Results 61 to 70 of about 5,258 (215)

Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)

Bioengineering, 2023
The kidney proximal tubule (PT) mediates renal drug elimination in vivo and is a major site of drug-induced toxicity. To reliably assess drug efficacy, it is crucial to construct a model in which PT functions are replicated.
Francesca Pisapia, Donovan O’Brien, Elena Tasinato, Kathryn L. Garner, Colin D. A. Brown   +4 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

OAT1 and OAT3: Targets of drug–drug interaction between entecavir and JBP485

European Journal of Pharmaceutical Sciences, 2013
Entecavir and JBP485 (a dipeptide) exhibit the antihepatitis activities and it is possible for the two drugs to be coadministered in the treatment of hepatitis. We aimed to elucidate whether entecavir was a substrate of OAT1, OAT3, OCT, and PEPT1 and to investigate the targets of drug-drug interactions between entecavir and JBP485.
Qinghan, Xu, Changyuan, Wang, Qiang, Meng, Qi, Liu, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Taiichi, Kaku, Kexin, Liu   +8 more
openaire   +2 more sources

Activation of Protein Kinase Cζ Increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated Transport [PDF]

Journal of Biological Chemistry, 2009
Organic anion transporters (OATs) play a pivotal role in the clearance of small organic anions by the kidney, yet little is known about how their activity is regulated. A yeast two-hybrid assay was used to identify putative OAT3-associated proteins in the kidney. Atypical protein kinase Czeta (PKCzeta) was shown to bind to OAT3.
Barros, Scott, Srimaroeng, Chutima, Perry, Jennifer L., Walden, Ramsey, Dembla-Rajpal, Neetu, Sweet, Douglas H., Pritchard, John B.   +6 more
openaire   +3 more sources

Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. [PDF]

PLoS ONE, 2012
Proper physiological function in the pre- and post-natal proximal tubule of the kidney depends upon the acquisition of selective permeability, apical-basolateral epithelial polarity and the expression of key transporters, including those involved in ...
Thomas F Gallegos, Gleb Martovetsky, Valentina Kouznetsova, Kevin T Bush, Sanjay K Nigam   +4 more
doaj   +1 more source

The Impact of Inflammation on the In Vivo Activity of the Renal Transporters OAT1/3 in Pregnant Women Diagnosed with Acute Pyelonephritis

Pharmaceutics, 2023
Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact of inflammation on renal drug transporters remains to be elucidated.
Jhohann Richard de Lima Benzi, Patrícia Pereira dos Santos Melli, Geraldo Duarte, Jashvant D. Unadkat, Vera Lucia Lanchote   +4 more
doaj   +1 more source

Molecular Dynamics of Yukawa System using the Fast Multipole Method [PDF]

, 2001
In order to perform the large-scale molecular dynamics simulation of the Yukawa system, a mathematical expression for molecular dynamics using the fast multipole method is described. The model simulations are also performed to test the performance of our
Kishimoto, Tokunari, Totsuji, Chieko, Totsuji, Hiroo, Tsuruta, Kenji   +3 more
core   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort

Cells, 2022
The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body.
Jiří Vávra, Andrea Mančíková, Kateřina Pavelcová, Lenka Hasíková, Jana Bohatá, Blanka Stibůrková   +5 more
doaj   +1 more source

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. [PDF]

, 2019
Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters,
Bush, Kevin T, Nigam, Sanjay K, Rosenthal, Sara Brin   +2 more
core   +1 more source