Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors. [PDF]
Drug Metab Dispos, 2015 The multispecific organic anion drug transporters OAT6 (SLC22A20) and OAT1 (SLC22A6) are expressed in nasal epithelial cells and both can bind odorants.
Wu W +5 more
europepmc +4 more sources
Organic Anion Transporter Family: Current Knowledge
Journal of Pharmacological Sciences, 2006 .: Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in ...
Naohiko Anzai +2 more
doaj +2 more sources
Interactions of Human Organic Anion Transporters With Aristolochic Acids
Journal of Pharmacological Sciences, 2010 Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu +8 more
doaj +2 more sources
Organic anion transporters and their influence on the toxicity of β-lactam antibiotics
Безопасность и риск фармакотерапии, 2018 This review article describes the classification and mechanism of action of organic anion transporters (OAT). The influence of certain members of this family of transporters on the pharmacokinetics of β-lactam antibiotics.
V. A. Evteev +5 more
doaj +1 more source
Activity of renal organic anion transporters in a model of ischemia and reperfusion injury in vitro
Сеченовский вестник, 2018 The aim of the work is to study the functional characteristics of SLC transporters of organic anions: OAT1 and OAT3 in normal conditions and in model ischemia/reperfusion injury.Materials and methods.
V. A. Evteev +4 more
doaj +2 more sources
Expression and Function of Renal and Hepatic Organic Anion Transporters in Extrahepatic Cholestasis
World Journal of Gastroenterology, 2012 Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct. The absorption, distribution and elimination of drugs are impaired during this pathology.
Maria Herminia Hazelhoff +1 more
exaly +2 more sources
Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) [PDF]
Evidence-Based Complementary and Alternative Medicine, 2012 Many active components of herbal products are small organic anions, and organic anion transporters were previously demonstrated to be a potential site of drug-drug interactions.
Li Wang, D. Sweet
semanticscholar +2 more sources
Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine
Journal of Pharmacological Sciences, 2004 We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1
Suparat Khamdang +8 more
doaj +2 more sources
Delivering anion transporters to lipid bilayers in water [PDF]
, 2021 Cyclodextrins have been employed as delivery agents for lipophilic anion transporters, which allow their incorporation into lipid bilayers without using an organic solvent or pre ...
To, Tsz Ying (Teresa) +14 more
core +3 more sources
Uremic Toxins in Organ Crosstalk
Frontiers in Medicine, 2021 Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
doaj +1 more source