Results 51 to 60 of about 5,258 (215)
PharmaceuticsOrganic anion transporter 3 (OAT3), expressed at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous metabolites, environmental toxins, and clinically important drugs.
Zhou Yu, Guofeng You
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Molecules, 2023 Bentysrepinine (Y101) is a novel phenylalanine dipeptide for the treatment of hepatitis B virus. Renal excretion played an important role in the elimination of Y101 and its metabolites, M8 and M9, in healthy Chinese subjects, although the molecular ...
Aijie Zhang +13 more
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Amelioration of mercury nephrotoxicity after pharmacological manipulation of organic anion transporter 1 (Oat1) and multidrug associated resistance protein 2 (Mrp2) with furosemide [PDF]
, 2015 Inorganic mercury is a major environmental contaminant. The primary site of mercuryinduced injury is the kidney due to the uptake of Hg(2+) -conjugated organic anions in the proximal tubule, primary across the organic anion transporter 1 (Oat1) at the ...
Chevalier, Alberto A. +4 more
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Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin [PDF]
American Journal of Physiology-Renal Physiology, 2018 The sodium-glucose cotransporter SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here we determined whether empagliflozin is secreted by renal tubules in mice and whether genetic knockout of the basolateral organic anion ...
Yiling Fu +13 more
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Clinical and Translational Science, 2021 Tolvaptan (TLV) was US Food and Drug Administration (FDA)‐approved for the indication to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease in 2018.
Susan E. Shoaf +2 more
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ATP/ADP biosensor organoids for drug nephrotoxicity assessment
Frontiers in Cell and Developmental Biology, 2023 Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal ...
Koichiro Susa +30 more
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Ivosidenib is a potent, targeted, orally active, small‐molecule inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) that has been approved in the United States for the treatment of adults with newly diagnosed acute myeloid leukemia (AML) who are ...
Jayaprakasam Bolleddula +3 more
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Frontiers in Pharmacology, 2023 Hesperetin is a natural flavonoid with many biological activities. In view of hyperuricemia treatment, the effects of hesperetin in vivo and in vitro, and the underlying mechanisms, were explored.
Meng-Fei An +21 more
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Organic Anion Transporter 5 (Oat5) Urinary Excretion Is a Specific Biomarker of Kidney Injury: Evaluation of Urinary Excretion of Exosomal Oat5 after N-Acetylcysteine Prevention of Cisplatin Induced Nephrotoxicity [PDF]
, 2015 Cisplatin is a commonly used chemotherapeutic agent. Its main side-effect is nephrotoxicity. It was reported that the organic anion transporter 5 (Oat5) urinary excretion is elevated, implying renal perturbation, when no modifications of traditional ...
Adriana Mónica Torres +11 more
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Immunolocalization of Multispecific Organic Anion Transporters, OAT1, OAT2, and OAT3, in Rat Kidney [PDF]
Journal of the American Society of Nephrology, 2002 Recently, a family of multispecific organic anion transporters has been identified, and several isoforms have been reported. However, the physiologic and pharmacologic roles of each isoform, except OAT1, in the transepithelial transport of organic anions in the kidney remain to be elucidated.
Ryoji, Kojima +5 more
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