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Pharmacokinetics of Cefotaxime and Desacetyl-Cefotaxime in Cirrhosis of the Liver
Chemotherapy, 1984In 9 patients with advanced hepatic cirrhosis and a normal serum creatinine concentration, the pharmacokinetics of cefotaxime (CTX) and its desacetyl metabolite (DACM) were examined in serum and urine after intravenous administration of 2.0 g CTX. The peak serum levels were 130.3 +/- 33.9 and 8.5 +/- 4.6 mg/l for CTX and DACM, respectively.
G, Höffken +4 more
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Cefotaxime and desacetyl cefotaxime kinetics in renal impairment
Clinical Pharmacology and Therapeutics, 1985Cefotaxime and desacetyl cefotaxime kinetics after a single, 1 gm intravenous dose were evaluated in five groups of subjects: group I, normal creatinine clearance (CLCR greater than 90 ml/min); group II, mild renal insufficiency (CLCR 30 to 89 ml/min); group III, moderate renal insufficiency (CLCR 16 to 29 ml/min); group IV, severe renal insufficiency (
G R, Matzke +3 more
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Reactions Weekly, 2010
Cefotaxime is a third-generation or extended-spectrum cephalosporin which was developed in the 1970s and approved by the US Food and Drug Administration (FDA) in 1981. Cefotaxime is (6R,7R)-3-(acetyloxymethyl)-7- [[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid; its formula is
Kim, Baek-Nam, Paterson, David L.
openaire +3 more sources
Cefotaxime is a third-generation or extended-spectrum cephalosporin which was developed in the 1970s and approved by the US Food and Drug Administration (FDA) in 1981. Cefotaxime is (6R,7R)-3-(acetyloxymethyl)-7- [[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid; its formula is
Kim, Baek-Nam, Paterson, David L.
openaire +3 more sources