Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia [PDF]
, 2013 <p>Background Comparative analysis of tissue-specific transcriptomes is a powerful technique to uncover tissue functions. Our FlyAtlas.org provides authoritative gene expression levels for multiple tissues of Drosophila melanogaster (1).
Chintapalli, V.R. +4 more
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Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells
Pharmaceutics, 2016 Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transporter
Elodie Jouan +4 more
doaj +1 more source
Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. [PDF]
PLoS ONE, 2017 Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of
Lisa Chedik +7 more
doaj +1 more source
Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]
, 2017 We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
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Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. [PDF]
, 2019 Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects ...
Boerwinkle, Eric +13 more
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Frontiers in Pharmacology, 2023 Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers.
Kakeru Sato +12 more
doaj +1 more source
Ciprofloxacin is actively transported across bronchial lung epithelial cells using a calu-3 air interface cell model [PDF]
, 2013 Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown.
Bebawy, M, Ong, HX, Traini, D, Young, PM
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Molecular pharmacology of renal organic anion transporters [PDF]
American Journal of Physiology-Renal Physiology, 2000 Renal organic anion transport systems play an important role in the elimination of drugs, toxic compounds, and their metabolites, many of which are potentially harmful to the body. The renal proximal tubule is the primary site of carrier-mediated transport from blood to urine of a wide variety of anionic substrates.
Aubel, R.A.M.H. van +2 more
openaire +3 more sources
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. [PDF]
, 2008 Objective: Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKCa agonist.
Beuers, U. +5 more
core +1 more source
Assessment of the Drug Interaction Potential of Unconjugated and GalNAc3-Conjugated 2′-MOE-ASOs
Molecular Therapy: Nucleic Acids, 2017 Antisense oligonucleotides are metabolized by nucleases and drug interactions with small drug molecules at either the cytochrome P450 (CYP) enzyme or transporter levels have not been observed to date.
Colby S. Shemesh +13 more
doaj +1 more source