Prediction of membrane transport proteins and their substrate specificities using primary sequence information. [PDF]
PLoS ONE, 2014 Membrane transport proteins (transporters) move hydrophilic substrates across hydrophobic membranes and play vital roles in most cellular functions. Transporters represent a diverse group of proteins that differ in topology, energy coupling mechanism ...
Nitish K Mishra +2 more
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Anion transport by the cochlear motor protein prestin
The Journal of Physiology, 2011 Non‐technical summary Cochlear inner hair cells transform acoustic signals into electric signals. Another type of hair cells, outer hair cells, actively amplifies sensory signals and thus contributes to the exquisite sensitivity of the human auditory system.
Michael, Schänzler, Christoph, Fahlke
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Monomeric erythrocyte band 3 protein transports anions. [PDF]
Proceedings of the National Academy of Sciences, 1991 The anion transport system of the human erythrocyte membrane was reconstituted in egg phosphatidylcholine membranes by using either the unmodified transport protein, band 3, or covalently crosslinked band 3 dimers. Unilamellar vesicles of a diameter of 32 +/- 3 nm were then isolated from the sample by passage through a French press and subsequent gel ...
Lindenthal, S., Schubert, D.
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Effect of a bound anion on the structure and dynamics of halorhodopsin from Natronomonas pharaonis
Structural Dynamics, 2019 Active ion transport across membranes is vital to maintaining the electrochemical gradients of ions in cells and is mediated by transmembrane proteins. Halorhodopsin (HR) functions as a light-driven inward pump for chloride ions. The protein contains all-
Misao Mizuno +3 more
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Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases. [PDF]
PLoS ONE, 2018 Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins.
Arturo Medrano-Soto +5 more
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Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]
, 2006 Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
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Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes [PDF]
, 2009 Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the ...
Oluyomi A. Okunola +13 more
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Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]
, 2010 The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter, Günter Müller
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Membrane proteins in the outer mebrane of plastids and mitochondria [PDF]
, 2006 Channels of the plastid and mitochondrial outer membranes facilitate the turnover of molecules and ions via these membranes. Although channels have been studied many questions pertaining to the whole diversity of plastid and mitochondrial channels in ...
Ilkavets, Iryna
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