Results 11 to 20 of about 4,751,257 (301)

Membrane transporters in drug development

Nature Reviews Drug Discovery, 2010
K. Giacomini, Shiew-Mei Huang, D. Tweedie, L. Benet, K. Brouwer, X. Chu, A. Dahlin, R. Evers, V. Fischer, K. Hillgren, K. Hoffmaster, T. Ishikawa, D. Keppler, R. Kim, Caroline A. Lee, M. Niemi, J. Polli, Y. Sugiyama, P. Swaan, J. Ware, S. Wright, S. Yee, M. Zamek-Gliszczynski, Lei Zhang   +23 more
semanticscholar   +3 more sources

Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome [PDF]

Frontiers in Neuroscience
BackgroundNeonatal Opioid Withdrawal Syndrome (NOWS) is a consequence of in-utero exposure to prenatal maternal opioids, resulting in the manifestation of symptoms like irritability, feeding problems, tremors, and withdrawal signs.
Uppala Radhakrishna, Uppala Radhakrishna, Rupa Radhakrishnan, Lavanya V. Uppala, Srinivas B. Muvvala, Jignesh Prajapati, Rakesh M. Rawal, Ray O. Bahado-Singh, Senthilkumar Sadhasivam   +8 more
doaj   +2 more sources

Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition

Pharmaceutics, 2023
Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the brain, facilitating their entry into the central nervous system (CNS).
Md Masud Parvez, Armin Sadighi, Yeseul Ahn, Steve F. Keller, Julius O. Enoru   +4 more
doaj   +1 more source

Editorial: Diverse functions of drug transporters [PDF]

Frontiers in Pharmacology
Jeffry C. Granados, Kit Wun Kathy Cheung, Bhagwat Prasad   +2 more
doaj   +2 more sources

Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects

Archives of Toxicology, 2021
The review presents metabolic properties of Ivermectin (IVM) as substrate and inhibitor of human P450 (P450, CYP) enzymes and drug transporters. IVM is metabolized, both in vivo and in vitro, by C-hydroxylation and O-demethylation reactions catalyzed by ...
Slobodan Petar Rendic
semanticscholar   +1 more source

Disease-Induced Modulation of Drug Transporters at the Blood–Brain Barrier Level

International Journal of Molecular Sciences, 2021
The blood–brain barrier (BBB) is a highly selective and restrictive semipermeable network of cells and blood vessel constituents. All components of the neurovascular unit give to the BBB its crucial and protective function, i.e., to regulate homeostasis ...
Sweilem B. Al Rihani, Lucy I. Darakjian, M. Deodhar, Pamela Dow, J. Turgeon, V. Michaud   +5 more
semanticscholar   +1 more source

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics [PDF]

, 2015
Membrane transporters play an essential role in the transport of endogenous and exogenous compounds, and consequently they mediate the uptake, distribution, and excretion of many drugs. The clinical relevance of transporters in drug disposition and their
Knibbe, C.A.J. (Catherijne), Mooij, M.G. (Miriam), Nies, A.T. (Anne T.), Schaeffeler, E. (Elke), Schwab, M. (Matthias), Tibboel, D. (Dick), Wildt, S.N. (Saskia) de   +6 more
core   +10 more sources

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance

Pharmaceutics, 2020
The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj   +1 more source

Membrane Carriers and Transporters in Kidney Physiology and Disease

Biomedicines, 2021
The growing information suggests that chronic kidney disease may affect expression and function of membrane carriers and transporters in the kidney. The dysfunction of carriers and transporters entails deficient elimination of uremic solutes as well as ...
Marek Drozdzik, Maria Drozdzik, Stefan Oswald   +2 more
doaj   +1 more source

Expression of Genes for Drug Transporters in the Human Female Genital Tract and Modulatory Effect of Antiretroviral Drugs. [PDF]

PLoS ONE, 2015
Anti-retroviral (ARV) -based microbicides are one of the strategies pursued to prevent HIV-1 transmission. Delivery of ARV drugs to subepithelial CD4+ T cells at concentrations for protection is likely determined by drug transporters expressed in the ...
Karolin Hijazi, Anna M Cuppone, Kieron Smith, Maria A Stincarelli, Julia Ekeruche-Makinde, Giulia De Falco, Georgina L Hold, Robin Shattock, Charles G Kelly, Gianni Pozzi, Francesco Iannelli   +10 more
doaj   +1 more source