Results 21 to 30 of about 2,175,797 (285)

Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition

Pharmaceutics, 2023
Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the brain, facilitating their entry into the central nervous system (CNS).
Md Masud Parvez, Armin Sadighi, Yeseul Ahn, Steve F. Keller, Julius O. Enoru   +4 more
doaj   +1 more source

Interactions of organophosphate flame retardants with human drug transporters

Ecotoxicology and Environmental Safety, 2023
Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible
Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère, Olivier Fardel   +6 more
doaj   +1 more source

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance

Pharmaceutics, 2020
The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj   +1 more source

Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

Pharmaceutics, 2021
In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals.
Anisha K. Nigam, Anupam A. Ojha, Julia G. Li, Da Shi, Vibha Bhatnagar, Kabir B. Nigam, Ruben Abagyan, Sanjay K. Nigam   +7 more
doaj   +1 more source

The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of Moringa oleifera Lam. Leaves against Hyperuricemia Mice

Molecules, 2022
The aim of this study is to evaluate the anti-hyperuricemia effect and clarify the possible mechanisms of flavonoids and phenolics of MOL (MOL-FP) in mice.
Xiaowei Luo, Lipeng Zhou, Shukai Wang, Jing Yuan, Zihao Chang, Qian Hu, Yinxin Chen, Yuqi Liu, Ya Huang, Baojin Wang, Ye Gao, Zhaohui Wang, Yitong Cui, Yue Liu, Lanzhen Zhang   +14 more
doaj   +1 more source

OATP2B1 - the underrated member of the Organic Anion Transporting Polypeptide Family of drug transporters?

Biochemical Pharmacology, 2021
The organic anion transporting polypeptide 2B1 (OATP2B1) was one of the first cloned members of the SLCO family. However, its physiological and pharmacological role is still poorly understood, and object of a current debate on the transporter's relevance.
Jonny Kinzi, M. Grube, H. E. Meyer zu Schwabedissen   +2 more
semanticscholar   +1 more source

Preclinical assessment of drug–drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist

Clinical and Translational Science, 2023
The objective of the current study was to identify potential drug–drug interactions (DDIs) with the drug candidate fb‐PMT, a novel anticancer thyrointegrin αvß3 antagonist.
Kazutoshi Fujioka, Mostafa I. Fekry, Jeanne M. Rumsey, Toni Steiner, David Thompson, Shaker A. Mousa   +5 more
doaj   +1 more source

Fluorinated tetrapodal anion transporters [PDF]

, 2023
Synthetic anion transporters show potential in treating life-threatening diseases like cystic fibrosis and cancer. However, with increasingly complex transporter architectures designed to control anion binding and transport, it is important to consider ...
Alexander M. Gilchrist, Xin Wu, Hibbs, DE, Gale, PA, David E. Hibbs, Philip A. Gale, Wu, X, Bryson A. Hawkins, Hawkins, BA, Gilchrist, AM   +9 more
core   +1 more source

Molecular Mechanism of Ochratoxin A Transport in the Kidney

Toxins, 2010
The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver.
Naohiko Anzai, Promsuk Jutabha, Hitoshi Endou   +2 more
doaj   +1 more source

Pharmacokinetics and Toxicokinetics Roles of Membrane Transporters at Kidney Level

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Transporters are large membrane proteins, which control the passage of various compounds through biological membranes. These proteins are divided into uptake and efflux transporters and play an important role in the toxicokinetics of many endobiotics and
Jéssica Veiga-Matos, Fernando Remião, Ana Motales   +2 more
doaj   +1 more source