Results 121 to 130 of about 5,258 (215)

Expression of organic anion transporter Oat3 in rat liver is gender-dependent

Periodicum biologorum, 2007
In the mammalian liver, elimination of endogenous and exogenous organic anions (metabolic products, various drugs, environmental toxins) is mediated by various organic anion transporters (OATs), transmembrane proteins that belong to solute carrier family Slc22. The rat liver organic anion transporter 3 (rOat3, Slc22a8) has been cloned, characterized as
Breljak, Davorka, Ljubojević, Marija, Balen, Daniela, Žlender, Vilim, Anzai, Naohiko, Burckhardt, Gerhard, Sabolic, Ivan   +6 more
openaire   +2 more sources

Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling

CPT: Pharmacometrics & Systems Pharmacology
Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may incorporate RT activity, but this requires ...
J. Porter Hunt, Samuel Dubinsky, Autumn M. McKnite, Kit Wun Kathy Cheung, Bianca D. vanGroen, Kathleen M. Giacomini, Saskia N. deWildt, Andrea N. Edginton, Kevin M. Watt   +8 more
doaj   +1 more source

Effects of reaction control system jet simulation on the stability and control characteristics of a 0.015-scale space shuttle orbiter model in the Ames Research Center 3.5-foot hypersonic wind tunnel [PDF]

An experimental investigation was performed in the Ames Research Center 3.5-Foot Hypersonic Wind Tunnel to obtain detailed effects which interactions between the RCS jet flow field and the local orbiter flow field have on orbiter hypersonic stability and
Cleary, J. W., Dziubala, T. J., Marroquin, J., Mellenthin, J. A.   +3 more
core   +1 more source

Flavonoid Interactions with Renal Organic Anion Transporters OAT1 and OAT3: Structure-Activity Relationships and Clinical Implications. [PDF]

Int J Mol Sci
Tong K, Ye P, Kaneda-Nakashima K, Zhang H, Wei L.   +4 more
europepmc   +1 more source

Dual mechanisms of a purified root extract of <i>Paeonia lactiflora</i> Pall. in regulating uric acid homeostasis: inhibition of hepatic synthesis and promotion of renal excretion in hyperuricemic rat models. [PDF]

Front Pharmacol
Jin T, Xu R, Jiang Z, Ma J, Li N.
europepmc   +1 more source

A Novel Dual URAT1/GLUT9 Inhibitor Reduces Hyperuricemia by Enhancing Uric Acid Excretion and Attenuating Renal Fibrosis. [PDF]

Pharmaceuticals (Basel)
Zhang H, Huang J, Yang W, Zhou W, Ding J, Li Q, Hu G.   +6 more
europepmc   +1 more source

Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model [PDF]

, 2014

core   +1 more source

Human OAT1, OAT3, OAT4 and OATP1A2 Facilitate the Renal Accumulation of Ochratoxin A. [PDF]

Pharmaceutics
Mahadeo A, Tsang YP, Zheng AR, Arnzen S, Rodriguez AG, Warren MS, Gáborik Z, Kelly EJ.   +7 more
europepmc   +1 more source

Renoprotective effects of perennial ryegrass attenuate UA mediated renal damage via modulating gut microbiota and anti-oxidative defense. [PDF]

Poult Sci
Asif MA, Zulfiqar Z, Zhang KJ, Mustafa BE, Asif MI, Saif S, Cui Y, Boshuai L, Shi Y.   +8 more
europepmc   +1 more source

Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3-O-Sulfate (GCDCA-S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters. [PDF]

Clin Pharmacol Ther
Ujihira Y, Georgiev V, Ogungbenro K, Galetin A.   +3 more
europepmc   +1 more source