Results 111 to 120 of about 3,886 (197)

Sex-dependent expression of Oat1 and Oat3 in rat cortical kidney slices.

, 2012
Levels of β-actin, Hprt1, Oat1 and Oat3 were analyzed by TaqMan® real-time PCR in total RNA isolated from four male and four female cortical kidney slices.
Birgitta Christina Burckhardt (170394), Waja Wegner (170389), Maja Henjakovic (170401), Gerhard Burckhardt (170397)   +3 more
core   +1 more source

Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats

Metabolites
Chaenomeles speciosa (Sweet) Nakai (C. speciosa) fruit has medicinal and food applications and exhibits beneficial pharmacological properties. This study aimed to explore the hypouricemic effect of C.
Ruoling Xu, Peng Deng, Yiren Ma, Kui Li, Fucai Ren, Ning Li   +5 more
doaj   +1 more source

Exploration of leech therapy in treating gouty rats and its uric acid lowering mechanism

Journal of Ayurveda and Integrative Medicine
Background: Gout is a hyperuricemia (HUA)-related inflammatory reaction in the joints. Leech therapy has been effective in the gout, but the exact mechanism is unclear.
Gao Ling chao, Li Xiang shen, Pan Li, Peng Xiao hua, Mo Ling ling, Zhou Yuan yuan, Chen Chuang   +6 more
doaj   +1 more source

In vitro and in silico characterization of the transport of selected perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonic acids by human organic anion transporter 1 (OAT1), OAT2 and OAT3

: Perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkyl sulfonic acids (PFSAs) belong to the group of poly- and perfluoroalkyl substances (PFASs), which may accumulate in humans due to their limited excretion. To provide more insight into the active
Punt, Ans, Koenderink, Jan B., Leenders, Liz, Russel, Frans G. M., Rijkers, Deborah, Noorlander, Annelies, Dellafiora, Luca, Louisse, Jochem, van den Heuvel, Jeroen J. M. W., Pedroni, Lorenzo, Koenderink, J.B., Russel, F.G.M., Louisse, J., Pedroni, L., Noorlander, A., Leenders, L., Punt, A., Dellafiora, L., Heuvel, J.J.M.W. van den, Rijkers, D.   +19 more
core   +1 more source

Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling

CPT: Pharmacometrics & Systems Pharmacology
Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may incorporate RT activity, but this requires ...
J. Porter Hunt, Samuel Dubinsky, Autumn M. McKnite, Kit Wun Kathy Cheung, Bianca D. vanGroen, Kathleen M. Giacomini, Saskia N. deWildt, Andrea N. Edginton, Kevin M. Watt   +8 more
doaj   +1 more source

Expression of OAT1 and OAT3 in differentiating proximal tubules of the mouse kidney [PDF]

, 2010
Organic anion transporter 1 (OAT1) and OAT3 in the proximal tubules (PT) of the kidney play important roles in the elimination of harmful endogenous compounds and xenobiotics from the body. We investigated the temporal and spatial expression of OAT1
Kim, W.J., Park, Eun-Young, Yang, Chul-Woo, Kim, Jin, Hwang, Jin-Sun   +4 more
core  

OAT3-mediated extrusion of the (99m)Tc-ECD metabolite in the mouse brain.

After administration of the (99m)Tc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester ((99m)Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat.
福村 利光, 脇坂 秀克, Okada, Maki, 466248, 由井 譲二, 466249, 466246, 466247, B, Tsuji Atsushi, 466255, 466256, 466253, 466254, Zhang, Ming-Rong, 466251, 466252, 張 明栄, 466250, Yui, Joji, Kikuchi, Tatsuya, 菊池 達矢, 小高 謙一, Wakizaka, Hidekatsu, 466259, 466257, 466258, 466244, 466245, 466243, 岡村 敏充, 466260, Odaka, Kenichi, Okamura, Toshimitsu, Fukumura, Toshimitsu, 岡田 真希, 辻 厚至   +35 more
core  

Dose Optimization of Cefazolin for Pediatric Patients with Renal Impairment Using Physiologically Based Pharmacokinetic Modeling (PBPK) in GastroPlus. [PDF]

Pharmaceutics
Abdeen A, Bin Jardan YA, Rahim N, Alshami R, Löbenberg R, Sarfraz M.   +5 more
europepmc   +1 more source

Transporter Interactions of Methoxyflavones and Their <i>In Vivo</i> Pharmacokinetic Implications. [PDF]

ACS Omega
Kang MJ, Lee KR, Song H, Seol Y, Chae YJ.   +4 more
europepmc   +1 more source

Flavonoid Interactions with Renal Organic Anion Transporters OAT1 and OAT3: Structure-Activity Relationships and Clinical Implications. [PDF]

Int J Mol Sci
Tong K, Ye P, Kaneda-Nakashima K, Zhang H, Wei L.   +4 more
europepmc   +1 more source