Results 41 to 50 of about 5,258 (215)

Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

Asian Journal of Pharmaceutical Sciences, 2020
This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of ...
Yanna Zhu, Xiaokui Huo, Changyuan Wang, Qiang Meng, Zhihao Liu, Huijun Sun, Aiping Tan, Xiaodong Ma, Jinyong Peng, Kexin Liu   +9 more
doaj   +1 more source

Competative inhibition of renal tubular secretion of gemifloxacin by probenecid [PDF]

, 2009
Probenecid interacts with transport processes of drugs at several sites in the body. For most quinolones, renal clearance is reduced by concomitant administration of probenecid. The interaction between gemifloxacin and probenecid has not yet been studied.
Landersdorfer, Cornelia B., Kirkpatrick, Carl M. J., Kinzig, Martina, Bulitta, Jurgen B., Holzgrabe, Ulrike, Drusano, George L., Sorgel, Fritz   +6 more
core   +1 more source

Analyses of 5′ regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3) [PDF]

Journal of Human Genetics, 2006
Kidney excretion of numerous organic anionic drugs and endogenous metabolites is carried out by a family of multispecific organic anion transporters (OATs). Two closely related transporters, SLC22A6, initially identified by us as NKT and also known as OAT1, and SLC22A8, also known as OAT3 and ROCT, are thought to mediate the initial steps in the ...
Vibha, Bhatnagar, Gang, Xu, Bruce A, Hamilton, David M, Truong, Satish A, Eraly, Wei, Wu, Sanjay K, Nigam   +6 more
openaire   +2 more sources

Current trends in drug metabolism and pharmacokinetics. [PDF]

, 2019
Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication.
Abduljalil, Aghazadeh-Habashi, Aigrain, Aitman, Al Za'abi, Alegre, Alnaqeeb, Aspromonte, Babiskin, Baert, Bakke, Barnett, Bhattacharyya, Cang, Cannady, Cao, Cao, Capecchi, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Cheng, Crawford, Currie, De Lange, Dean, Deng, Di Paolo, Dietrich, Diliberto, Dluzen, Dowling, Dragin, Dreisbach, Duan, Edeogu, Edginton, El-Arabey, El-Kadi, EMA, Eum, Falany, Fang, FDA, Feng, Feng, Feng, Ferri, Fleming, Foti, Fox, Freedman, Frye, Fukami, Gaj, Gan, Gao, Gao, Gao, Gao, Gao, Ge, Genovese, Gingell, Gingell, Gong, Graham, Gufford, Guo, Guo, Guo, Guévin, Han, Harrison, Hartz, Hasegawa, He, He, He, He, He, Ho, Ho, Hou, Hsu, Hsueh, Hu, Hu, Hu, Huo, Hwang, Ito, Jacob, Jeong, Jeong, Jia, Jian, Jiang, Jiang, Jiang, Jiang, Jilek, Jilek, Johnson, Jorga, Jung, Kaivosaari, Kalthoff, Kaminsky, Kannan, Karibe, Kesisoglou, Kim, Kim, Knights, Kong, Kota, Kumar, Kurokawa, Lai, Lan, Lanchote, Lee, Lehouritis, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Liang, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Lopes-Rodrigues, Lu, Lu, Lu, Löfgren, Mano, Marchitti, Margolskee, Martin, Matsson, Mattick, Mazerska, Mei, Mencia, Meng, Min, Mitra, Miyajima, Müller, Nair, Nakano, Nakano, Nakano, Nebert, Nguyen, Niederalt, Nieto Montesinos, Niu, Notenboom, Nozaki, Ohtsuki, Ono, Oostendorp, Pan, Pan, Papageorgiou, Papageorgiou, Park, Pea, Pedersen, Pelkonen, Pellegrino, Pettersson Bergstrand, Qi, Qin, Qiu, Qiu, Raaska, Rives, Riviere, Roberts, Robey, Rocha, Rose, Routy, Rowland, Ruwali, Saini, Satoh, Savage, Scheer, Scheer, Schlender, Schmitt, Schneider, Seitz, Showande, Shu, Shu, Shu, Shugarts, Siu, Song, Staudinger, Strong, Suarez-Sharp, Suh, Suiko, Sukkummee, Sun, Sun, Sutliff, Takeda, Tan, Tan, Tao, Tatsumi, Teorell, Tsai, Tsang, Tsuchiya, Tsume, Tu, Ulldemolins, van Waterschoot, von Richter, Vugmeyster, Vuppugalla, Wagner, Wagner, Wagner, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wassenaar, Watanabe, Wei, Wijayakumara, Wilkinson, Wong, Wu, Xia, Xie, Xie, Xu, Xu, Xu, Xu, Xu, Xue, Yamagata, Yamaguchi, Yan, Yang, Yang, Yang, Ye, Yellepeddi, Yi, Yi, Yigitaslan, Yim, Yin, Yoshida, Yoshida, Yoshimi, Yu, Yu, Yu, Yu, Yu, Yu, Yu, Zakeri-Milani, Zanger, Zeng, Zeng, Zhai, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhao, Zhou, Zhou, Zhou, Zhou, Zhou, Zhu, Zhu, Zhu, Zhuang, Zimmermann   +332 more
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The importance of steroid uptake and intracrine action in endometrial and ovarian cancers [PDF]

