Results 91 to 100 of about 3,886 (197)

Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Renal clearance (CLr) is the net outcome of glomerular filtration, secretion, and reabsorption, which makes the quantitative requirements for net renal secretion difficult to infer from simple clearance models. Using a mechanistic kidney model (MechKiM), we simulated blood‐referenced CLr (CLr,b) for 30,000 virtual drugs (neutral, monoanionic ...
Toshiaki Tsuchitani, Masatoshi Tomi, Yuichi Sugiyama   +2 more
wiley   +1 more source

Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

, 2008
Carboxyfluoroquinolones, such as ciprofloxacin, are employed for numerous infectious diseases. Renal secretion is a major determinant of their systemic and urinary concentration, but the specific transporters involved are virtually unknown.
Srimaroeng, Chutima, C. Srimaroeng, A. L. VanWert, VanWert, Adam L., Sweet, Douglas H., D. H. Sweet   +5 more
core   +1 more source

Organic anion transporters and their influence on the toxicity of β-lactam antibiotics

Безопасность и риск фармакотерапии, 2018
This review article describes the classification and mechanism of action of organic anion transporters (OAT). The influence of certain members of this family of transporters on the pharmacokinetics of β-lactam antibiotics.
V. A. Evteev, O. V. Muslimova, I. A. Mazerkina, N. D. Bunyatyan, E. V. Shikh, R. E. Kazakov   +5 more
doaj  

Bempedoic Acid, the First-in-Class Oral ATP Citrate Lyase Inhibitor with Hypocholesterolemic Activity: Clinical Pharmacology and Drug–Drug Interactions

Pharmaceutics
Bempedoic acid is a new drug that improves the control of cholesterol levels, either as monotherapy or in combination with existing lipid-lowering therapies, and shows clinical efficacy in cardiovascular disease patients.
Nicola Ferri, Elisa Colombo, Alberto Corsini   +2 more
doaj   +1 more source

ROS, OAT3, AhR and NF-κB p65 are involved in IS-induced PRR expression in vascular smooth muscle cells.

, 2014
Serum-starved HASMCs were pretreated with NAC (2.5 mmol/L) and DPI (10 µmol/L) for 30 min before incubation with IS (250 µmol/L) for 24 h (A,B). HASMCs were transfected with or without OAT3 siRNA (10 nmol/L), AhR siRNA (30 nmol/L) or p65 siRNA (10 nmol/L)
Shaniya Abudureyimu (649239), Yelixiati Adelibieke (533238), Shinichi Saito (533237), Kyosuke Takeshita (505183), Hwee-Yeong Ng (533235), Toshimitsu Niwa (533239), Fuyuhiko Nishijima (315403), Toyoaki Murohara (155568), Maimaiti Yisireyili (533236)   +8 more
core   +1 more source

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Drug Design, Development and Therapy, 2015
Hyeon-Uk Jeong,1 Mihwa Kwon,2 Yongnam Lee,3 Ji Seok Yoo,3 Dae Hee Shin,3 Im-Sook Song,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences ...
Jeong HU, Kwon M, Lee Y, Yoo JS, Shin DH, Song IS, Lee HS   +6 more
doaj  

Expression and protein localization of Oat1, Oat3, Oct1, and Hnf4α in the proximal tubule.

, 2013
Evidence from existing literature validates the result of microarray analysis. The genes and protein products of Hnf4α, Oat1, Oat3, and Oct1 are present in the proximal tubule during organogenesis and adulthood.
Gleb Martovetsky (315935), Valentina Kouznetsova (315936), Thomas F. Gallegos (315933), Sanjay K. Nigam (315938), Kevin T. Bush (315937)   +4 more
core   +1 more source

Transport of Xanthurenic Acid by Rat/Human Organic Anion Transporters OAT1 and OAT3

Bioscience, Biotechnology, and Biochemistry, 2013
Kynurenic acid, a tryptophan metabolite, is involved in psychiatric disease. Our laboratory previously described its transport by rat/human organic anion transporters rOAT1, hOAT1, rOAT3 and hOAT3, which are involved in drug disposition. In this study, we performed an uptake experiment using Xenopus laevis oocytes to examine the transport of ...
UWAI, Yuichi, HONJO, Emi
openaire   +2 more sources

Impact of Organic Anion Transporter 3 (OAT3) on Bendamustine Uptake of Lymphoma Cells.

Blood, 2007
Abstract One main problem of tumor therapy is the resistance of malignant cells to cytostatics due to high expression of efflux transporters. Whereas the role of these efflux transporters for tumor cell resistance is well established, little is known about uptake transporters, which may increase the sensibility of tumor cells for ...
Hagos, Yohannes, Wulf, Gerald G., Shnitsar, Vladimir, Hundertmark, Philip, Gupta, Shvangi, Burckhardt, Gerhard   +5 more
openaire   +2 more sources

Interaction of Human Renal Organic Anion Transporter OAT1 and OAT3 with Flavonoids [PDF]

An antioxidant effect of the flavonoids in food has been widely noticed as it may prevent the oxidative stress-associated chronic diseases including ischemic heart disease and diabetes mellitus.
Ouchi, Motoshi, Ueda, Yoshihiko, Fujita, Tomoe, Abe, Tokuro, Otani, Naoyuki, Anzai, Naohiko, Morita, Asuka   +6 more
core   +1 more source