Results 31 to 40 of about 2,181,867 (291)

Impaired Transport Activity of Human Organic Anion Transporters (OATs) and Organic Anion Transporting Polypeptides (OATPs) by Wnt Inhibitors [PDF]

Journal of Pharmaceutical Sciences, 2021
The Wnt/β-catenin signaling pathway is dysregulated in diseases and Wnt inhibitors like PRI-724 are in clinical development. This study evaluated the regulatory actions of PRI-724 and other Wnt inhibitors on the transport activity of human renal Organic anion transporters (OATs) and Organic anion transporting polypeptides (OATPs).
Youmna, Ali, Tahiatul, Shams, Zhengqi, Cheng, Yue, Li, Chelsea Siu-Wai, Chun, Wenying, Shu, Xiaofeng, Bao, Ling, Zhu, Michael, Murray, Fanfan, Zhou   +9 more
openaire   +2 more sources

Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats

Pharmaceutical Biology, 2019
Context: Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia.
Cong Fang, Lanying Chen, Mingzhen He, Yingying Luo, Mengjing Zhou, Ni Zhang, Jinfeng Yuan, Huiling Wang, Yongyan Xie   +8 more
doaj   +1 more source

Hypouricemic Effects of Chrysanthemum indicum L. and Cornus officinalis on Hyperuricemia-Induced HepG2 Cells, Renal Cells, and Mice

Plants, 2021
Hyperuricemia, abnormally excess accumulation of uric acid, is caused by an imbalance between the production and excretion of uric acid and is a major cause of gout. We compared the effects of extracts from Chrysanthemum indicum L.
Ok-Kyung Kim, Jeong-Moon Yun, Minhee Lee, Dakyung Kim, Jeongmin Lee   +4 more
doaj   +1 more source

Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E2 Transport Pathway

Journal of Pharmacological Sciences, 2007
Renal organic anion transporters play an important role in the handling of a number of endogenous and exogenous anionic substances in the kidney. In this study, we investigated prostaglandin E2 (PGE2) transport properties and intrarenal localization of ...
Sirinun Nilwarangkoon, Naohiko Anzai, Katsuko Shiraya, Erkang Yu, Rafiqul Islam, Seok Ho Cha, Maristela Lika Onozato, Daisaku Miura, Promsuk Jutabha, Akihiro Tojo, Yoshikatsu Kanai, Hitoshi Endou   +11 more
doaj   +1 more source

Preclinical assessment of drug–drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist

Clinical and Translational Science, 2023
The objective of the current study was to identify potential drug–drug interactions (DDIs) with the drug candidate fb‐PMT, a novel anticancer thyrointegrin αvß3 antagonist.
Kazutoshi Fujioka, Mostafa I. Fekry, Jeanne M. Rumsey, Toni Steiner, David Thompson, Shaker A. Mousa   +5 more
doaj   +1 more source

Torasemide Transport by Organic Anion Transporters Contributes to Hyperuricemia [PDF]

Journal of the American Society of Nephrology, 2007
The high renal clearance of torasemide, the most potent loop diuretic, suggests active tubular secretion in the proximal tubule. Previous studies implicated the organic anion transporters (OAT) in this process; human OAT1 (hOAT1) and hOAT3 are found on the basolateral surface of proximal ...
Hagos, Yohannes, Bahn, Andrew, Vormfelde, Stefan Viktor, Brockmoeller, Juergen, Burckhardt, Gerhard   +4 more
openaire   +3 more sources

SLC2A9 is a high-capacity urate transporter in humans [PDF]

