Results 101 to 110 of about 3,886 (197)

Effect of diabetes on Oat3 expression in the renal cortex.

, 2014
(A) and (C); Western blot analysis for Oat3 in the membrane and whole cell lysate fractions of renal cortical tissues in control, diabetic (DM) and diabetic with insulin-treated (DM-treated) rats, respectively.
Phatchawan Arjinajarn (560383), Chutima Srimaroeng (560385), Lisa Chatsudthipong (388058), Anchalee Pongchaidecha (560384), Anusorn Lungkaphin (560382), Varanuj Chatsudthipong (388060)   +5 more
core   +1 more source

Alterations in gene expression in vitamin D-deficiency:Down regulation of liver Cyp7a1 and renal Oat3 in mice [PDF]

, 2018
The vitamin D-deficient model, established in the C57BL/6 mouse after 8 weeks of feeding vitamin D-deficient diets in the absence or presence of added calcium, was found associated with elevated levels of plasma parathyroid hormone (PTH) and plasma and ...
Edwin C.Y. Chow, Hoi, Stacie Y., Bruinsma, Adriaan, K. Sandy Pang, Keumhan Noh, Geny M.M. Groothuis, Quach, H.P., Li, Albert P., Holly P. Quach, Albert P. Li, Noh, Keumhan, Groothuis, Genoveva, Stacie Y. Hoi, Adrie Bruinsma, Pang, K. Sandy, Chow, Edwin C.Y.   +15 more
core   +1 more source

The contribution of Organic Anion Transporters OAT1 and OAT3 to the renal uptake of rosuvastatin

Rosuvastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase and has been shown to be highly effective in reducing low-density lipoprotein cholesterol.
Lowes S, Windass A, Wang Y, Brown C
core   +4 more sources

Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.

PLoS ONE, 2014
UnlabelledChronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD). (Pro)renin receptor (PRR) is activated in the kidney of CKD.
Maimaiti Yisireyili, Shinichi Saito, Shaniya Abudureyimu, Yelixiati Adelibieke, Hwee-Yeong Ng, Fuyuhiko Nishijima, Kyosuke Takeshita, Toyoaki Murohara, Toshimitsu Niwa   +8 more
doaj   +1 more source

ROS, OAT3, AhR, and NF-κB p65 are involved in IS-induced prorenin expression in vascular smooth muscle cells.

, 2014
Serum starved HASMCs were pretreated with NAC (2.5 mmol/L) and DPI (10 µmol/L) for 30 min before incubation with IS (250 µmol/L) for 24 h (A, B). HASMCs were transfected with or without OAT3 siRNA (10 nmol/L), AhR siRNA (30 nmol/L) or p65 siRNA (10 nmol ...
Shaniya Abudureyimu (649239), Yelixiati Adelibieke (533238), Shinichi Saito (533237), Kyosuke Takeshita (505183), Hwee-Yeong Ng (533235), Toshimitsu Niwa (533239), Fuyuhiko Nishijima (315403), Toyoaki Murohara (155568), Maimaiti Yisireyili (533236)   +8 more
core   +1 more source

Effect of uptake transporters OAT3 and OATP1B1 and efflux transporter MRP2 on the pharmacokinetics of eluxadoline

The Journal of Clinical Pharmacology, 2015
AbstractThe effects of OATP1B1, OAT3, and MRP2 on the pharmacokinetics of eluxadoline, an oral, locally active, opioid receptor agonist/antagonist being developed for treatment of IBS‐d were assessed in vivo. Coadministration of a single 200 mg dose of eluxadoline with cyclosporine, and probenecid increased eluxadoline systemic exposure [AUC(0–inf)] by
Davenport, J Michael, Covington, Paul, Bonifacio, Laura, McIntyre, Gail, Venitz, Jürgen   +4 more
openaire   +2 more sources

Bezafibrate–mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats

European Journal of Pharmaceutical Sciences, 2016
A patient with rheumatoid arthritis developed rhabdomyolysis while undergoing treatment with mizoribine concomitantly with bezafibrate. The symptoms rapidly disappeared and laboratory test results normalized when she discontinued the two drugs. The purpose of the present study was to elucidate the transporter-mediated molecular pharmacokinetic ...
Yuan Feng, Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Zhihao Liu, Pengyuan Sun, Xiaobo Yang, Huijun Sun, Jianhua Qin, Kexin Liu   +10 more
openaire   +2 more sources

Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions

CPT: Pharmacometrics & Systems Pharmacology
Pyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur, Sumathy Mathialagan, Emi Kimoto, Manthena V. S. Varma   +3 more
doaj   +1 more source

Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3)

, 2016
Dantrolene is the only available drug for the treatment of malignant hyperthermia, a life-threatening inborn sensitivity of the ryanodine receptor (RyR1) in skeletal muscles to volatile anesthetics.
Burckhardt, Gerhard, Burckhardt, Birgitta-Christina, Hagos, Yohannes, Henjakovic, Maja   +3 more
core   +1 more source

Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition

, 2004
In rats, the secretion of p-aminohippurate (PAH) by the kidney is higher in males ( M) than in females ( F). The role of the major renal PAH transporters, OAT1 and OAT3, in the generation of these gender differences, as well as the responsible hormones ...
Burckhardt, Gerhard, Bahn, A., Sabolic, Ivan, Hagos, Yohannes, Ljubojevic, M., Endou, H., Herak-Kramberger, C. M.   +6 more
core   +1 more source