Results 21 to 30 of about 3,886 (197)

Transporter-Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT A whole‐body mechanistic PBPK model for meropenem (MPN) was developed in PK‐Sim and validated using published plasma and tissue concentration–time data in healthy volunteers and critically ill patients. Renal elimination was implemented as glomerular filtration plus active tubular secretion (basolateral uptake via OAT3 with apical efflux), and
Olivo LB, de Lemos JLS, Rodrigues VJ, de Araújo BV.   +3 more
europepmc   +2 more sources

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity [PDF]

Clinical and Translational Science, 2017
AbstractCisplatin is among the most widely used anticancer drugs and known to cause a dose‐limiting nephrotoxicity, which is partially dependent on the renal uptake carrier OCT2. We here report a previously unrecognized, OCT2‐independent pathway of cisplatin‐induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3.
Hu, S, Leblanc, AF, Gibson, AA, Hong, KW, Kim, JY, Janke, LJ, Li, L, Vasilyeva, A, Finkelstein, DB, Sprowl, JA, Sweet, DH, Schlatter, E, Ciarimboli, G, Schellens, JHM, Baker, SD, Pabla, N, Sparreboom, A   +16 more
openaire   +2 more sources

OAT3 mediates methotrexate resistance in the treatment of rheumatoid arthritis

Biomedicine & Pharmacotherapy, 2022
To study whether organic anion transporter 3 (OAT3) is involved in the development of methotrexate (MTX) resistance in the treatment of rheumatoid arthritis.The experimental components of the animals were the normal group, collagen-induced arthritis (CIA) model group, and MTX treatment group.
Jinzhang, Gao, Ning, Xiao, Qianlei, Wang, Zhengkun, Xu, Feng, Xiao, Zhaoyi, Yang, Wei, Wei, Chun, Wang   +7 more
openaire   +2 more sources

The Prescription of Drugs That Inhibit Organic Anion Transporters 1 or 3 Is Associated with the Plasma Accumulation of Uremic Toxins in Kidney Transplant Recipients

Toxins, 2021
The renal elimination of uremic toxins (UTs) can be potentially altered by drugs that inhibit organic anion transporters 1/3 (OAT1/OAT3). The objective of the present study was to determine whether the prescription of at least one OAT1/OAT3 inhibitor was
Camille André, Touria Mernissi, Gabriel Choukroun, Youssef Bennis, Saïd Kamel, Sophie Liabeuf, Sandra Bodeau   +6 more
doaj   +1 more source

Unbound Intrinsic Formation Clearance of 6β‐Hydroxycortisol Is a Useful Biomarker of CYP3A4 Activity during Pregnancy [PDF]

Clin Pharmacol Ther
Pregnancy results in multiple physiological changes that impact drug disposition. For example, hepatic CYP3A activity and renal transporter‐mediated clearance increase in late pregnancy, but the time course of these changes across pregnancy is not known.
Authement A, Hebert M, Fay E, Isoherranen N.   +3 more
europepmc   +2 more sources

Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model

Pharmaceutics, 2022
Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional.
Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xin’an Wu   +4 more
doaj   +1 more source

Human OAT1, OAT3, OAT4 and OATP1A2 Facilitate the Renal Accumulation of Ochratoxin A. [PDF]

Pharmaceutics
Background/Objectives: Ochratoxin A (OTA) is a widespread foodborne mycotoxin linked to chronic kidney disease of unknown etiology. Despite evidence from animal models showing OTA accumulation in the kidney, the molecular mechanisms underlying its renal disposition in humans remain only partially understood. Here.
Mahadeo A, Tsang YP, Zheng AR, Arnzen S, Rodriguez AG, Warren MS, Gáborik Z, Kelly EJ.   +7 more
europepmc   +3 more sources

Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule

Pharmaceutics, 2020
Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters.
Nori J. L. Smeets, Carlijn H. C. Litjens, Jeroen J. M. W. van den Heuvel, Hedwig van Hove, Petra van den Broek, Frans G. M. Russel, Jan B. Koenderink, Saskia N. de Wildt   +7 more
doaj   +1 more source

Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid

Pharmaceutics, 2021
We investigated the involvement of drug transporters in the pharmacokinetics of rosmarinic acid in rats as well as the transporter-mediated drug interaction potential of rosmarinic acid in HEK293 cells overexpressing clinically important solute carrier ...
Yun Ju Kang, Chul Haeng Lee, Soo-Jin Park, Hye Suk Lee, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Effects of islatravir (4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters

Journal of Pharmacological Sciences, 2021
Islatravir (ISL; 4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) is a novel reverse transcriptase translocation inhibitor and has a unique structure and high antiviral activity against wild-type and multidrug resistant HIV strains.
Meika Kaneko, Yoshie Reien, Hanae Morio, Tomoko Fukuuchi, Kiyoko Kaneko, Yuri Hirayama, Hirofumi Hashimoto, Nobuyo Kuwata, Hiroaki Mitsuya, Naohiko Anzai   +9 more
doaj   +1 more source