Results 11 to 20 of about 2,181,867 (291)
Drug Design, Development and Therapy, 2015 Hyeon-Uk Jeong,1 Mihwa Kwon,2 Yongnam Lee,3 Ji Seok Yoo,3 Dae Hee Shin,3 Im-Sook Song,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences ...
Jeong HU +6 more
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Organic Anion Transporter Family: Current Knowledge
Journal of Pharmacological Sciences, 2006 .: Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in ...
Naohiko Anzai +2 more
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A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A
Journal of Pharmacological Sciences, 2011 .: In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system.
Promsuk Jutabha +6 more
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Journal of Pharmacological Sciences, 2004 Human organic anion transporter OAT4 is expressed in the kidney and placenta and mediates high-affinity transport of estrone-3-sulfate (E1S). Because a previous study demonstrated no trans-stimulatory effects by E1S, the mode of organic anion transport ...
Sophapun Ekaratanawong +8 more
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Journal of Pharmacological Sciences, 2008 In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver.
Rafiqul Islam +9 more
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Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
Journal of Pharmacological Sciences, 2008 Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa +9 more
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Interactions of Human Organic Anion Transporters With Aristolochic Acids
Journal of Pharmacological Sciences, 2010 Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu +8 more
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Journal of Pharmacological Sciences, 2018 Human organic anion transporter-3 (hOAT3) is richly expressed in the kidney, where it plays critical roles in the secretion of clinically important drugs, including anti-viral therapeutics, anti-cancer drugs, antibiotics, antihypertensives, and anti ...
Jinghui Zhang +2 more
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Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver. [PDF]
World J Clin Cases, 2019 Organic anion transporters (OATs) and organic anion transporter polypeptides (OATPs) are classified within two SLC superfamilies, namely, the SLC22A superfamily and the SLCO superfamily (formerly the SLC21A family), respectively. They are expressed in many tissues, such as the liver and kidney, and mediate the absorption and excretion of many ...
Li TT, An JX, Xu JY, Tuo BG.
europepmc +3 more sources
Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat. [PDF]
Biopharm Drug DisposIkemura K., Kobayashi S., Wang D., et al. Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat.
Ikemura K, Kobayashi S, Wang D, Okuda M.
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