Results 11 to 20 of about 43,519 (302)

Organic Anion Transporter Family: Current Knowledge

Journal of Pharmacological Sciences, 2006
.: Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in ...
Naohiko Anzai, Yoshikatsu Kanai, Hitoshi Endou   +2 more
doaj   +4 more sources

Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins

Journal of Pharmacological Sciences, 2008
Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa, Michio Takeda, Suparat Khamdang, Rie Noshiro-Kofuji, Minoru Tsuda, Surawat Jariyawat, Toshiyuki Fukutomi, Samaisukh Sophasan, Naohiko Anzai, Hitoshi Endou   +9 more
doaj   +4 more sources

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Drug Design, Development and Therapy, 2015
Hyeon-Uk Jeong,1 Mihwa Kwon,2 Yongnam Lee,3 Ji Seok Yoo,3 Dae Hee Shin,3 Im-Sook Song,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences ...
Jeong HU, Kwon M, Lee Y, Yoo JS, Shin DH, Song IS, Lee HS   +6 more
doaj   +6 more sources

Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3− Exchange [PDF]

Journal of Biological Chemistry, 1997
Organic anion transporting polypeptide (oatp) is an integral membrane protein cloned from rat liver that mediates Na+-independent transport of organic anions such as sulfobromophthalein and taurocholic acid. Previous studies in rat hepatocytes suggested that organic anion uptake is associated with base exchange.
L M, Satlin, V, Amin, A W, Wolkoff
openaire   +2 more sources

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance

Pharmaceutics, 2020
The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj   +1 more source

Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

Pharmaceutics, 2021
In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals.
Anisha K. Nigam, Anupam A. Ojha, Julia G. Li, Da Shi, Vibha Bhatnagar, Kabir B. Nigam, Ruben Abagyan, Sanjay K. Nigam   +7 more
doaj   +1 more source

SLC17: A functionally diverse family of organic anion transporters [PDF]

Molecular Aspects of Medicine, 2013
Reimer RJ.
exaly   +2 more sources

Organic Anion-Transporting Polypeptides [PDF]

, 2014
Organic anion-transporting polypeptides or OATPs are central transporters in the disposition of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of endogenous substrates. The critical role of OATPs in drug disposition has spurred research both in academia and in the pharmaceutical industry.
Stieger Bruno, Hagenbuch Bruno
openaire   +3 more sources

The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of Moringa oleifera Lam. Leaves against Hyperuricemia Mice

Molecules, 2022
The aim of this study is to evaluate the anti-hyperuricemia effect and clarify the possible mechanisms of flavonoids and phenolics of MOL (MOL-FP) in mice.
Xiaowei Luo, Lipeng Zhou, Shukai Wang, Jing Yuan, Zihao Chang, Qian Hu, Yinxin Chen, Yuqi Liu, Ya Huang, Baojin Wang, Ye Gao, Zhaohui Wang, Yitong Cui, Yue Liu, Lanzhen Zhang   +14 more
doaj   +1 more source

Preclinical assessment of drug–drug interaction of fb‐PMT, a novel anti‐cancer thyrointegrin αvβ3 antagonist

Clinical and Translational Science, 2023
The objective of the current study was to identify potential drug–drug interactions (DDIs) with the drug candidate fb‐PMT, a novel anticancer thyrointegrin αvß3 antagonist.
Kazutoshi Fujioka, Mostafa I. Fekry, Jeanne M. Rumsey, Toni Steiner, David Thompson, Shaker A. Mousa   +5 more
doaj   +1 more source