Results 1 to 10 of about 4,022 (166)
Microbiology Spectrum, 2022 Cefiderocol is a novel siderophore cephalosporin exhibiting potent antimicrobial activities. Although cefiderocol has not been approved in China, resistance is emerging.
Zhongju Chen +2 more
exaly +3 more sources
Frontiers in Pharmacology, 2022 Cefiderocol is a novel synthetic siderophore-conjugated antibiotic that hijacks the bacterial iron transport systems facilitating drug entry into cells, achieving high periplasmic concentrations.
Deqing Yang, Yifan Wang, Wentao Ni
exaly +3 more sources
Microbiology Spectrum, 2022 Cefiderocol has been approved in the United States and Europe but not in China. We aim to evaluate carbapenem-resistant Enterobacterales (CRE) susceptibility to cefiderocol to provide baseline data and investigate the resistance mechanism.
Longyang Jin, Yuyao Yin, Zhusheng Guo
exaly +3 more sources
Clonal lineage and biofilm growth shape cefiderocol activity in Acinetobacter baumannii from oncology patients [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionAcinetobacter baumannii is a leading cause of healthcare-associated infections in immunocompromised patients and frequently exhibits multidrug resistance.
Ilaria Cavallo +11 more
doaj +2 more sources
Combinatorial effects of a novel SHV-248 variant, NDM-5, and ompK35 deficiency drive high-level cefiderocol resistance in Klebsiella pneumoniae [PDF]
Microbiology SpectrumCefiderocol holds significant therapeutic value against metallo-β-lactamase-producing Enterobacterales. However, reduced susceptibility to cefiderocol in NDM-producing strains is increasingly observed.
Chuwen Zhao +7 more
doaj +2 more sources
Revista Española de Quimioterapia, 2022 Cefiderocol is a new siderophore cephalosporin with potent in vitro activity against gram-negative bacilli including Enterobacterales that produce all kinds of carbapenemases and non-fermenting Gram-negative with difficult-to-treat resistance. As a β-lactam, its efficacy is optimized in extended-perfusion and requires dose adjustment in renal ...
Soriano, María Cruz +2 more
+5 more sources
New mutations in genes associated with cefiderocol resistance in a clinical isolate of Pseudomonas aeruginosa [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Objective. To assess the effects of chromosomal mutations on emergence of cefiderocol resistance among Pseudomonas aeruginosa clinical isolates. Materials and Methods.
Bocharova Yu.A. +3 more
doaj +1 more source
Microbiology Spectrum, 2023 Klebsiella pneumoniae AR 0047 from the CDC and FDA Antibiotic Resistance Isolate Bank is resistant to cefiderocol, a siderophore-conjugated cephalosporin.
Sun Hee Moon, En Huang
doaj +1 more source
Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic. [PDF]
Angew Chem Int Ed EnglSynopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
Joaqui-Joaqui MA +6 more
europepmc +3 more sources
Antibiotics, 2022 The role of β-lactamases in reduced susceptibility or resistance to cefiderocol has been supported by recent reports. The purpose of this study was to investigate the in vitro impact of clinically available β-lactamase inhibitors on cefiderocol activity ...
Gabriele Bianco +7 more
doaj +1 more source