Results 51 to 60 of about 80,553 (266)

Level of membrane-bound hemoglobin and red-cell membrane proteins in patients with essential hypertension complicated and not complicated with metabolic syndrome

Acta Biomedica Scientifica, 2016
We studied the effect of different levels of membrane-bound hemoglobin on the level of red-cell membrane proteins and also their interrelation in patients with essential hypertension with and without metabolic syndrome.
Y. I. Pivovarov, E. E. Kuznetsova, V. G. Gorokhova, A. S. Sergeyeva, I. V. Babushkina, L. B. Koryakina, E. O. Andreyeva   +6 more
doaj   +1 more source

Energy Metabolic Plasticity of Colorectal Cancer Cells as a Determinant of Tumor Growth and Metastasis

Frontiers in Oncology, 2021
Metabolic plasticity is the ability of the cell to adjust its metabolism to changes in environmental conditions. Increased metabolic plasticity is a defining characteristic of cancer cells, which gives them the advantage of survival and a higher ...
Leenu Reinsalu, Leenu Reinsalu, Marju Puurand, Vladimir Chekulayev, Sten Miller, Sten Miller, Igor Shevchuk, Kersti Tepp, Egle Rebane-Klemm, Egle Rebane-Klemm, Natalja Timohhina, Anton Terasmaa, Tuuli Kaambre   +12 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells

Molecular Therapy: Oncolytics, 2020
In chronic myelogenous leukemia (CML), treatment with tyrosine kinase inhibitors (TKI) is unable to eradicate leukemic stem cells (LSC). Polymethine dye-functionalized nanoparticles can be internalized by specific cell types using transmembrane carrier ...
Philipp Ernst, Adrian T. Press, Mike Fischer, Vivien Günther, Christine Gräfe, Joachim H. Clement, Thomas Ernst, Ulrich S. Schubert, Jana Wotschadlo, Marc Lehmann, Christoph Enzensperger, Michael Bauer, Andreas Hochhaus   +12 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Synopsis of the 48th Annual Meeting of the Lake Cumberland Biological Transport Group and the Second Biannual Meeting of the Pendrin Consortium

Cellular Physiology and Biochemistry, 2013
Ion transporters are the molecular basis for ion homeostasis of the cell and the whole organism. The anion exchanger pendrin is only one of a number of examples where a complete or partial loss of function and/or deregulation of expression of ion ...
Silvia Dossena, Charity Nofziger, Rossana Morabito, Norma C. Adragna, Markus Paulmichl   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

TMT-based proteomic analysis of Apocynum venetum under salt stress

Xibei zhiwu xuebao
[Objective] Apocynum venetum L. is an important wild plant germplasm in China, which has important medicinal, ecological, and economic values. Although A .
ZHEN Xi, LIU Xuyang, ZHANG Xiaoming, WAN Tao   +3 more
doaj   +1 more source

The Voltage-Dependent Anion Channels (VDAC) of Mycobacterium avium phagosome are associated with bacterial survival and lipid export in macrophages

Scientific Reports, 2017
Mycobacterium avium subsp. hominissuis is associated with infection of immunocompromised individuals as well as patients with chronic lung disease. M. avium infects macrophages and actively interfere with the host killing machinery such as apoptosis and ...
Lia Danelishvili, Jessica J. J. Chinison, Tuan Pham, Rashmi Gupta, Luiz E. Bermudez   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source