Results 71 to 80 of about 3,774,880 (304)

Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells

Molecular Therapy: Oncolytics, 2020
In chronic myelogenous leukemia (CML), treatment with tyrosine kinase inhibitors (TKI) is unable to eradicate leukemic stem cells (LSC). Polymethine dye-functionalized nanoparticles can be internalized by specific cell types using transmembrane carrier ...
Philipp Ernst, Adrian T. Press, Mike Fischer, Vivien Günther, Christine Gräfe, Joachim H. Clement, Thomas Ernst, Ulrich S. Schubert, Jana Wotschadlo, Marc Lehmann, Christoph Enzensperger, Michael Bauer, Andreas Hochhaus   +12 more
doaj   +1 more source

Regorafenib Is Transported by the Organic Anion Transporter 1B1 and the Multidrug Resistance Protein 2

Biological & Pharmaceutical Bulletin, 2015
Regorafenib is a small molecule inhibitor of tyrosine kinases, and has been shown to improve the outcomes of patients with advanced colorectal cancer and advanced gastrointestinal stromal tumors. The transport profiles of regorafenib by various transporters were evaluated.
Ohya, Hiroki, Shibayama, Yoshihiko, Ogura, Jiro, Narumi, Katsuya, Kobayashi, Masaki, Iseki, Ken   +5 more
openaire   +3 more sources

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs [PDF]

Proceedings of the National Academy of Sciences, 2000
Two prominent members of the ATP-binding cassette superfamily of transmembrane proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), can mediate the cellular extrusion of xenobiotics and (anticancer) drugs from normal and tumor cells.
Wijnholds, J., Mol, C. A., van Deemter, L., de Haas, M., Scheffer, G. L., Baas, F., Beijnen, J. H., Scheper, R. J., Hatse, S., de Clercq, E., Balzarini, J., Borst, P.   +11 more
openaire   +4 more sources

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Distal renal tubular acidosis developments in its diagnosis and pathophysiology [PDF]

, 2010
This thesis describes two groups of experiments, both relating to the condition of distal renal tubular acidosis (dRTA). In the first, an alternative diagnostic test of dRTA to the ‘gold standard’ short ammonium chloride (NH4Cl) test was assessed ...
Walsh, S.B.
core  

Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites [PDF]

, 2014
EH and TAW acknowledge support from the Marie Curie Fellowship Programme (HTTP://cordis.europa.eu/fp7/home_en.html). ERSK, JML and TME acknowledge support from the Wellcome Trust (www.wellcome.ac.uk/).
Eva Heinz (105025), Hirt, R.P., Edmund R. S. Kunji (669696), Williams, Tom A, Goldberg, A.V., Robert P Hirt, Hacker Christian, T Martin Embley, Robert P. Hirt (124609), Kunji, E.R.S., Nakjang, Sirintra, Hirt, Robert, Kunji, Edmund R S, John M. Lucocq (124603), Embley, T. Martin, Christian Hacker (124601), Edmund R S Kunji, Alina V. Goldberg (124596), Heinz, Eva, John Mifsud (669694), Lucocq, John M., Alison Gregory, Embley T. Martin, Dean, P., Hirt, Robert P., Goldberg, Alina V, Heinz, E., Nakjang Sirintra, T. Martin Embley (124611), Williams Tom A., Sirintra Nakjang (124590), Kunji, Edmund R. S., Kunji, Edmund, John M Lucocq, Gregory, Alison, Goldberg, Alina, Goldberg Alina V., Tom A Williams, Tom A. Williams (124587), Gregory, A., Lucocq John M., Embley, T Martin, Paul Dean (35800), Heinz Eva, Dean, Paul; id_orcid, John Mifsud, Williams, Tom A., Lucocq, John M, Hirt Robert P., Alina V Goldberg, Dean, Paul, Hirt, Robert P, Paul Dean, Nakjang, S., Embley, T, Sirintra Nakjang, Gregory Alison, Dean Paul, Goldberg, Alina V., Mifsud, John, Lucocq, John, Williams, T.A., Mifsud John, Christian Hacker, Alison Gregory (669695), Embley, T.M., Williams, Tom, Eva Heinz, Hacker, Christian, Hacker, C., Kunji, Edmund R.S., Mifsud, J., Kunji Edmund R. S.   +72 more
core   +1 more source

Reversible photo-control over transmembrane anion transport using visible-light responsive supramolecular carriers [PDF]

, 2020
Ion transport across lipid bilayer membranes in biology is controlled by membrane proteins, which in turn are regulated in response to chemical-, physical- and photo-stimuli.
Matthew, Langton, Kerckhoffs, Aidan, Langton, Matthew J, Aidan, Kerckhoffs   +3 more
core   +3 more sources

TMT-based proteomic analysis of Apocynum venetum under salt stress

Xibei zhiwu xuebao
[Objective] Apocynum venetum L. is an important wild plant germplasm in China, which has important medicinal, ecological, and economic values. Although A .
ZHEN Xi, LIU Xuyang, ZHANG Xiaoming, WAN Tao   +3 more
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

The Voltage-Dependent Anion Channels (VDAC) of Mycobacterium avium phagosome are associated with bacterial survival and lipid export in macrophages

Scientific Reports, 2017
Mycobacterium avium subsp. hominissuis is associated with infection of immunocompromised individuals as well as patients with chronic lung disease. M. avium infects macrophages and actively interfere with the host killing machinery such as apoptosis and ...
Lia Danelishvili, Jessica J. J. Chinison, Tuan Pham, Rashmi Gupta, Luiz E. Bermudez   +4 more
doaj   +1 more source