Results 31 to 40 of about 21,525 (288)
Molecular Mechanism of Ochratoxin A Transport in the Kidney
Toxins, 2010 The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver.
Naohiko Anzai +2 more
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Pharmacokinetics and Toxicokinetics Roles of Membrane Transporters at Kidney Level
Journal of Pharmacy & Pharmaceutical Sciences, 2020 Transporters are large membrane proteins, which control the passage of various compounds through biological membranes. These proteins are divided into uptake and efflux transporters and play an important role in the toxicokinetics of many endobiotics and
Jéssica Veiga-Matos +2 more
doaj +1 more source
Introduction of Organic Anion Transporters (SLC22A) and a Regulatory Mechanism by Caveolins [PDF]
, 2006 The kidney is an important organ for controlling the volume of body fluids, electrolytic balance and excretion/reabsorption of endogenous and exogenous compounds.
이운규
core +1 more source
Enantioselective Drug Recognition by Drug Transporters
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
doaj +1 more source
Drug Design, Development and Therapy, 2015 We investigated the in vitro transport characteristics of catalposide in HEK293 cells overexpressing organic anion transporter 1 (OAT1), OAT3, organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, organic cation transporter 1 (OCT1), OCT2, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP).
Jeong,Hyeon-Uk +6 more
openaire +6 more sources
Frontiers in Pharmacology, 2021 The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process.
Wei Zou +9 more
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Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family
European Thyroid Journal, 2023 Objective: Thyroid hormone (TH) transport represents a critical first step in governing intracellular TH regulation. It is still unknown whether the full repertoire of TH transporters has been identified.
Zhongli Chen +11 more
doaj +1 more source
Renal drug transporters and their significance in drug–drug interactions
Acta Pharmaceutica Sinica B, 2016 The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules
Jia Yin, Joanne Wang
doaj +1 more source
The Role of Mitochondria in Drug-Induced Kidney Injury
Frontiers in Physiology, 2020 The kidneys utilize roughly 10% of the body’s oxygen supply to produce the energy required for accomplishing their primary function: the regulation of body fluid composition through secreting, filtering, and reabsorbing metabolites and nutrients.
Zhibo Gai +7 more
doaj +1 more source
Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells
Pharmaceutics, 2016 Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transporter
Elodie Jouan +4 more
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