Results 11 to 20 of about 26,243 (291)

Organic Anion Transporter Family: Current Knowledge

Journal of Pharmacological Sciences, 2006
.: Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in ...
Naohiko Anzai, Yoshikatsu Kanai, Hitoshi Endou   +2 more
doaj   +5 more sources

Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate

Journal of Pharmacological Sciences, 2008
In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver.
Rafiqul Islam, Naohiko Anzai, Nesar Ahmed, Babu Ellapan, Chun Ji Jin, Sunena Srivastava, Daisaku Miura, Toshiyuki Fukutomi, Yoshikatsu Kanai, Hitoshi Endou   +9 more
doaj   +2 more sources

AG490, a JAK2-specific inhibitor, downregulates the expression and activity of organic anion transporter-3

Journal of Pharmacological Sciences, 2018
Human organic anion transporter-3 (hOAT3) is richly expressed in the kidney, where it plays critical roles in the secretion of clinically important drugs, including anti-viral therapeutics, anti-cancer drugs, antibiotics, antihypertensives, and anti ...
Jinghui Zhang, Chenchang Liu, Guofeng You   +2 more
doaj   +2 more sources

Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology. [PDF]

Int J Mol Sci, 2023
The sodium-dependent organic anion transporter (SOAT, gene symbol SLC10A6) specifically transports 3′- and 17′-monosulfated steroid hormones, such as estrone sulfate and dehydroepiandrosterone sulfate, into specific target cells.
Wannowius M, Karakus E, Aktürk Z, Breuer J, Geyer J.   +4 more
europepmc   +3 more sources

Renal organic anion transporter 1: clinical relevance and the underlying mechanisms in chronic kidney disease. [PDF]

BMC Nephrol
Organic anion transporter 1 (OAT1), primarily found in the renal proximal tubule, is essential for the excretion of various uremic toxins that contribute to the onset and progression of chronic kidney disease (CKD).
You C, Guo J, Xun Y.
europepmc   +2 more sources

Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat. [PDF]

Biopharm Drug Dispos
Ikemura K., Kobayashi S., Wang D., et al. Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat.
Ikemura K, Kobayashi S, Wang D, Okuda M.
europepmc   +3 more sources

The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of Moringa oleifera Lam. Leaves against Hyperuricemia Mice

Molecules, 2022
The aim of this study is to evaluate the anti-hyperuricemia effect and clarify the possible mechanisms of flavonoids and phenolics of MOL (MOL-FP) in mice.
Xiaowei Luo, Lipeng Zhou, Shukai Wang, Jing Yuan, Zihao Chang, Qian Hu, Yinxin Chen, Yuqi Liu, Ya Huang, Baojin Wang, Ye Gao, Zhaohui Wang, Yitong Cui, Yue Liu, Lanzhen Zhang   +14 more
doaj   +1 more source

Interaction of Organic Cations with Organic Anion Transporters [PDF]

Journal of Biological Chemistry, 2009
Studies of the organic anion transporters (Oats) have focused mainly on their interactions with organic anionic substrates. However, as suggested when Oat1 was originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) J. Biol. Chem.
Sun-Young, Ahn, Satish A, Eraly, Igor, Tsigelny, Sanjay K, Nigam   +3 more
openaire   +2 more sources

Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3− Exchange [PDF]

Journal of Biological Chemistry, 1997
Organic anion transporting polypeptide (oatp) is an integral membrane protein cloned from rat liver that mediates Na+-independent transport of organic anions such as sulfobromophthalein and taurocholic acid. Previous studies in rat hepatocytes suggested that organic anion uptake is associated with base exchange.
L M, Satlin, V, Amin, A W, Wolkoff
openaire   +2 more sources

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. [PDF]

PLoS ONE, 2017
Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of
Lisa Chedik, Arnaud Bruyere, Marc Le Vee, Bruno Stieger, Claire Denizot, Yannick Parmentier, Sophie Potin, Olivier Fardel   +7 more
doaj   +1 more source