Results 61 to 70 of about 5,449 (190)

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari, Sepideh Elyasi, Farshad Abedi   +2 more
wiley   +1 more source

Detection of OXA‐23 Among Carbapenem‐Resistant Acinetobacter baumannii Isolated From Intensive Care Units of a Tertiary Care Hospital in Pakistan

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Graphical Abstract of the Experimental Workflow for CRAB Isolate Characterization. ABSTRACT Carbapenem‐resistant Acinetobacter baumannii (CRAB) has been designated a top‐priority critical pathogen by the World Health Organization, and the CDC has also classified it as a serious and immediate public health threat. The Cross‐sectional study was conducted
Hafsa Waseem, Ihsan Ullah, Shahzad Ahmad, Irfan Ali Mirza, Benish Aleem, Shazia Iqbal   +5 more
wiley   +1 more source

Continuous infusion of cefiderocol in a critically ill patient with continuous venovenous haemofiltration [PDF]

, 2023
Cefiderocol is a broad-spectrum cephalosporin antibiotic and is indicated in patients with difficult-to-treat Gram-negative bacterial infections. Cefiderocol is applied as a 2–4-times daily prolonged 3-h infusion.
van Luin, Matthijs, Zahr, Noël, Uijtendaal, Esther V., Sikma, Maaike A., Möhlmann, Julia E.   +4 more
core  

Cefiderocol Versus Colistin for the Treatment of Carbapenem-Resistant Acinetobacter baumannii Complex Bloodstream Infections: A Retrospective, Propensity-Score Adjusted, Monocentric Cohort Study

Infectious Diseases and Therapy, 2023
Introduction Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are associated with high mortality with limited treatment.
Davide Fiore Bavaro, Roberta Papagni, Alessandra Belati, Lucia Diella, Antonio De Luca, Gaetano Brindicci, Nicolò De Gennaro, Francesco Di Gennaro, Federica Romanelli, Stefania Stolfa, Luigi Ronga, Adriana Mosca, Francesco Pomarico, Maria Dell’Aera, Monica Stufano, Lidia Dalfino, Salvatore Grasso, Annalisa Saracino   +17 more
doaj   +1 more source

In Vitro Antimicrobial Activity of the Siderophore Cephalosporin Cefiderocol against Acinetobacter baumannii Strains Recovered from Clinical Samples

Antibiotics, 2021
Background: Cefiderocol is a siderophore cephalosporin that exhibits antimicrobial activity against most multi-drug resistant Gram-negative bacteria, including Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas ...
Davide Carcione, Claudia Siracusa, Adela Sulejmani, Roberta Migliavacca, Alessandra Mercato, Aurora Piazza, Luigi Principe, Nicola Clementi, Nicasio Mancini, Valerio Leoni, Jari Intra   +10 more
doaj   +1 more source

An Assessment Of Cefiderocol's Synergistic Effects With Eravacycline, Colistin, Meropenem, Levofloxacin, Ceftazidime/Avibactam, And Tobramycin Against Carbapenem-Resistant Pseudomonas Aeruginosa

Journal of Global Antimicrobial Resistance
OBJECTIVES: This research examines the combined in vitro effectiveness of cefiderocol with other antibiotics against carbapenem-resistant Pseudomonas aeruginosa (CR-PA) obtained from Intensive Care Units.
Bekir Özer, Emel Mataraci Kara, Mesut Yılmaz, Berna Özbek Çelik   +3 more
doaj   +1 more source

Antimicrobial Resistance of Serratia marcescens Recovered From Aquatic Environments: A Review

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Serratia marcescens is a gram‐negative bacillus forming biofilms and showing multidrug resistance. Review (2019–2024) included 13 studies, 90 aquatic isolates. High resistance to β‐lactams, including carbapenems. Genes: blaOXA‐48, blaTEM‐1, aac(6′)‐Ic. Aquatic environments are reservoirs, requiring monitoring and control to prevent spread.
Heloisa Silva Inacio, Yasmim Raffaela Soares Santos, Magna Cristina de Paiva, Jaqueline Maria Siqueira Ferreira   +3 more
wiley   +1 more source

Higher rates of cefiderocol resistance among NDM producing Klebsiella bloodstream isolates applying EUCAST over CLSI breakpoints

, 2023
Background: Cefiderocol is generally active against carbapenem-resistant Klebsiella spp. (CRK) with higher MICs against metallo-beta-lactamase producers. There is a variation in cefiderocol interpretive criteria determined by EUCAST and CLSI.

core   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Tissue and Serum Concentrations of Time‐Dependent Antibiotics in Infected Diabetic Foot Ulcers by Bolus or Continuous Administration: The Randomised DFIATIM Trial

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims The clinical effectiveness of antibiotic (ATB) therapy in patients with infected diabetic foot ulcers (iDFUs) depends on achieving sufficient ATB concentrations in both serum and peripheral tissues. This study evaluated the availability and bactericidal activity of the time‐dependent ATBs—ceftazidime (CTZ) and amoxicillin/clavulanate (AMC)
Radka Jarošíková, Dominika Sojáková, Simona Antalová, Petr Tůma, Jan Polák, Michal Dubský, Andrea Němcová, Veronika Wosková, Pavol Beca, Istvan Modos, Jan Mareš, Jakub Mrázek, Chahrazed Mekadim, Markéta Skružná, Vladimíra Fejfarová   +14 more
wiley   +1 more source