Results 111 to 120 of about 52,147 (304)

Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]

, 2017
We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
core   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability [PDF]

, 2001
Although it was originally believed that thyroid hormones enter target cells by passive diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes.
Docter, R. (Roel), Friesema, E.C.H. (Edith), Hennemann, G. (George), Jong, M. (Marion) de, Krenning, E.P. (Eric), Visser, T.J. (Theo)   +5 more
core   +3 more sources

Regulated Ion‐Diffusion Hydrogels for Subtle and Multimodal Temperature‐Strain Sensing in Wound Monitoring

Advanced Functional Materials, EarlyView.
A soft, dual‐channel hydrogel patch enables simultaneous detection of wound temperature and strain by integrating ion‐diffusion‐mediated thermoelectric and resistive sensing. The conformal design maintains stable performance during motion, capturing subtle inflammatory and mechanical changes for continuous wound monitoring.
Yu Fang, Xinglong Pan, Zhiwei Li, Wanheng Lu, Chang Liu, Yi Zhou, Guo Tian, Ghim Wei Ho   +7 more
wiley   +1 more source

Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells

Pharmaceutics
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes.
Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J. Kelly, Jashvant D. Unadkat   +4 more
doaj   +1 more source

Physiologically‐Based Pharmacokinetic Modeling for the Prediction of a Drug–Drug Interaction of Combined Effects on P‐glycoprotein and Cytochrome P450 3A

CPT: Pharmacometrics & Systems Pharmacology, 2020
Direct oral anticoagulants, such as apixaban and rivaroxaban, are important for the treatment and prophylaxis of venous thromboembolism and to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
Yukio Otsuka, Mary P. Choules, Peter L. Bonate, Kanji Komatsu   +3 more
doaj   +1 more source

Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions [PDF]

, 2016
Organic anion transporting polypeptide (OATP) 1B1 mediates the hepatic uptake of many drugs including lipid-lowering statins. Decreased OATP1B1 transport activity is often associated with increased systemic exposure of statins and statin-induced myopathy.
Abuznait, Alaa H., Alam, Khondoker, Ding, Kai, Li, Lang, Pahwa, Sonia, Wang, Xueying, Yue, Wei, Zhang, Pengyue   +7 more
core   +2 more sources

Engineering Strategies for Stable and Long‐Life Alkaline Zinc‐Based Flow Batteries

Advanced Functional Materials, EarlyView.
Alkaline zinc‐based flow batteries face persistent challenges from unstable zinc deposition, including dendrite growth, passivation, corrosion, and hydrogen evolution, which severely limit cycling stability. Current research addresses these issues through coordinated electrode structuring, electrolyte regulation, and membrane design to control zinc ...
Yuran Bai, Xiaoyu Huo, Xin Long, Enkang Fu, Xusong Gong, Lei Wei, Liang An   +6 more
wiley   +1 more source

Molecular cloning and characterization of the porcine prostaglandin transporter (SLCO2A1): evaluation of its role in F4 mediated neonatal diarrhoea [PDF]

, 2009
Background: Because prostaglandins are involved in many (patho) physiological processes, SLCO2A1 was already characterized in several species in an attempt to unravel specific processes/deficiencies.
Mario Van Poucke, Vesna Melkebeek, Tim Erkens, Alex Van Zeveren, Eric Cox, Luc J Peelman, SK Banu, T Zhu, SG Harris, F Gao, T Matsuoka, S Scafidi, R Lu, VL Schuster, VL Schuster, SK Banu, N Kanai, R Lu, ML Pucci, SK Banu, B Nagy, RA Gibbons, K Rasschaert, GM Jensen, LJ Peelman, M Van Poucke, J Rask-Madsen, GH Rabbani, BS Chan, JK Lunney, S Rozen, M Zuker, M Van Poucke, M Van Poucke, T Erkens, X Huang, JD Thompson, B Hooghe   +37 more
core   +3 more sources

Single‐ and Dual‐Atom Configurations in Atomically Dispersed Catalysts for Lithium–Sulfur Batteries

Advanced Functional Materials, EarlyView.
Single‐atom and dual‐atom‐based atomically dispersed catalysts (ADCs) effectively address the shuttle effect and sluggish redox kinetics in Li–S batteries. With nearly 100% atomic utilization and tunable coordination environments, ADCs enhance LiPSs adsorption, lower conversion barriers, and accelerate sulfur redox reactions.
Haoyang Xu, Zhenfeng Li, Yue Fei, Ali Mohammadi, Ge Li   +4 more
wiley   +1 more source