Results 71 to 80 of about 5,258 (215)
Clinical Pharmacology &Therapeutics, EarlyView.Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2021 Paeoniflorin-6′-O-benzene sulfonate (CP-25) is a derivative of Paeoniflorin. We investigate beneficial effect of CP-25 on methotrexate (MTX) induced nephrotoxicity in rats.
Xiao Wei +8 more
doaj +1 more source
Effects of Maternal Low Protein Diet on Expression of Drug Transporters in the Blood-Brain Barrier of Adult Offspring [PDF]
, 2012 Adverse uterine environment, manifested as low birth weight (LBW), has been shown to predispose individuals to hypertension, diabetes, and obesity by mechanisms that are just beginning to be understood.
Hastings, Bonnie L.
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo +5 more
wiley +1 more source
OAT3-Mediated Extrusion of the 99mTc-ECD Metabolite in the Mouse Brain [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2014 After administration of the 99mTc complex with N, N'-1,2-ethylenediylbis-L-cysteine diethyl ester (99mTc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by organic anion transporter 3 (OAT3), which is highly expressed ...
Tatsuya, Kikuchi +8 more
openaire +2 more sources
Interactions of organophosphate flame retardants with human drug transporters
Ecotoxicology and Environmental Safety, 2023 Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible
Valentin Tastet +6 more
doaj +1 more source
Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics‐Based Biomarkers
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Interindividual variability in drug pharmacokinetics and susceptibility to drug–drug interactions remain major barriers in precision dosing, particularly for narrow therapeutic index drugs. While genetic factors contribute, much variability arises from dynamic influences such as physiology, disease, age, diet, microbiome, and concomitant ...
Bhagwat Prasad
wiley +1 more source
On the design and implementation of broadcast and global combine operations using the postal model [PDF]
, 1996 There are a number of models that were proposed in recent years for message passing parallel systems. Examples are the postal model and its generalization the LogP model. In the postal model a parameter λ is used to model the communication latency of the
Bruck, Jehoshua +4 more
core +1 more source