, 2008
Background Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have
Doblado M, Kumari, Meena, Charchar, Fadi J, Samani, NJ, Elliott Paul, Kooner J, M. Marmot (7611368), Eyheramendy S, Dobson Richard J, Marmot, Michael, Connell, JM, Philip Howard, Caulfield, Mark J., J. Chambers (3846385), Connell John M, Munroe, Patricia B, John Chambers, Marmot Michael, Dobson, RJ, Charchar Fadi J, Doblado, M, Kumari, M, Morris Brown, Dobson RJ, Elliott, Paul, Gudrun Veldre, R. J. Dobson (7602557), Caulfield MJ, Iacone, Roberto, Laan, Maris, Lathrop, G. Mark, A. Dominiczak (7611551), Kooner, Jaspal, P. Strazzullo (7611365), Farrall Martin, Viigimaa Margus, Brown, M, Samani, Nilesh J., Francesco P Cappuccio, Lann, Maris, P. Howard (7611350), Nilesh J. Samani (7579793), Farrall, M, K. H. Moley (7611569), Newhouse, Stephen J, Munroe PB, Veldre, Gudrun, Wallace Chris, Evans, S, Chambers, John, Howard P, Martin Farrall, Deb O'Neill, Witkowska K, Newhouse, SJ, M. Laan (7602659), Maris Laan, Charchar FJ, Munroe Patricia B, M. Viigimaa (7602620), Cheeseman C., Dominiczak A, M. Doblado (7611566), Evans Sarah, Onipinla A, Shaw-Hawkins Sue, Lathrop GM, Evans, Sarah, Iacone Roberto, Marmot, M, C. Wallace (7602467), Munroe, PB, Witkowska, K, Wallace, C, M. Farrall (6522599), Moley, KH, Charchar, Fadi J., Brunner E, Eric Brunner, Chris Wallace, Brunner Eric, G. M. Lathrop (7611353), O'Neill, D, Dobson, Richard J., G Mark Lathrop, Richard J Dobson, F. J. Charchar (7591784), Howard Philip, Cappuccio FP, Cappuccio, Francesco, Evans S, E. Brunner (7611371), Lathrop, GM, S. Shaw-Hawkins (7602380), Org Elin, Chambers John, Moley, Kelle Harbert, F. P. Cappuccio (7611356), Wallace, Chris, Connell, J. M. C., Cheeseman, Chris, Sue Shaw-Hawkins, Stephen J Newhouse, Dobson, Richard, Samani NJ, Kelle H Moley, Patricia B Munroe, Howard, P, Wallace C, Cappuccio Francesco P, Veldre Gudrun, Caulfield Mark J, Manuel Doblado, Moley Kelle H, Elin Org, Viigimaa, M, S. J. Newhouse (7602371), Onipinla, Abiodun, Michael Marmot, Elliot, Paul, Dominiczak, A, Veldre G, R. Iacone (7611362), Abiodun Onipinla, Mark J Caulfield, Sarah Evans, Marmot M, Cheeseman Chris, Kooner, J, Brown Morris, J. Kooner (7609340), Laan, M, Moley, Kelle H, Witkowska Kate, Moley, Kelle H., C. Ji (7611359), Shaw Hawkins, Sue, Kumari Meena, P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Pasquale Strazzullo, Laan M, D. O'Neill (7611560), Brown, M. J. (Morris Jonathan), Shaw-Hawkins, Sue, Chris Cheeseman, Samani, Nilesh J, Strazzullo, P, Dobson, Richard; id_orcid, Cappuccio, Francesco P., K. Witkowska (7611563), Munroe, Patricia B., Cappucio, Francesco P., Charchar, FJ, Brunner, Eric, Newhouse SJ, Witkowska, Kate, Kate Witkowska, O'Neill, Deb, Moley KH, Elliott, P, Org, E, Lathrop G. Mark, Paul Elliott, E. Org (7602644), O'Neill Deb, Doblado Manuel, Caulfield, Mark, Marmot, Michael G., John M Connell, Onipinla Abiodun, Caulfield, MJ, Org E, J. M. Connell (7602551), Cappuccio, FP, Newhouse, Stephen, Onipinla, A, Susana Eyheramendy, Newhouse, Stephen J., Brown, Morris, Jaspal Kooner, S. Eyheramendy (7611197), Roberto Iacone, Samani Nilesh J, Fadi J Charchar, Shaw Hawkins S, Strazullo, Pasquale, Cheeseman, C, Elliott P, Strazzullo Pasquale, M. Brown (3020991), Ji Chen, Cheeseman, Chris (Christopher I.), Meena Kumari, Chambers, John, MD, Org, Elin, Anna Dominiczak, S. Evans (6370628), Dominiczak Anna, Iacone, R, Dobson, Richard J, Brunner, E, Margus Viigimaa, P. Elliott (1293702), Viigimaa, Margus, Chen Ji, Connell, John M., Farrall M, Eyheramendy, S, M. J. Caulfield (7602383), Connell, John M, O'Neill D, Eyheramendy, Susana, Chambers J, C. Cheeseman (7611572), Laan Maris, Newhouse Stephen J, Caulfield, Mark J, Ji, C, Doblado, Manuel, Shaw-Hawkins, S, Dominiczak, A. F., Ji C, G. Veldre (7602656), Lathrop, G Mark, Eyheramendy Susana, A. Onipinla (7602377), Cappuccio, Francesco P, M. Kumari (7602503), Kooner Jaspal, Dominiczak, Anna, Nilesh J Samani, Brown M, Chambers, J, Viigimaa M, Strazzullo, Pasquale, Connell JM, Howard, Philip, Ji, Chen, Kumari M, O'Neill, Deb   +241 more
core   +1 more source

The Evolving View of Uremic Toxicity

Toxins, 2022
Indoxyl sulfate, closely related to indigo, a dye valued for it binding to cloth, has been recognized as a protein-bound solute bound to albumin, present in increased concentration in the serum of patients with impaired glomerular filtration (13).
Bjorn Meijers, Jerome Lowenstein
doaj   +1 more source

Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic anion transporter 3 through protein kinase A signaling pathway

Acta Pharmaceutica Sinica B, 2020
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body.
Jinghui Zhang, Zhou Yu, Guofeng You
doaj   +1 more source

Altered Brain Penetration of Diclofenac and Mefenamic Acid, but Not Acetaminophen, in Shiga-Like Toxin II-Treated Mice

Journal of Pharmacological Sciences, 2005
It is well accepted that bacterial and virus infections elevate the levels of cytokines in serum and cerebrospinal fluids. Such high levels of cytokines might alter the integrity of the blood-brain barrier (BBB) and/or blood-cerebrospinal fluid barrier ...
Masaya Fukuda, Kiyoyuki Kitaichi, Fumie Abe, Yohei Fujimoto, Kenji Takagi, Kenzo Takagi, Tsuneo Morishima, Takaaki Hasegawa   +7 more
doaj   +1 more source