Results 61 to 70 of about 3,774,880 (304)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Journal of Nanobiotechnology, 2022
The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kidney tubule, but still lack the expression of ...
Rafael Soares Lindoso, Fjodor A. Yousef Yengej, Franziska Voellmy, Maarten Altelaar, Estela Mancheño Juncosa, Theano Tsikari, Carola M. E. Ammerlaan, Bas W. M. Van Balkom, Maarten B. Rookmaaker, Marianne C. Verhaar, Rosalinde Masereeuw   +10 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Secondary water pore formation for proton transport in a ClC exchanger revealed by an atomistic molecular dynamics simulation [PDF]

, 2008
Several prokaryotic ClC proteins have been demonstrated to function as exchangers that transport both chloride ions and protons simultaneously in opposite directions.
Youn Jo Ko, Won Ho Jo
core  

Carrier-Mediated and Energy-Dependent Uptake and Efflux of Deoxynivalenol in Mammalian Cells

Scientific Reports, 2017
Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans and animals. To date, the transporting mechanism of DON in mammalian cells remains unclear. In this study, the parallel artificial membrane permeability
Xiaoming Li, Peiqiang Mu, Jikai Wen, Yiqun Deng   +3 more
doaj   +1 more source

Level of membrane-bound hemoglobin and red-cell membrane proteins in patients with essential hypertension complicated and not complicated with metabolic syndrome

Acta Biomedica Scientifica, 2016
We studied the effect of different levels of membrane-bound hemoglobin on the level of red-cell membrane proteins and also their interrelation in patients with essential hypertension with and without metabolic syndrome.
Y. I. Pivovarov, E. E. Kuznetsova, V. G. Gorokhova, A. S. Sergeyeva, I. V. Babushkina, L. B. Koryakina, E. O. Andreyeva   +6 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Anion channel sensitivity to cytosolic organic acids implicates a central role for oxaloacetate in integrating ion flux with metabolism in stomatal guard cells [PDF]

, 2011
Stomatal guard cells play a key role in gas exchange for photosynthesis and in minimizing transpirational water loss from plants by opening and closing the stomatal pore.
Yizhou Wang, Blatt, Michael R., Wang, Yizhou, Wang, Y., Michael R. Blatt, Blatt, M.R.   +5 more
core   +1 more source

Synopsis of the 48th Annual Meeting of the Lake Cumberland Biological Transport Group and the Second Biannual Meeting of the Pendrin Consortium

Cellular Physiology and Biochemistry, 2013
Ion transporters are the molecular basis for ion homeostasis of the cell and the whole organism. The anion exchanger pendrin is only one of a number of examples where a complete or partial loss of function and/or deregulation of expression of ion ...
Silvia Dossena, Charity Nofziger, Rossana Morabito, Norma C. Adragna, Markus Paulmichl   +4 more
doaj   +1 more source