Results 81 to 90 of about 3,886 (197)

Real‐World Claims Data on Prescribed Drugs and the Associated Drug–Drug Interaction Risk in Sickle Cell Disease in the United States

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
Real‐world prescription data from 6230 adolescents and adults living with sickle cell disease (SCD) were combined with a drug–drug interaction (DDI) database to characterize the population‐level DDI risk. The findings support a DDI risk assessment for development of novel SCD therapies and during clinical management of SCD.ABSTRACTSickle cell disease ...
Rune Aabjerg Nørgaard, Laura Grenier, Peter Bruun‐Rasmussen, Ifeyinwa Osunkwo, Carolina Säll   +4 more
wiley   +1 more source

A hypothetical model for the regulation of renal Oat3 in diabetic condition.

, 2014
Insulin regulates Oat3 function by activating PKCζ and PKB through PI3K leading to up-regulation of Oat3 function and increased trafficking of Oat3 to plasma membrane and subsequently increased transport function.
Phatchawan Arjinajarn (560383), Chutima Srimaroeng (560385), Lisa Chatsudthipong (388058), Anchalee Pongchaidecha (560384), Anusorn Lungkaphin (560382), Varanuj Chatsudthipong (388060)   +5 more
core   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju, HeeJae Choi, Shilpa Madari, Annie Carlisle, Ashish Sharma, Christina Kunz, Fenglei Huang   +6 more
wiley   +1 more source

Distribution of the organic anion transporters Oat1 and Oat3 between renal membrane microdomains in obstructive jaundice

, 2020
Relation between the renal function and the membrane environment where the organic anion transporters Oat1 and Oat3 are localized is scarce. The aim of this study was to examine the Oat1 and Oat3 distribution in different cellular fractions under ...
Nosetto, Evangelina Cecilia, Torres, Adriana Mónica, Brandoni, Anabel, Campagno, Romina Valeria   +3 more
core   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate

Cellular Physiology and Biochemistry, 2015
Background/Aims: Hyperuricemia is an independent risk factor for chronic kidney disease and cardiovascular disease. Here, we examined the combined protective effects of Chinese herbal formula Si-Wu-Tang and Er-Miao-San on hyperuricemia and renal ...
Yongping Guo, Qian Jiang, Dingkun Gui, Niansong Wang   +3 more
doaj   +1 more source

Metabolomic Profiling Delineates Stage‐Associated Metabolic Remodelling in Cardiovascular‐Kidney‐Metabolic Syndrome

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
Using widely targeted metabolomics, we profiled 1374 participants across CKM stages 0–4 and identified 261 metabolites exhibiting distinct, non‐linear patterns of remodelling in lipid, carbohydrate, amino acid, and redox/energy metabolism. WGCNA further identified a 148‐metabolite turquoise module associated with CKM stage, with γ‐glutamylvaline ...
Xuemei Gong, Chunyang Li, Jing Chen, Yujiao Wang, Wenge Tang, Xuehui Zhang, Jianzhong Yin, Xing Zhao, Haopeng Yu, Ping Fu, Xiaoxi Zeng   +10 more
wiley   +1 more source

Alignment of Micrometer‐Scale Electrospun Fibers Does Not Enhance Performance of Primary Human Renal Proximal Tubular Epithelial Cells

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 9, September 2026.
ABSTRACT Renal failure remains a leading cause of morbidity and mortality, as current renal replacement therapies restore filtration but fail to replicate the kidney's transport, metabolic, and endocrine functions. Bioengineered systems using primary renal epithelial cells show promise in recapitulating these processes, and integration into synthetic ...
IJsbrand M. Vermue, Christian G. M. van Dijk, Ihsan Chrifi, Ymke Appels, Jurjen van Meijeren, Bastiaan Terhaard, Nahid Kasaiyan, Marianne C. Verhaar, Caroline Cheng   +8 more
wiley   +1 more source

Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes

Pharmaceuticals
Background/Objectives: Pinocembrin is a promising drug candidate for treating ischemic stroke. The interaction of pinocembrin with drug transporters and drug-metabolizing enzymes is not fully revealed.
Sirima Sangkapat, Rattiporn Boonnop, Jeerawat Pimta, Napason Chabang, Bodee Nutho, Promsuk Jutabha, Sunhapas Soodvilai   +6 more
doaj   +1 more source

Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics and the Pharmacokinetics of Balcinrenone When Dosed with a P‐gp Inhibitor

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Balcinrenone (AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist with a distinct mode of action being developed as a fixed‐dose combination with the sodium–glucose cotransporter‐2 inhibitor dapagliflozin for the treatment of heart failure with impaired kidney function, and chronic kidney disease.
Anna L. Eriksson, Deeyen Karsanji, Amy H. Shi, Joanna Parkinson, Maria Heijer, Edward Austin, Bosse Lindmark, Charlotta Vedin‐Nilsson, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +10 more
wiley   +1 more source