Results 41 to 50 of about 4,120 (207)

Investigation into the predominate mechanism of OAT1 inhibition (1064.15)

The FASEB Journal, 2014
Renal tubular drug secretion mediated by the organic anion transporter 1 (OAT1) is a potential site of drug‐drug interactions. A number of marketed drugs inhibit OAT1, but the mechanism by which they do so is not typically known. The purpose was to investigate the predominant mechanism by which therapeutic drugs inhibit OAT1.
Ryan Pelis, Leslie Ingraham, Mansong Li
openaire   +1 more source

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning [PDF]

, 2020
The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), the main kidney elimination pathways for many common drugs, are often considered to have largely-redundant roles.
Nigam, Sanjay K, Nigam, Anisha K, Bhatnagar, Vibha, Bush, Kevin T, Lall, Kaustubh, Li, Julia G, Shi, Da, Abagyan, Ruben   +7 more
core   +1 more source

Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions

Scientific Reports, 2022
In vitro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6, NKT) and OAT3 (SLC22A8) among the main multi-specific “drug” transporters.
Neema Jamshidi, Sanjay K. Nigam
doaj   +1 more source

Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions

Journal of Xenobiotics, 2023
Accurate predictions of drug uptake transporter involvement in renal excretion of xenobiotics require determination of in vitro transport kinetic parameters under initial-rate conditions. The purpose of the present study was to determine how changing the
Aaron O. Buaben, Ryan M. Pelis
doaj   +1 more source

Human OAT1, OAT3, OAT4 and OATP1A2 Facilitate the Renal Accumulation of Ochratoxin A. [PDF]

Pharmaceutics
Background/Objectives: Ochratoxin A (OTA) is a widespread foodborne mycotoxin linked to chronic kidney disease of unknown etiology. Despite evidence from animal models showing OTA accumulation in the kidney, the molecular mechanisms underlying its renal disposition in humans remain only partially understood. Here.
Mahadeo A, Tsang YP, Zheng AR, Arnzen S, Rodriguez AG, Warren MS, Gáborik Z, Kelly EJ.   +7 more
europepmc   +3 more sources

Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

Asian Journal of Pharmaceutical Sciences, 2020
This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of ...
Yanna Zhu, Xiaokui Huo, Changyuan Wang, Qiang Meng, Zhihao Liu, Huijun Sun, Aiping Tan, Xiaodong Ma, Jinyong Peng, Kexin Liu   +9 more
doaj   +1 more source

Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2 [PDF]

Acta Pharmacologica Sinica, 2019
Rheumatoid arthritis patients can be prescribed a combination of immunosuppressive drug leflunomide (LEF) and the antiviral drug acyclovir to reduce the high risk of infection. Acyclovir is a substrate of organic anion transporter (OAT) 1/3 and multidrug resistance-associated protein (MRP) 2.
Liao, Xiao-ying, Deng, Qiang-qiang, Han, Li, Wu, Zhi-tao, Peng, Zhao-liang, Xie, Yuan, Wang, Guang-ji, Aa, Ji-ye, Pan, Guo-yu   +8 more
openaire   +2 more sources

Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9 [PDF]

Frontiers in Pharmacology, 2018
Ganoderma applanatum (G. applanatum) dispels wind to eliminate dampness and exhibited nephron- and liver-protective effects as noted in Chinese herbal classic literature; it might also affect hyperuricemia. Therefore, we examined the hypouricemia effects and mechanisms underlying G. applanatum on chemical-induced hyperuricemia in mice.
Tianqiao Yong, Tianqiao Yong, Shaodan Chen, Shaodan Chen, Yizhen Xie, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Chunwei Jiao, Dan Zuo   +10 more
openaire   +3 more sources

Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)

, 2016
Untargeted metabolomics on the plasma and urine from wild-type and organic anion transporter-1 (Oat1/Slc22a6) knockout mice identified a number of physiologically important metabolites, including several not previously linked to Oat1-mediated transport ...
Valentina L. Kouznetsova (1954795), William R. Wikoff (152177), Sanjay K. Nigam (315938), Igor F. Tsigelny (270708), Megha A. Nagle (2195140)   +4 more
core   +2 more sources

Expression of OAT1 and OAT3 in differentiating proximal tubules of the mouse kidney.

Histology and histopathology, 2009
Organic anion transporter 1 (OAT1) and OAT3 in the proximal tubules (PT) of the kidney play important roles in the elimination of harmful endogenous compounds and xenobiotics from the body. We investigated the temporal and spatial expression of OAT1 and OAT3 in the differentiating PT in mouse kidney.
Hwang, Jin-Sun, Park, Eun-Young, Kim, W.J., Yang, Chul-Woo, Kim, Jin   +4 more
openaire   +3 more sources