoptotic bodies.
Nowak M +4 more
europepmc +5 more sources
Membrane Carriers and Transporters in Kidney Physiology and Disease
Biomedicines, 2021 The growing information suggests that chronic kidney disease may affect expression and function of membrane carriers and transporters in the kidney. The dysfunction of carriers and transporters entails deficient elimination of uremic solutes as well as ...
Marek Drozdzik +2 more
doaj +2 more sources
Kidney Drug Transporters in Pharmacotherapy. [PDF]
Int J Mol Sci, 2023 The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can ...
Łapczuk-Romańska J +3 more
europepmc +4 more sources
Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease [PDF]
PharmaceuticsDrug transporters are crucial for facilitating the distribution and elimination of drugs from the body, yet their broader physiological functions remain underexplored.
Christine Blaze, Yan Shu
doaj +2 more sources
Contribution and expression of renal drug transporters in renal cell carcinoma [PDF]
Frontiers in PharmacologyRenal cell carcinoma (RCC) is a common substantive tumor. According to incomplete statistics, RCC incidence accounts for approximately 90% of renal malignant tumors, and is the second most prevalent major malignant tumor in the genitourinary system ...
Yawen Zuo +7 more
doaj +2 more sources
Expanding the Gene Expression Profiling of Drug Transporters and Drug-Metabolizing Enzymes to Include the Upper Female Reproductive Tract [PDF]
PharmaceuticsBackground/Objectives: With the ongoing efforts in supporting the discovery of novel targeted drug delivery systems for the upper region of the female reproductive tract (FRT), it is imperative to understand the local drug disposition pathways. We aim to
An Le +6 more
doaj +2 more sources
Renal Drug Transporters and Drug Interactions
Clinical Pharmacokinetics, 2017 Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades.
Thierry Buclin +11 more
core +4 more sources
Membrane transporters play a central role in protecting the body from xenobiotics (either by preventing their absorption, limiting their distribution, or promoting their elimination).
Bellera, Carolina Leticia, Talevi, Alan
core +3 more sources