Results 41 to 50 of about 5,449 (190)
Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance
Nature Communications, 2023 The rapid emergence of antimicrobial resistance (AMR) pathogens highlights the urgent need to approach this global burden with alternative strategies. Cefiderocol (Fetroja®) is a clinically-used sideromycin, that is utilized for the treatment of severe ...
Chenyuan Wang +9 more
doaj +1 more source
Carbapenem- and cefiderocol-resistant Enterobacterales in surface water in Kumasi, Ashanti Region, Ghana [PDF]
Background: MDR pathogens including ESBL- and/or carbapenemase-producing Enterobacterales (ESBL-PE and CPE) increasingly occur worldwide in the One Health context.
Eger, Elias +9 more
core +1 more source
Microbiology Spectrum, 2023 Cefiderocol and aztreonam-avibactam (ATM-AVI) both had activity against carbapenem-resistant Gram-negative bacilli, including those that produce metallo-β-lactamases (MBLs).
Yu-Shan Huang +3 more
doaj +1 more source
An Overview of Cefiderocol’s Therapeutic Potential and Underlying Resistance Mechanisms
Life, 2023 Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat (DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas aeruginosa, CR Acinetobacter baumannii, and CR- and third-generation-cephalosporins-
Sara Domingues +3 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran +5 more
wiley +1 more source
Frontiers in Pharmacology, 2021 Background: Infection is a disease that can occur due to the entrance of a virus, bacteria, and other infectious agents. Cefiderocol is innovative cephalosporin drug that belongs to a special class of antibiotics, sideromycins, which are taken up by ...
Yasaman Taheri +7 more
doaj +1 more source
Cefiderocol-associated brown chromaturia
BMJ Case Reports, 2023 Cefiderocol is a novel siderophore cephalosporin antibiotic. In the present case report, a woman in her 70s presented with a 1-week history of altered mental status and progressive purulent discharge from a non-healing diabetic foot ulcer on her right heel. MRI of the right foot revealed chronic osteomyelitis of the calcaneum.
Michael Smith, Kap Sum Foong
openaire +3 more sources
Development of cefiderocol resistance during treatment in Klebsiella pneumoniae
, 2023 International audienceBackgroundCefiderocol, a siderophore-conjugated cephalosporine, is a promising drug used to treat infection with carbapenem-resistant Gram-negative bacteria. Mutations in siderophore receptors are described to confer multiple levels
Marchand, Sandrine +4 more
core +1 more source
iLABMED, EarlyView.ABSTRACT The Clinical and Laboratory Standards Institute M100 document serves as a cornerstone standard for clinical microbiology laboratories in China. Maintaining the scientific rigor of its predecessors, the 36th edition incorporates updated epidemiological cutoff values, pharmacokinetic/pharmacodynamic data, and clinical efficacy evidence to revise
Kanghong Xu, Qi Wang, Hui Wang
wiley +1 more source
Antimicrobial Agents and ChemotherapyCefiderocol/xeruborbactam is a novel β-lactam/β-lactamase inhibitor combination in which the siderophore-cephalosporin cefiderocol is paired with xeruborbactam, a broad-spectrum inhibitor that targets class A to D β-lactamases.
Lucía González-Pinto +10 more
doaj +1 more source