Results 21 to 30 of about 509 (131)

A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter. [PDF]

PLoS Genetics, 2015
Previously, we proposed a rare autosomal recessive inherited enteropathy characterized by persistent blood and protein loss from the small intestine as chronic nonspecific multiple ulcers of the small intestine (CNSU).
Junji Umeno, Tadakazu Hisamatsu, Motohiro Esaki, Atsushi Hirano, Naoya Kubokura, Kouichi Asano, Shuji Kochi, Shunichi Yanai, Yuta Fuyuno, Katsuyoshi Shimamura, Naoki Hosoe, Haruhiko Ogata, Takashi Watanabe, Kunihiko Aoyagi, Hidehisa Ooi, Kenji Watanabe, Shigeyoshi Yasukawa, Fumihito Hirai, Toshiyuki Matsui, Mitsuo Iida, Tsuneyoshi Yao, Toshifumi Hibi, Kenjiro Kosaki, Takanori Kanai, Takanari Kitazono, Takayuki Matsumoto   +25 more
doaj   +5 more sources

Chronic Nonspecific Multiple Ulcers of the Small Intestine / Chronic Enteropathy Associated with SLCO2A1 Gene (CEAS)

Nippon Daicho Komonbyo Gakkai Zasshi, 2021
Chronic nonspecific multiple ulcers of the small intestine are a disease characterized by multiple small intestinal ulcers without any histopathologic specificity.
J. Umeno, Y. Fuyuno, Y. Matsuno, T. Torisu   +3 more
semanticscholar   +3 more sources

Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene: Hypotheses and conundrums. [PDF]

World J Gastroenterol
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss. This review explores the potential mechanisms underlying the pathogenesis of CEAS, focusing on the role of SLCO2A1 -encoded prostaglandin transporter ...
Xie ZX, Li Y, Yang AM, Wu D, Wang Q.
europepmc   +3 more sources

Chronic enteropathy associated with solute carrier organic anion transporter family member <i>2A1</i> gene: A case report and review of literature. [PDF]

World J Gastrointest Endosc
BACKGROUND Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 (SLCO2A1) (CEAS) is a rare autosomal recessive hereditary disease characterized by anemia, hypoproteinemia, abdominal pain, diarrhea, and multiple ...
Wang JY, Liu Y, Xu J, Fan F, You P, Peng T, Liu YL, Chen N.   +7 more
europepmc   +2 more sources

A novel variant in the SLCO2A1 gene in a Chinese patient with chronic gastroenteropathy and primary hypertrophic osteoarthropathy

Orphanet Journal of Rare Diseases
Background Chronic enteropathy associated with SLCO2A1 gene (CEAS) results from loss-of-function variants in SLCO2A1, which encodes the prostaglandin transporter (PGT). CEAS follows an autosomal recessive inheritance pattern.
Yimin Dai, Miao He, Hui Xu, Bei Tan, Weixun Zhou, Wei Liu, Qiang Wang, Jingyi Huang, Qing Shang, Yaping Liu, Yue Li   +10 more
doaj   +2 more sources

Monogenic SLCO2A1 gene mutation presenting as early onset inflammatory bowel disease-A report of rare case with review of literature

Indian Journal of Pathology and Microbiology
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a rare, autosomal recessive disorder characterized by multiple chronic ulcerative and structuring lesions in the small intestine, primarily affecting the ileum.
Mukund Namdev Sable, M. Shameema Farween, Susama Patra, Saswati Kar, Subash Chandra Samal   +4 more
doaj   +2 more sources

Reversible atransferrinemia in a patient with chronic enteropathy: is transferrin mandatory for iron transport? [PDF]

Biochem Med (Zagreb), 2023
Herein, we report the case of a 42-year-old woman, hospitalized in a French tertiary hospital for a relapse of a chronic enteropathy, who was found on admission to have no detectable serum transferrin. Surprisingly, she only exhibited mild anaemia.
Raynor A, Stefanescu C, Bruneel A, Puy H, Peoc'h K, Manceau H.   +5 more
europepmc   +4 more sources

Immune-mediated inflammatory diseases of the gastrointestinal tract: Beyond Crohn's disease and ulcerative colitis. [PDF]

JGH Open, 2022
Immune‐mediated inflammatory diseases (IMIDs) of the gastrointestinal tract including inflammatory bowel disease (IBD) are a diverse group of complex inflammatory diseases that share similar pathophysiology. IMIDs other than IBD can have similar clinical features causing diagnostic and therapeutic challenges.
Vuyyuru SK, Kedia S, Sahu P, Ahuja V.
europepmc   +2 more sources

P129 USEFULNESS OF PROSTAGLANDIN E-MAJOR URINARY METABOLITE MEASUREMENT FOR THE DIFFERENTIATION BETWEEN CHRONIC ENTEROPATHY ASSOCIATED WITH SLCO2A1 GENE (CEAS) AND CROHN’S DISEASE [PDF]

Inflammatory Bowel Diseases, 2018
Y. Matsuno, J. Umeno, Y. Fuyuno, Yasuharu Okamoto, Shigeyoshi Yasukawa, Fumihito Hirai, Kenji Watanabe, Naoki Hosoe, S. Kochi, K. Kurahara, T. Yao, T. Kitazono, T. Matsumoto, M. Esaki   +13 more
semanticscholar   +2 more sources

Chronic Enteropathy Associated with the SLCO2A1 Gene: A Case Report

Journal of the College of Physicians and Surgeons Pakistan

semanticscholar   +2 more sources