Results 231 to 240 of about 2,157,209 (306)

PPAR-γ participates in macrophage polarization induced by Pentatrichomonas hominis. [PDF]

Med Microbiol Immunol
Zheng Y, Yue TT, Zhang XC, Li JH, Gong PT, Wang XC, Li X, Zhang X, Zhang N.   +8 more
europepmc   +1 more source

Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review

The FEBS Journal, EarlyView.
This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas, Lucas Vinícius Souza Santos, André Gustavo Carvalho de Oliveira, Marina dos Santos Barreto, Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Eloia Emanuelly Dias Silva, Ronaldy Santana Santos, Lucas Alves da Mota Santana, Rajiv Gandhi Gopalsamy, Adriana Gibara Guimarães, Lysandro Pinto Borges   +11 more
wiley   +1 more source

Contribution of local <i>Salmonella</i> infection to autoreactivity: divergent roles of type I interferons in colonization and autoantibody production. [PDF]

mBio
Bessho S, Grando KCM, Olubajo S, Kowal AT, Miller AL, Lee MH, Tam V, Klein-Szanto AJ, Wilson RP, Gallucci S, Tükel Ç.   +10 more
europepmc   +1 more source

Tigecycline combination therapy for fulminant Clostridioides difficile infection: an Australian experience

Internal Medicine Journal, EarlyView.
Abstract Background Recent European Society of Clinical Microbiology and Infection and Australasian Society of Infectious Diseases Clostridioides difficile infection (CDI) management guidelines endorse the addition of intravenous tigecycline in patients who are progressing to fulminant infection.
Emma Bishop, Tanya Ravipati, Steven Mileto, Eugene Athan, Dena Lyras, Ravindranath Tiruvoipati   +5 more
wiley   +1 more source

Ethanol exposure is associated with spatial and taxon-specific gut microbiota remodeling characterized by ecological adaptation rather than broad activation of microbial ethanol metabolism. [PDF]

Gut Microbes
Li M, Mao J, Liu S, Yu H, Qin H, Liu X, Tu R, Chen S, Liu Z, Zhang S, Mao J.   +10 more
europepmc   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

Colon-Specific Delivery of Febuxostat via an Amino Acid Conjugate Enhances Anti-Colitis Efficacy and Limits Systemic Exposure. [PDF]

Pharmaceutics
Kim S, Ju S, Jung Y.
europepmc   +1 more source

A PD1‐CD137L Fusion Protein More Potently Enhances Anti‐Tumour Immune Responses Than Targeting PD‐L1 and CD137 Separately

Immunology, EarlyView.
A PD1‐CD137L fusion protein converts the immunoinhibitory PD‐L1 to an immunostimulatory signal and is more effective than targeting PD‐L1 and CD137 separately. ABSTRACT Tumour immune evasion frequently involves PD‐L1‐mediated inhibition of T cell activity, limiting the efficacy of PD1/PD‐L1 blockade, particularly in PD‐L1‐low or immunologically ‘cold ...
Runze Xia, Emily Pauline Nickles, Yu Mei, Thamizhanban Manoharan, Yi Tian Png, Beijia Liu, Rui Sun, Kang Yi Lee, Gloryn Chia, Chwee Ming Lim, Herbert Schwarz   +10 more
wiley   +1 more source

Dietary Bile Acid Supplementation Improves Lipid Metabolism and Selected Egg Quality Traits in Late-Phase Laying Hens Fed a High-Fat Diet and Is Associated with Alterations in Gut Microbiota. [PDF]

Animals (Basel)
Ma C, Liang M, Wang Z, Teng G, Xue J, Ma J, Li R, Qin M.   +7 more
europepmc   +1 more source

Nodular Lesions in the Pyloric Caeca of Sardinella aurita (Teleostei) Associated With the Cestode Anthobothrium sp. 1 Larvae (Platyhelminthes: Eucestoda) Off Tunisia, Mediterranean Sea

Journal of Fish Diseases, EarlyView.
ABSTRACT Examination of round sardinella Sardinella aurita Valenciennes, 1847 (Clupeidae) from the Gulf of Tunis (Tunisia) revealed the first local and Mediterranean record of Anthobothrium sp. 1 sensu Jensen & Bullard, 2010 (Tetraphyllidea incertae sedis, Anthobothrium).
Chiraz Ben Saad, Jean‐Lou Justine, Jihene Jouini, Delphine Gey, Stefan Theisen, Harry W. Palm, Lamia Gargouri   +6 more
wiley   +1 more source