Results 21 to 30 of about 52,147 (304)

Interaction of Organic Cations with Organic Anion Transporters [PDF]

Journal of Biological Chemistry, 2009
Studies of the organic anion transporters (Oats) have focused mainly on their interactions with organic anionic substrates. However, as suggested when Oat1 was originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) J. Biol. Chem.
Sun-Young, Ahn, Satish A, Eraly, Igor, Tsigelny, Sanjay K, Nigam   +3 more
openaire   +2 more sources

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

Interactions of Human Organic Anion Transporters With Aristolochic Acids

Journal of Pharmacological Sciences, 2010
Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu, Michio Takeda, Ritsuo Nishida, Rie Noshiro-Kofuji, Masaaki Yoshida, Shiro Ueda, Toshiyuki Fukutomi, Naohiko Anzai, Hitoshi Endou   +8 more
doaj   +1 more source

Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict drug induced hepatotoxicity [PDF]

, 2013
Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Baranyai, Zsolt, Jakab, Ferenc, Jemnitz, Katalin, Szabo, Monika, Veres, Zsuzsa   +4 more
core   +5 more sources

Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate

Journal of Pharmacological Sciences, 2008
In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver.
Rafiqul Islam, Naohiko Anzai, Nesar Ahmed, Babu Ellapan, Chun Ji Jin, Sunena Srivastava, Daisaku Miura, Toshiyuki Fukutomi, Yoshikatsu Kanai, Hitoshi Endou   +9 more
doaj   +1 more source

Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor. [PDF]

, 2017
About 50% of the world's arable land is strongly acidic (pH ≤ 5). The low pH solubilizes root-toxic ionic aluminium (Al3+) species from clay minerals, driving the evolution of counteractive adaptations in cultivated crops.
Chang, Geoffrey, Doshi, Rupak, Garza, Denisse M, Kochian, Leon V, McGrath, Aaron P, Piñeros, Miguel, Szewczyk, Paul   +6 more
core   +3 more sources

Torasemide Transport by Organic Anion Transporters Contributes to Hyperuricemia [PDF]

Journal of the American Society of Nephrology, 2007
The high renal clearance of torasemide, the most potent loop diuretic, suggests active tubular secretion in the proximal tubule. Previous studies implicated the organic anion transporters (OAT) in this process; human OAT1 (hOAT1) and hOAT3 are found on the basolateral surface of proximal ...
Hagos, Yohannes, Bahn, Andrew, Vormfelde, Stefan Viktor, Brockmoeller, Juergen, Burckhardt, Gerhard   +4 more
openaire   +3 more sources

Preclinical assessment of drug–drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist

Clinical and Translational Science, 2023
The objective of the current study was to identify potential drug–drug interactions (DDIs) with the drug candidate fb‐PMT, a novel anticancer thyrointegrin αvß3 antagonist.
Kazutoshi Fujioka, Mostafa I. Fekry, Jeanne M. Rumsey, Toni Steiner, David Thompson, Shaker A. Mousa   +5 more
doaj   +1 more source

Hypouricemic Effects of Chrysanthemum indicum L. and Cornus officinalis on Hyperuricemia-Induced HepG2 Cells, Renal Cells, and Mice

Plants, 2021
Hyperuricemia, abnormally excess accumulation of uric acid, is caused by an imbalance between the production and excretion of uric acid and is a major cause of gout. We compared the effects of extracts from Chrysanthemum indicum L.
Ok-Kyung Kim, Jeong-Moon Yun, Minhee Lee, Dakyung Kim, Jeongmin Lee   +4 more
doaj   +1 more source

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Adachi Y, Brendel C, Christian Zimmermann, Christoph Beglinger, Denk GU, Denson LA, Dietrich CG, Dietrich CG, Ee PL, Frank Lehmann, Freeman LA, Geier A, Gutmann H, Heike Gutmann, Hruz P, Imai Y, Janvilisri T, Jonker JW, Juergen Drewe, Jung D, Jung D, Kamisako T, Klucken J, Li N, Lown KS, Lu TT, Luigi Terracciano, Maliepaard M, Miyake K, Petr Hruz, Plebani M, Popowski K, Schellens JH, Smith M, Stedman CA, Stellaard F, Suzuki M, Taipalensuu J, Tanaka Y, Tanaka Y, Trauner M, Ulrich Beuers, van Herwaarden AE, Volk EL, Wagner M, Xie W, Yu L, Zimmermann C, Zollner G   +48 more
core   +1 more source