Experimental evolution of cefiderocol resistance in Pseudomonas aeruginosa [PDF]
HeliyonCefiderocol is a novel and promising cephalosporin approved for treating severe infections caused by Gram-negative bacteria with limited therapeutic options. One of the primary targets of cefiderocol is Pseudomonas aeruginosa, a significant opportunistic
Igor Chebotar +3 more
doaj +2 more sources
Purple-Colored Urine Induced by Cefiderocol: A Case Report and Comprehensive Literature Review [PDF]
BacteriaBackground: Purple urine discoloration, known as purple urine bag syndrome (PUBS), has various etiologies ranging from benign to serious conditions. We present a case of cefiderocol-induced PUBS and review the literature. Methods: A 56-year-old bedridden
Elie Bou Sanayeh +3 more
doaj +2 more sources
Clonal lineage and biofilm growth shape cefiderocol activity in Acinetobacter baumannii from oncology patients [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionAcinetobacter baumannii is a leading cause of healthcare-associated infections in immunocompromised patients and frequently exhibits multidrug resistance.
Ilaria Cavallo +11 more
doaj +2 more sources
Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic [PDF]
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.Synopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
M. Andrey Joaqui‐Joaqui +6 more
wiley +3 more sources
Combinatorial effects of a novel SHV-248 variant, NDM-5, and ompK35 deficiency drive high-level cefiderocol resistance in Klebsiella pneumoniae [PDF]
Microbiology SpectrumCefiderocol holds significant therapeutic value against metallo-β-lactamase-producing Enterobacterales. However, reduced susceptibility to cefiderocol in NDM-producing strains is increasingly observed.
Chuwen Zhao +7 more
doaj +2 more sources
In vitro pharmacokinetics of cefiderocol alone and in combination with antibiotics against Achromobacter spp. and Stenotrophomonas maltophilia species [PDF]
Journal of Global Antimicrobial ResistanceAIM: The point of this study was to compare and to contrast how well cefiderocol worked against a group of Achromobacter spp. and Stenotrophomonas maltophilia isolates in-vitro, both by itself and when mixed with other antibiotics.
Gokce Konyaoglu +5 more
doaj +2 more sources
Use of Cefiderocol in Adult Patients: Descriptive Analysis from a Prospective, Multicenter, Cohort Study [PDF]
Infectious Diseases and TherapyIntroduction Cefiderocol is a siderophore cephalosporin showing activity against various carbapenem-resistant Gram-negative bacteria (CR-GNB). No data currently exist about real-world use of cefiderocol in terms of types of therapy (e.g., empirical or ...
Daniele Roberto Giacobbe +52 more
doaj +8 more sources
Cefiderocol resistance genes identified in environmental samples using functional metagenomics. [PDF]
ISME JAntibiotic resistance poses a global public health threat, which can originate from the transfer of environmental antibiotic resistance genes to pathogenic bacteria, as highlighted by the “One Health” framework. Cefiderocol is a siderophore cephalosporin
Gschwind R +18 more
europepmc +3 more sources
Evolution of β-lactamase-mediated cefiderocol resistance [PDF]
, 2022 BACKGROUND: Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability toward β-lactamases, including carbapenemases, achieved by combining structural moieties of two clinically efficient cephalosporins, ceftazidime and cefepime ...
Fröhlich, Christopher +5 more
core +1 more source
Exploring mutational possibilities of KPC variants to reach high level resistance to cefiderocol [PDF]
Scientific ReportsKlebsiella pneumoniae carbapenemase (KPC) is a frequent and widespread carbapenemase, with over 260 variants identified. While KPC often evolves resistance to ceftazidime-avibactam, cefiderocol remains a key treatment option.
Sidonie Hanna +7 more
doaj +2 more sources