Results 31 to 40 of about 4,898 (191)
Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei [PDF]
, 2023 Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria.
Bart J., Currie +11 more
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Cefiderocol and Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii [PDF]
, 2023 Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) remain a clinical challenge due to limited treatment options. Recently, cefiderocol, a novel siderophore cephalosporin, and sulbactam-durlobactam, a bactericidal β-lactam–β ...
Zarrilli R. +4 more
core +5 more sources
Cefiderocol: A Review in Serious Gram-Negative Bacterial Infections [PDF]
, 2021 Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Yahiya Y. Syed is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of ...
Yahiya Y. Syed (6594444)
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Journal of Global Antimicrobial Resistance, 2023 : Here we report the in vivo development of cefiderocol resistance within 11 days after therapy initiation in a critically ill patient with bloodstream infection, infection of peri-anal fistula, and pneumonia caused by a VIM-2 harbouring, carbapenem ...
Luise Brakert +8 more
doaj +1 more source
In vitro activity of cefiderocol against Gram-negative bacterial pathogens in Germany
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Widespread antimicrobial resistance in Gram-negative bacteria (GNB), particularly carbapenem resistance, represents a major clinical challenge.
Philipp Thelen +5 more
doaj +1 more source
Mechanism of action of cefiderocol
Revista Española de Quimioterapia, 2022 Gram-negative bacilli are intrinsically resistant to many antibiotics due to the low permeability of their outer membrane. The most effective strategy to solve this problem has been the design of antibiotics that cross the membrane using specific transport systems.
Soriano, Alex, Mensa, Josep
openaire +2 more sources
The solution to drug resistance of Gram-negative bacteria – Cefiderocol [PDF]
, 2023 Introduction: A major public health problem is the emergence of anti-gram-negative antimicrobial resistance worldwide. Cefiderocol is a new agent targeting Gram-negative bacteria, including strains with resistance to carbapenems.
Jastrzębska, Ilona +4 more
core +4 more sources
Therapeutic Advances in Urology, 2022 Cefiderocol is a unique siderophore cephalosporin antimicrobial agent that has shown promise in treating complicated urinary tract infections (cUTI). Urinary tract infections are commonly diagnosed infections with risk increasing with age and prevalence ...
Hongmei Wang, Brittany N. Palasik
doaj +1 more source
Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance
Nature Communications, 2023 The rapid emergence of antimicrobial resistance (AMR) pathogens highlights the urgent need to approach this global burden with alternative strategies. Cefiderocol (Fetroja®) is a clinically-used sideromycin, that is utilized for the treatment of severe ...
Chenyuan Wang +9 more
doaj +1 more source
Microbiology Spectrum, 2023 In this study, we aimed to comparatively evaluate the in vitro activity of cefiderocol versus other antimicrobials against a well-characterized collection of metallo-beta-lactamase (MBL)-producing Gram-negative bacilli (MBL-GNB) isolates from hospitals ...
M. Delgado-Valverde +4 more
doaj +1 more source