Results 21 to 30 of about 26,243 (291)

Interactions of organophosphate flame retardants with human drug transporters

Ecotoxicology and Environmental Safety, 2023
Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible
Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère, Olivier Fardel   +6 more
doaj   +1 more source

Organic Anion-Transporting Polypeptides [PDF]

, 2014
Organic anion-transporting polypeptides or OATPs are central transporters in the disposition of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of endogenous substrates. The critical role of OATPs in drug disposition has spurred research both in academia and in the pharmaceutical industry.
Stieger Bruno, Hagenbuch Bruno
openaire   +4 more sources

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance

Pharmaceutics, 2020
The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj   +1 more source

Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion–transporting polypeptides [PDF]

Journal of Biological Chemistry, 2020
The organic anion transporters (OATs) and organic anion-transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles in handling various endogenous and exogenous compounds of anionic charge. The OATs and OATPs are often implicated in drug therapy by impacting the pharmacokinetics of clinically ...
Wooin Lee, Jeong-min Ha, Yuichi Sugiyama
openaire   +2 more sources

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

Pharmacology Research & Perspectives, 2021
Zanubrutinib is a highly selective, potent, orally available, targeted covalent inhibitor (TCI) of Bruton's tyrosine kinase (BTK). This work investigated the in vitro drug metabolism and transport of zanubrutinib, and its potential for clinical drug–drug
Heather Zhang, Ying C. Ou, Dan Su, Fan Wang, Lai Wang, Srikumar Sahasranaman, Zhiyu Tang   +6 more
doaj   +1 more source

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters

Viruses, 2021
Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro ...
Kelly Bleasby, Robert Houle, Michael Hafey, Meihong Lin, Jingjing Guo, Bing Lu, Rosa I. Sanchez, Kerry L. Fillgrove   +7 more
doaj   +1 more source

Identification of steroid sulfate transport processes in the human mammary gland [PDF]

, 2003
Circulating hormones and local biotransformation of steroid precursors are both sources of estrogen in human mammary tissue. Estrone-3-sulfate (E(1)S) is an important estrogenic form in premenopausal women, and dehydroepiandrosterone sulfate (DHEAS ...
Pizzagalli, F., Meier, P. J., Varga, Z., Huber, R. D., Folkers, G., St-Pierre, M. V.   +5 more
core   +1 more source

Impaired Transport Activity of Human Organic Anion Transporters (OATs) and Organic Anion Transporting Polypeptides (OATPs) by Wnt Inhibitors [PDF]

Journal of Pharmaceutical Sciences, 2021
The Wnt/β-catenin signaling pathway is dysregulated in diseases and Wnt inhibitors like PRI-724 are in clinical development. This study evaluated the regulatory actions of PRI-724 and other Wnt inhibitors on the transport activity of human renal Organic anion transporters (OATs) and Organic anion transporting polypeptides (OATPs).
Youmna, Ali, Tahiatul, Shams, Zhengqi, Cheng, Yue, Li, Chelsea Siu-Wai, Chun, Wenying, Shu, Xiaofeng, Bao, Ling, Zhu, Michael, Murray, Fanfan, Zhou   +9 more
openaire   +2 more sources

Interactions of Human Organic Anion Transporters With Aristolochic Acids

Journal of Pharmacological Sciences, 2010
Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu, Michio Takeda, Ritsuo Nishida, Rie Noshiro-Kofuji, Masaaki Yoshida, Shiro Ueda, Toshiyuki Fukutomi, Naohiko Anzai, Hitoshi Endou   +8 more
doaj   +1 more source

Preclinical assessment of drug–drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist

Clinical and Translational Science, 2023
The objective of the current study was to identify potential drug–drug interactions (DDIs) with the drug candidate fb‐PMT, a novel anticancer thyrointegrin αvß3 antagonist.
Kazutoshi Fujioka, Mostafa I. Fekry, Jeanne M. Rumsey, Toni Steiner, David Thompson, Shaker A. Mousa   +5 more
doaj   +1 more source