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Anion Transport by Proteins: Protein Motifs Involved in Anion Binding
, 2022 Various cellular processes require the participation of specific anions, including Cl-, F-, I-, HCO3- and CO32-. However, their ionic charges impede their permeation across the hydrophobic lipid bilayers of the cells. Cell membranes thus contain specific macromolecular transport proteins, ion channels and transporters, to facilitate and control the ...
Damergi, Mirna
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Membranes, 2020 Transmembrane transport of monocarboxylates is conferred by structurally diverse membrane proteins. Here, we describe the pH dependence of lactic acid/lactate facilitation of an aquaporin (AQP9), a monocarboxylate transporter (MCT1, SLC16A1), and a ...
Annika Bader, Eric Beitz
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Engineered Pendrin Protein, an Anion Transporter and Molecular Motor [PDF]
Journal of Biological Chemistry, 2011 Pendrin and prestin both belong to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Pendrin (SLC26A4) is a chloride-iodide transporter that is found at the luminal membrane of follicular cells in the thyroid gland as well as in the endolymphatic duct and sac of the inner ear, whereas prestin (SLC26A5) is expressed in ...
Jie, Tang +4 more
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The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates
Frontiers in Pharmacology, 2022 Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The resulting glucuronide and sulfate conjugates are generally considered inactive and safe.
Erkka Järvinen +6 more
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A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings
Micromachines, 2020 Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano +6 more
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Expression of calcification‐related ion transporters during blue mussel larval development
Ecology and Evolution, 2019 The physiological processes driving the rapid rates of calcification in larval bivalves are poorly understood. Here, we use a calcification substrate‐limited approach (low dissolved inorganic carbon, CT) and mRNA sequencing to identify proteins involved ...
Kirti Ramesh +4 more
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Enantioselective Drug Recognition by Drug Transporters
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
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Insights into the Mechanisms Underlying Boron Homeostasis in Plants
Frontiers in Plant Science, 2017 Boron is an essential element for plants but is toxic in excess. Therefore, plants must adapt to both limiting and excess boron conditions for normal growth.
Akira Yoshinari, Junpei Takano
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Multiple ALMT subunits combine to form functional anion channels: A case study for rice ALMT7
Frontiers in Plant Science, 2022 The Aluminum Activated Malate Transporter (ALMT) family members are anion channels that play important roles in organic acid transport, stress resistance, growth, development, fertilization and GABA responses. The rice malate permeable OsALMT7 influences
Hui Zhou +4 more
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A family of fluoride-specific ion channels with dual-topology architecture
eLife, 2013 Fluoride ion, ubiquitous in soil, water, and marine environments, is a chronic threat to microorganisms. Many prokaryotes, archea, unicellular eukaryotes, and plants use a recently discovered family of F− exporter proteins to lower cytoplasmic F− levels ...
Randy B Stockbridge +3 more
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