, 2017
Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Laczka, Csilla, Rižner, T. L., Thalhammer, T.   +2 more
core   +4 more sources

Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions

Scientific Reports, 2022
In vitro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6, NKT) and OAT3 (SLC22A8) among the main multi-specific “drug” transporters.
Neema Jamshidi, Sanjay K. Nigam
doaj   +1 more source

Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition. [PDF]

, 2016
The circadian clock controls a wide variety of metabolic and homeostatic processes in a number of tissues, including the kidney. However, the role of the renal circadian clocks remains largely unknown.
Bollinger, Camille Ansermet, David Mordasini, Dmitri Firsov, Gabriel Centeno, Hugues Henry, Marc Maillard, Moore Ede, Natsuko Tokonami, Olivier Bonny, Robert Koesters, Svetlana Nikolaeva, Sylvain Pradervand, Vincent Bize   +13 more
core   +1 more source

Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription

Acta Pharmaceutica Sinica B, 2020
Various medicinal ingredients with different tastes are combined according to the theory of compatibility in Chinese materia medica to achieve a better efficacy, while the mechanism was not very clear.
Ze Wang, Haihua Shang, Yazhuo Li, Chen Zhang, Yan Dong, Tao Cui, Hongbing Zhang, Xiaoyan Ci, Xiulin Yi, Tiejun Zhang, Fengying Yan, Yaping Zhang, Xing Huang, Weidang Wu, Changxiao Liu   +14 more
doaj   +1 more source

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. [PDF]

, 2019
Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects ...
Boerwinkle, Eric, Cheung, Kit Wun Kathy, Chien, Huan-Chieh, Feofanova, Elena V, Giacomini, Kathleen M, Irannejad, Roshanak, Kinchen, Jason M, Stecula, Adrian, Suhre, Karsten, van Borselen, Marjolein, Yee, Sook Wah, Yousri, Noha A, Yu, Bing, Zou, Ling   +13 more
core   +2 more sources

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning [PDF]

Journal of Biological Chemistry, 2020
The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), the main kidney elimination pathways for many common drugs, are often considered to have largely-redundant roles. However, whereas examination of metabolomics data from Oat-knockout mice (Oat1 and Oat3KO) revealed considerable overlap, over a hundred metabolites were ...
Anisha K. Nigam, Julia G. Li, Kaustubh Lall, Da Shi, Kevin T. Bush, Vibha Bhatnagar, Ruben Abagyan, Sanjay K. Nigam   +7 more
openaire   +4 more sources