Results 11 to 20 of about 21,525 (288)

Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin [PDF]

Asian Journal of Pharmaceutical Sciences, 2020
This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of ...
Yanna Zhu, Xiaokui Huo, Changyuan Wang   +2 more
exaly   +3 more sources

Interactions of Human Organic Anion Transporters With Aristolochic Acids

Journal of Pharmacological Sciences, 2010
Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion ...
Ellappan Babu, Michio Takeda, Ritsuo Nishida, Rie Noshiro-Kofuji, Masaaki Yoshida, Shiro Ueda, Toshiyuki Fukutomi, Naohiko Anzai, Hitoshi Endou   +8 more
doaj   +2 more sources

Torasemide Transport by Organic Anion Transporters Contributes to Hyperuricemia [PDF]

Journal of the American Society of Nephrology, 2007
The high renal clearance of torasemide, the most potent loop diuretic, suggests active tubular secretion in the proximal tubule. Previous studies implicated the organic anion transporters (OAT) in this process; human OAT1 (hOAT1) and hOAT3 are found on the basolateral surface of proximal ...
Hagos, Yohannes, Bahn, Andrew, Vormfelde, Stefan Viktor, Brockmoeller, Juergen, Burckhardt, Gerhard   +4 more
openaire   +4 more sources

Drug transport by Organic Anion Transporters (OATs)

Pharmacology & Therapeutics, 2012
Common to all so far functionally characterized Organic Anion Transporters (OATs) is their broad substrate specificity and their ability to exchange extracellular against intracellular organic anions. Many OATs occur in renal proximal tubules, the site of active drug secretion.
Burckhardt, Gerhard
openaire   +4 more sources

Molecular pharmacology of renal organic anion transporters [PDF]

American Journal of Physiology-Renal Physiology, 2000
Renal organic anion transport systems play an important role in the elimination of drugs, toxic compounds, and their metabolites, many of which are potentially harmful to the body. The renal proximal tubule is the primary site of carrier-mediated transport from blood to urine of a wide variety of anionic substrates.
Aubel, R.A.M.H. van, Masereeuw, R., Russel, F.G.M.   +2 more
openaire   +4 more sources

Organic anion transporters and their influence on the toxicity of β-lactam antibiotics

Безопасность и риск фармакотерапии, 2018
This review article describes the classification and mechanism of action of organic anion transporters (OAT). The influence of certain members of this family of transporters on the pharmacokinetics of β-lactam antibiotics.
V. A. Evteev, O. V. Muslimova, I. A. Mazerkina, N. D. Bunyatyan, E. V. Shikh, R. E. Kazakov   +5 more
doaj   +1 more source

β-Lactam Antibiotics—Drug-Drug Interaction Mediated by Organic Anion Transporters OAT1 and OAT3

Регуляторные исследования и экспертиза лекарственных средств, 2020
Organic anion transporters OAT1 and OAT3 play a key role in elimination of most β-lactam antibiotics. Since nonsteroidal anti-inflammatory drugs, antivirals, antitumor agents, and some other drugs are also substrates of OAT1/3, this enables drug-drug ...
I. A. Mazerkina, V. A. Evteev, A. B. Prokofiev, O. V. Muslimova, E. Yu. Demchenkova   +4 more
doaj   +3 more sources

Activity of renal organic anion transporters in a model of ischemia and reperfusion injury in vitro

Сеченовский вестник, 2018
The aim of the work is to study the functional characteristics of SLC transporters of organic anions: OAT1 and OAT3 in normal conditions and in model ischemia/reperfusion injury.Materials and methods.
V. A. Evteev, R. E. Kazakov, A. B. Prokof'ev, I. A. Mazerkina, N. D. Bunyatyan   +4 more
doaj   +2 more sources

Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

Journal of Pharmacological Sciences, 2004
We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1
Suparat Khamdang, Michio Takeda, Minoru Shimoda, Rie Noshiro, Shinichi Narikawa, Xiu-Lin Huang, Atsushi Enomoto, Pawinee Piyachaturawat, Hitoshi Endou   +8 more
doaj   +2 more sources

Uremic Toxins in Organ Crosstalk

Frontiers in Medicine, 2021
Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
doaj   +1 more source