Results 11 to 20 of about 52,147 (304)

The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of Moringa oleifera Lam. Leaves against Hyperuricemia Mice

Molecules, 2022
The aim of this study is to evaluate the anti-hyperuricemia effect and clarify the possible mechanisms of flavonoids and phenolics of MOL (MOL-FP) in mice.
Xiaowei Luo, Lipeng Zhou, Shukai Wang, Jing Yuan, Zihao Chang, Qian Hu, Yinxin Chen, Yuqi Liu, Ya Huang, Baojin Wang, Ye Gao, Zhaohui Wang, Yitong Cui, Yue Liu, Lanzhen Zhang   +14 more
doaj   +1 more source

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. [PDF]

PLoS ONE, 2017
Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of
Lisa Chedik, Arnaud Bruyere, Marc Le Vee, Bruno Stieger, Claire Denizot, Yannick Parmentier, Sophie Potin, Olivier Fardel   +7 more
doaj   +1 more source

Interactions of organophosphate flame retardants with human drug transporters

Ecotoxicology and Environmental Safety, 2023
Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible
Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère, Olivier Fardel   +6 more
doaj   +1 more source

Organic Anion-Transporting Polypeptides [PDF]

, 2014
Organic anion-transporting polypeptides or OATPs are central transporters in the disposition of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of endogenous substrates. The critical role of OATPs in drug disposition has spurred research both in academia and in the pharmaceutical industry.
Stieger Bruno, Hagenbuch Bruno
openaire   +3 more sources

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance

Pharmaceutics, 2020
The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj   +1 more source

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

Pharmacology Research & Perspectives, 2021
Zanubrutinib is a highly selective, potent, orally available, targeted covalent inhibitor (TCI) of Bruton's tyrosine kinase (BTK). This work investigated the in vitro drug metabolism and transport of zanubrutinib, and its potential for clinical drug–drug
Heather Zhang, Ying C. Ou, Dan Su, Fan Wang, Lai Wang, Srikumar Sahasranaman, Zhiyu Tang   +6 more
doaj   +1 more source

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters

Viruses, 2021
Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro ...
Kelly Bleasby, Robert Houle, Michael Hafey, Meihong Lin, Jingjing Guo, Bing Lu, Rosa I. Sanchez, Kerry L. Fillgrove   +7 more
doaj   +1 more source

Organic Anion and Cation Transporter Expression and Function During Embryonic Kidney Development and in Organ Culture Model Systems [PDF]

, 2006
Background Organic anion and cation transporters (OATs, OCTs and OCTNs) mediate the proximal tubular secretion of numerous clinically important compounds, including various commonly prescribed pharmaceuticals.
Bush, Kevin T., Eraly, Satish A., Nigam, Sanjay K., Sweet, Douglas H.   +3 more
core   +2 more sources

Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]

, 1993
Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Aronson, Assaf, Ballanyi, Beaudry, Bonanno, Cabantchik, Chester, Combs, de Hemptinne, Deuticke, Deuticke, Dubinsky, Edlund, Grinstein, Halestrap, Halestrap, Halestrap, Halestrap, Halestrap, Hansen, Imai, Johnson, Juel, Kraig, Krnjević, Kuhr, Marrannes, Mason, Mutch, Poole, Poole, Poole, Poole, Raley-Susman, Roos, Roth, Scheller, Schneider, Schneider, Smith, Spencer, Strupp, Trosper, Walsh, Walz, Walz   +45 more
core   +1 more source

Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]

, 2016
BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc, Hagerty, David T, Hyndman, David, Iverson, Cory, Liu, Sha, Manhard, Kimberly, Miner, Jeffrey N, Nanavati, Payal, Quart, Barry, Shen, Zancong, Tan, Philip K, Terkeltaub, Robert, Yeh, Li-Tain   +12 more
core   +2 more sources