Results 31 to 40 of about 26,243 (291)

Hypouricemic Effects of Chrysanthemum indicum L. and Cornus officinalis on Hyperuricemia-Induced HepG2 Cells, Renal Cells, and Mice

Plants, 2021
Hyperuricemia, abnormally excess accumulation of uric acid, is caused by an imbalance between the production and excretion of uric acid and is a major cause of gout. We compared the effects of extracts from Chrysanthemum indicum L.
Ok-Kyung Kim, Jeong-Moon Yun, Minhee Lee, Dakyung Kim, Jeongmin Lee   +4 more
doaj   +1 more source

Torasemide Transport by Organic Anion Transporters Contributes to Hyperuricemia [PDF]

Journal of the American Society of Nephrology, 2007
The high renal clearance of torasemide, the most potent loop diuretic, suggests active tubular secretion in the proximal tubule. Previous studies implicated the organic anion transporters (OAT) in this process; human OAT1 (hOAT1) and hOAT3 are found on the basolateral surface of proximal ...
Hagos, Yohannes, Bahn, Andrew, Vormfelde, Stefan Viktor, Brockmoeller, Juergen, Burckhardt, Gerhard   +4 more
openaire   +3 more sources

Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats

Pharmaceutical Biology, 2019
Context: Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia.
Cong Fang, Lanying Chen, Mingzhen He, Yingying Luo, Mengjing Zhou, Ni Zhang, Jinfeng Yuan, Huiling Wang, Yongyan Xie   +8 more
doaj   +1 more source

Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E2 Transport Pathway

Journal of Pharmacological Sciences, 2007
Renal organic anion transporters play an important role in the handling of a number of endogenous and exogenous anionic substances in the kidney. In this study, we investigated prostaglandin E2 (PGE2) transport properties and intrarenal localization of ...
Sirinun Nilwarangkoon, Naohiko Anzai, Katsuko Shiraya, Erkang Yu, Rafiqul Islam, Seok Ho Cha, Maristela Lika Onozato, Daisaku Miura, Promsuk Jutabha, Akihiro Tojo, Yoshikatsu Kanai, Hitoshi Endou   +11 more
doaj   +1 more source

The Evolving View of Uremic Toxicity

Toxins, 2022
Indoxyl sulfate, closely related to indigo, a dye valued for it binding to cloth, has been recognized as a protein-bound solute bound to albumin, present in increased concentration in the serum of patients with impaired glomerular filtration (13).
Bjorn Meijers, Jerome Lowenstein
doaj   +1 more source

Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic anion transporter 3 through protein kinase A signaling pathway

Acta Pharmaceutica Sinica B, 2020
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body.
Jinghui Zhang, Zhou Yu, Guofeng You
doaj   +1 more source

Altered Brain Penetration of Diclofenac and Mefenamic Acid, but Not Acetaminophen, in Shiga-Like Toxin II-Treated Mice

Journal of Pharmacological Sciences, 2005
It is well accepted that bacterial and virus infections elevate the levels of cytokines in serum and cerebrospinal fluids. Such high levels of cytokines might alter the integrity of the blood-brain barrier (BBB) and/or blood-cerebrospinal fluid barrier ...
Masaya Fukuda, Kiyoyuki Kitaichi, Fumie Abe, Yohei Fujimoto, Kenji Takagi, Kenzo Takagi, Tsuneo Morishima, Takaaki Hasegawa   +7 more
doaj   +1 more source

Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney [PDF]

, 2006
The organic anion transporters (OATs) are expressed in various tissues, primarily in the kidney and liver, but they are also expressed in the placenta, small intestine, and the choroid plexus, which are all epithelial tissues that transport xenobiotics ...
이운규
core   +1 more source

Effects of polysaccharides-riched Prunus mume fruit juice concentrate on uric acid excretion and gut microbiota in mice with adenine-induced chronic kidney disease

Current Research in Food Science, 2022
The present study aimed to determine the effects of polysaccharides-riched Prunus mume fruit juice concentrate (PFC) on uric acid (UA) excretion and the gut microbiota in mice with chronic kidney disease (CKD).
Yan Huang, Chen-Xi Wu, Lu Guo, Xiao-Xi Zhang, Dao-Zong Xia   +4 more
doaj   +1 more source

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers

Frontiers in Pharmacology, 2017
Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Tea Lanišnik Rižner, Theresia Thalhammer, Csilla Özvegy-Laczka   +2 more
doaj   +1 more source