Results 81 to 90 of about 5,258 (215)
Impact of Organic Anion Transporter 3 (OAT3) on Bendamustine Uptake of Lymphoma Cells.
Blood, 2007 Abstract One main problem of tumor therapy is the resistance of malignant cells to cytostatics due to high expression of efflux transporters. Whereas the role of these efflux transporters for tumor cell resistance is well established, little is known about uptake transporters, which may increase the sensibility of tumor cells for ...
Hagos, Yohannes +5 more
openaire +2 more sources
CPT: Pharmacometrics & Systems Pharmacology, 2020 Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion ...
Stephanie N. Liu +2 more
doaj +1 more source
Uraemic toxins and new methods to control their accumulation : game changers for the concept of dialysis adequacy [PDF]
, 2015 The current concept of an adequate dialysis based only on the dialysis process itself is rather limited. We now have considerable knowledge of uraemic toxicity and improved tools for limiting uraemic toxin accumulation. It is time to make use of these. A
Glorieux, Griet, Tattersall, James
core +2 more sources
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 7, Page 945-954, April 2026.Current first‐line NUCs show comparable renal safety profiles in CHB patients with no or mild kidney dysfunction, with growing evidence that favours TAF. Future prospective studies are needed to validate these findings, and more research should focus on CHB patients with diabetes mellitus who are at risk of CKD.
Lung‐Yi Mak +2 more
wiley +1 more source
Scientific Reports, 2017 In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two “drug” transporters of the organic anion transporter (OAT) family:
Wei Wu, Kevin T. Bush, Sanjay K. Nigam
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar +2 more
wiley +1 more source
Journal of Traditional Chinese Medical Sciences, 2019 Objective: Hyperuricemia is an excess of urate in blood. The kidneys play important parts in urate excretion, which involves handling reabsorption and secretion.
Yu Wang +4 more
doaj +1 more source
Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice
Antioxidants, 2023 High uric acid is associated with gout, hypertension, metabolic syndrome, cardiovascular disease, and kidney disease. URAT1 (SLC22A12), originally discovered in mice as Rst, is generally considered a very selective uric acid transporter compared to other
Neema Jamshidi +2 more
doaj +1 more source
In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters
The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou +9 more
wiley +1 more source
BMC Complementary and Alternative Medicine, 2019 Background Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhibit anti-hyperuricemic and ...
Seung Hoon Lee +4 more
doaj +1 more source