Results 91 to 100 of about 26,243 (291)
CPT: Pharmacometrics & Systems Pharmacology, 2017 Rosuvastatin is a frequently used probe in transporter‐mediated drug‐drug interaction (DDI) studies. This report describes the development of a physiologically based pharmacokinetic (PBPK) model of rosuvastatin for prediction of pharmacokinetic (PK) DDIs.
Q Wang, M Zheng, T Leil
doaj +1 more source
Advanced Functional Materials, EarlyView.All‐solution‐processed, low‐cost extended short‐wavelength infrared photodetectors are realized by coupling colloidal HgTe quantum dots to plasmonic In2O3:Sn,F nanocrystals. Localized surface plasmon resonances boost and spectrally tailor light absorption between 1500 and 3000 nm, enabling responsivities above 40 A W−1.
Kseniia A. Sergeeva +9 more
wiley +1 more source
Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]
, 2006 Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
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Advanced Functional Materials, EarlyView.The active role of KCl as a neutral electrolyte enables switching the selectivity on a Cu organic framework from C1 to C2+ products during electrocatalytic CO2 reduction. ABSTRACT We introduce a copper‐nicotinate (Cu‐NA) framework as a halogenide‐stabilized Cu+/Cu0 pre‐catalyst for electrocatalytic CO2 reduction with high C2+ selectivity in a “neutral”
Anirudha Shekhawat +11 more
wiley +1 more source
Expression cloning and characterization of a renal organic anion transporter from winter flounder
, 1997 The cDNA coding for a renal p-aminohippurate (PAH) transporter from winter flounder (Pseudopleuronectes americanus), designated fROAT, was cloned by functional expression in Xenopus laevis oocytes.
Werner, A +7 more
core +1 more source
An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network* [PDF]
, 2016 There has been a recent interest in the broader physiological importance of multispecific "drug" transporters of the SLC and ABC transporter families.
Nigam, Sanjay K +10 more
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Frontiers in Pharmacology, 2018 The steroid hormones progestagens, estrogens, androgens, and glucocorticoids as well as their precursor cholesterol are required for successful establishment and maintenance of pregnancy and proper development of the fetus.
Waranya Chatuphonprasert +3 more
doaj +1 more source
Regulation of organic anion transport in the liver.
The Yale journal of biology and medicine, 1997 In several liver diseases the biliary transport is disturbed, resulting in, for example, jaundice and cholestasis. Many of these symptoms can be attributed to altered regulation of hepatic transporters. Organic anion transport, mediated by the canalicular multispecific organic anion transporter (cmoat), has been extensively studied.
Roelofsen, H. +2 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.Innovative hybrid nanoassemblies installed with ferrocene, D‐α‐tocopherol succinate, and phloretin exploit the metabolic vulnerability of triple‐negative breast cancer under glucose starvation. By blocking glucose uptake, this single nanoplatform simultaneously orchestrates apoptosis, disulfidptosis, and ferroptosis to achieve synergistic and ...
Song Yi Lee +10 more
wiley +1 more source
, 1997 OAT-K1, a renal organic anion transporter, which mediates methotrexate uptake, was analyzed for mRNA distribution along microdissected nephron segments and the immunolocalization in isolated plasma membranes from rat kidney.
Kimio Tomita +9 more
core +1 more source