Results 21 to 30 of about 4,120 (207)

CO-EXPRESSION OF GCDH AND OAT1 IN NEURONS AND PROXIMAL TUBULE CELLS

, 2011
Tissue-specific expression studies of Glutaryl-CoA dehydrogenase (Gcdh) in adult rats revealed expression in the whole rat brain, almost exclusively in neurons, and surprisingly high expression in the juxtamedullar cortex of the kidney. The organic anion transporter 1 (OAT1) mediates basolateral uptake of glutarate derivatives from proximal tubule ...
Ballhausen, D., Jafari, P., Bonafe, L., Braissant, O.   +3 more
openaire   +2 more sources

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study. [PDF]

Clin Pharmacol Ther
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Thakur A, Unadkat JD, Fay EE, Isoherranen N, Hebert MF.   +4 more
europepmc   +2 more sources

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3 [PDF]

, 2021
Human OAT1 and OAT3 play major roles in renal drug elimination and drug-drug interactions. However, there is little information on the interactions of drug metabolites with transporters. The goal of this study was to characterize the interactions of drug
Zur, A. A., Zur, Arik A, Giacomini, Kathleen M, Ngo, H. X., Matsson, Pär,, Stecula, Adrian, Zou, L., Zou, Ling, Matsson, Pär, Ngo, Huy X, Giacomini, K. M., Stecula, A., Kathleen M. Giacomini, Pär Matsson, Huy X. Ngo, Adrian Stecula, Ling Zou, Arik A. Zur   +17 more
core   +1 more source

Serine encodes drug selectivity in human OAT1. [PDF]

Structure
Why do certain drugs bind human OAT1 with much higher affinity than the rat ortholog? In this issue of Structure, Jeon et al.1 reveal that serine 203, which is present only in human OAT1, coordinates with a chloride ion and this S203-chloride interaction is crucial for the high-affinity binding of olmesartan and other drugs.
Dai Y, Lee CH.
europepmc   +3 more sources

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity [PDF]

Clinical and Translational Science, 2017
AbstractCisplatin is among the most widely used anticancer drugs and known to cause a dose‐limiting nephrotoxicity, which is partially dependent on the renal uptake carrier OCT2. We here report a previously unrecognized, OCT2‐independent pathway of cisplatin‐induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3.
Hu, S, Leblanc, AF, Gibson, AA, Hong, KW, Kim, JY, Janke, LJ, Li, L, Vasilyeva, A, Finkelstein, DB, Sprowl, JA, Sweet, DH, Schlatter, E, Ciarimboli, G, Schellens, JHM, Baker, SD, Pabla, N, Sparreboom, A   +16 more
openaire   +2 more sources

Role of Glycosylation in the Organic Anion Transporter OAT1 [PDF]

Journal of Biological Chemistry, 2004
Organic anion transporters (OAT) play essential roles in the body disposition of clinically important anionic drugs, including antiviral drugs, antitumor drugs, antibiotics, antihypertensives, and anti-inflammatories. We reported previously (Kuze, K., Graves, P., Leahy, A., Wilson, P., Stuhlmann, H., and You, G. (1999) J. Biol. Chem.
Kunihiko, Tanaka, Wen, Xu, Fanfan, Zhou, Guofeng, You   +3 more
openaire   +2 more sources

Deletion of the Organic Anion Transporter OAT1 leads to Functional Changes in the Gut Microbiome [PDF]

, 2023
The Remote Sensing and Signaling Theory predicts inter-organ and inter-organismal small-molecule communication mediated by a network of “drug” transporters.
Ermakov, Vladimir
core   +1 more source

A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Frontiers in Pharmacology, 2022
Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors that are involved in diverse signaling pathways, influencing kidney fibrosis.
Yi Yang, Milos Mihajlovic, Floris Valentijn, Tri Q. Nguyen, Roel Goldschmeding, Rosalinde Masereeuw   +5 more
doaj   +1 more source

Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid

Pharmaceutics, 2021
We investigated the involvement of drug transporters in the pharmacokinetics of rosmarinic acid in rats as well as the transporter-mediated drug interaction potential of rosmarinic acid in HEK293 cells overexpressing clinically important solute carrier ...
Yun Ju Kang, Chul Haeng Lee, Soo-Jin Park, Hye Suk Lee, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3 [PDF]

, 2016
One of the characteristics of chronic kidney disease (CKD) is the accumulation of uremic solutes in the plasma. Less is known about the effects of uremic solutes on transporters that may play critical roles in pharmacokinetics. We evaluated the effect of
Zhao, Ping, Meyer, Timothy W, Ping Zhao (47228), Lei Zhang (38117), Huang, Shiew-Mei, Chia-Hsiang Hsueh (2925417), Shiew-Mei Huang (2925420), Kenta Yoshida (2050486), Zhang, Lei, Kathleen M. Giacomini (259990), Giacomini, Kathleen M, Timothy W. Meyer (2925414), Yoshida, Kenta, Hsueh, Chia-Hsiang   +13 more
core   +1 more source