Results 51 to 60 of about 3,886 (197)

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

Clinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang, Jashvant D Unadkat, Samuel LM Arnold, John K Fallon, Pouria Fattahi, Dan Dongeun Huh, Nicholas Ieronimakis, Edward J Kelly, Svetlana Lutsenko, Robert M Stroud, Jacqueline B Tiley, Jia Yang, Xujia Zhou, Hao Zhu, Rajini Rao, Kathleen M Giacomini, Lauren M Aleksunes   +16 more
wiley   +1 more source

Activation of Protein Kinase Cζ Increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated Transport

, 2009
Organic anion transporters (OATs) play a pivotal role in the clearance of small organic anions by the kidney, yet little is known about how their activity is regulated.
Srimaroeng, Chutima, Pritchard, John B., Perry, Jennifer L., Walden, Ramsey, Sweet, Douglas H., Dembla-Rajpal, Neetu, Barros, Scott   +6 more
core   +1 more source

A role for the organic anion transporter OAT3 in renal creatinine secretion in mice

American Journal of Physiology-Renal Physiology, 2012
Tubular secretion of the organic cation, creatinine, limits its value as a marker of glomerular filtration rate (GFR) but the molecular determinants of this pathway are unclear. The organic anion transporters, OAT1 and OAT3, are expressed on the basolateral membrane of the proximal tubule and transport organic anions but also neutral compounds and ...
Volker, Vallon, Satish A, Eraly, Satish Ramachandra, Rao, Maria, Gerasimova, Michael, Rose, Megha, Nagle, Naohiko, Anzai, Travis, Smith, Kumar, Sharma, Sanjay K, Nigam, Timo, Rieg   +10 more
openaire   +3 more sources

Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort

Cells, 2022
The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body.
Jiří Vávra, Andrea Mančíková, Kateřina Pavelcová, Lenka Hasíková, Jana Bohatá, Blanka Stibůrková   +5 more
doaj   +1 more source

Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS)

, 2010
Recent investigations involving intact rabbit renal proximal tubules indicated that organic anion transporter 3 (OAT3) may be involved in the transport of 2,3-dimercapto-1-propanesulfonic acid (DMPS).
Ugele, Bernhard, Burckhardt, Gerhard, Wright, Stephen H., Bahn, Andrew, Roediger, Matthias, Gersdorff, Nikolaus, Zhang, X.   +6 more
core   +1 more source

Immunolocalization of Multispecific Organic Anion Transporters, OAT1, OAT2, and OAT3, in Rat Kidney [PDF]

Journal of the American Society of Nephrology, 2002
Recently, a family of multispecific organic anion transporters has been identified, and several isoforms have been reported. However, the physiologic and pharmacologic roles of each isoform, except OAT1, in the transepithelial transport of organic anions in the kidney remain to be elucidated.
Ryoji, Kojima, Takashi, Sekine, Masanao, Kawachi, Seok Ho, Cha, Yoshio, Suzuki, Hitoshi, Endou   +5 more
openaire   +2 more sources

CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion

Journal of Pharmacological Sciences, 2021
Paeoniflorin-6′-O-benzene sulfonate (CP-25) is a derivative of Paeoniflorin. We investigate beneficial effect of CP-25 on methotrexate (MTX) induced nephrotoxicity in rats.
Xiao Wei, Yijin Wu, Hao Tang, Bin Wang, Yong Wang, Wei Sun, James Asenso, Feng Xiao, Chun Wang   +8 more
doaj   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3

European Journal of Pharmaceutical Sciences, 2012
The purpose is to investigate whether the targets of drug-drug interactions (DDIs) between JBP485 and acyclovir are OAT1 and OAT3 in kidney. Plasma concentration and accumulative urinary excretion of acyclovir in vivo, uptake of acyclovir in kidney slices and uptake of acyclovir in human (h) OAT1/ hOAT3-human embryonic kidney (HEK) 293 cells in vitro ...
Jianghao, Ye, Qi, Liu, Changyuan, Wang, Qiang, Meng, Jinyong, Peng, Huijun, Sun, Taiichi, Kaku, Kexin, Liu   +7 more
openaire   +2 more sources

Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction [PDF]

Hepatology, 2006
Renal function in the course of obstructive jaundice has been the subject of great interest; however, little is known about the expression of renal organic anion transporters. The objective of this work was to study, in rats with acute extrahepatic cholestasis, the cortical renal expression of
Anabel, Brandoni, Silvina R, Villar, Juan C, Picena, Naohiko, Anzai, Hitoshi, Endou, Adriana M, Torres   +5 more
openaire   +2 more sources