Results 151 to 160 of about 27,682 (272)
The Proteo‐Transcriptome of Extracellular Vesicles and Particles Is Largely Preserved After Cryopreservation
Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.ABSTRACT
Extracellular vesicles and particles (EVPs) are small lipid‐bilayer membrane structures containing proteins, lipids, and nucleic acids that play crucial roles in tumorigenesis, metastasis, and immunomodulation. The extent to which frozen tissues faithfully reflect the biology of fresh tissues remains unclear.Yohei Nose, Diane Marie del Valle, Tina Ruth Gonsalves, Kevin Tuballes, Ethan Ellis, Hui Xie, Igor Figueiredo, Ruiwei Guo, Avni Chandra, Aana Hahn, Anish Korrapati, Giorgio Ioannou, Rafael Cabal, Swapnil Tichkule, John F. Fullard, Panos Roussos, Pedro Silva, Angelo Amabile, Jarod Morgenroth‐Rebin, Travis Dawson, Raphael Merand, Kai Nie, Zhihong Chen, Sharon Nirenberg, Brian Brown, Seunghee Kim‐Schulze, Andrew Kaufman, Raja Flores, Laura Zuluaga, Kristin Beaumont, Robert Sebra, Natasha Kyprianou, Kyrollis Attalla, Ketan Badani, Ash Tewari, Navneet Dogra, Sacha Gnjatic, Edgar Gonzalez‐Kozlova +37 morewiley +1 more sourceEffectiveness and safety of ustekinumab in pediatric Crohn's disease: Results of the REALITI study
Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 5, Page 1242-1250, May 2026.Abstract Objectives
Few approved treatments exist for children with Crohn's disease (CD). The REALITI study retrospectively assessed the effectiveness and safety of ustekinumab in real‐world clinical settings for children with CD. Methods
Data were collected from the prospective ImproveCareNow (ICN) registry for pediatric patients (≥ 2 to <18 years old)Steven J. Steiner, Jeremy Adler, Shehzad A. Saeed, Richard S. Strauss, Kristin M. Howe, Anna Sheahan, Renping Zhang, Kimberly R. Keihn, Katharine Harrow, Kelly K. Olano, David A. Evans, Kim Hung Lo, Nanhua Zhang, Lilianne Kim, Richard B. Colletti, Sheri Volger, for the ImproveCareNow Learning Health Network, Sabina Ali, Rana Ammoury, Keren L. Appel, Travis Ayers, Howard Baron, Julie Bass, Rachel Bensen, Erica J. Brenner, José Cabrera, Mallory Chavannes, J Fernando del Rosario, Jill Dorsey, Dana M. H. Dykes, Dawn R. Ebach, Bhaskar Gurram, Dyer Heintz, Leslie M. Higuchi, Edward J. Hoffenberg, Jeannie S. Huang, Esther Jacobowitz Israel, Traci W. Jester, Ian Kang, Ian Leibowitz, Tiffany Linville, Ross M. Maltz, Craig A. McKinney, Lybil B. Mendoza Alvarez, Phillip Minar, Tina Morhardt, Alisa J Muñiz Crim, Barbara Joanna Niklinska‐Schirtz, Daniel M. O'Connell, Helen Pappa, Brad Pasternak, Trusha Patel, Meryl K. Perlman, Kelly C. Sandberg, Marc E. Schaefer, Robbyn E. Sockolow, David L. Suskind, Gitit Tomer, Jeanne Tung, Amanda A. Wenzel, Denise D. Young +60 morewiley +1 more sourceWhole Genome Sequencing in Prenatal Diagnostics: The Danish Approach to Guideline Formation and Implementation Within Public Healthcare
Prenatal Diagnosis, Volume 46, Issue 5-6, Page 669-686, May 2026.ABSTRACT Objective
To describe the implementation of whole genome sequencing (WGS) in prenatal diagnostics and outline the national guideline system facilitating this. Methods
Clinical guidelines for WGS in prenatal diagnostics were developed and implemented by the Danish Fetal Medicine Society.Ida Vogel, Lotte Andreasen, Marie Balslev‐Harder, Naja Becher, Anja Ernst, Kasper Gadsbøll, Tina Duelund Hjortshøj, Marie Skov Hvidbjerg, Martin Larsen, Stina Lou, Ida Charlotte Bay Lund, Lars Henning Pedersen, Laura Kirstine Sønderberg Roos, Lene Sperling, Lone Sunde, Pernille Mathiesen Tørring, Cathrine Vedel, Olav Bjørn Petersen +17 morewiley +1 more sourceEffect of rational emotive behavioral education on electoral violence behaviors. [PDF]
Medicine (Baltimore)Ezema LC, Egbule EO, Ome SO, Ugwonna GO, Aroh PN, Onyeanusi CO, Ozioko LA, Obumse NA, Ogbochie AN, Nwaubani OO, Etta AA, Nweze CA, Ede MO, Victor-Aigbodion V, Nyakuwa R. +14 moreeuropepmc +1 more sourcePhase II Randomized Study of MK‐2206 and Bicalutamide in Prostate Cancer Patients With Rising PSA After Primary Therapy (ECOG‐ACRIN E2809)
The Prostate, Volume 86, Issue 6, Page 697-709, May 2026.ABSTRACT Background
Combined inhibition of AKT and the androgen receptor (AR) might be more efficacious than AR inhibition alone in biochemical recurrence (BCR) of prostate cancer (PC) by additive effects on the two effector pathways. Patients and Methods
E2809 assigned 108 high‐risk BCR patients (1:1, arm‐A: arm‐B) to two phases with 4‐week cycles ...Anna C. Ferrari, Yu‐Hui Chen, Ronald Rodríguez, Gary R. Hudes, Emmanuel S. Antonarakis, Noah M. Hahn, Hilary Ma, Elizabeth R. Plimack, Tina Mayer, Bradley C. Carthon, Glenn Liu, Michael A. Carducci, Robert DiPaola +12 morewiley +1 more sourceCan Tanzanian Neurosurgeons Access Tanzanian Neurosurgical Literature? A Systematic Review and Survey of Neurosurgical Publications. [PDF]
NeurosurgerySabas RR, Woodfield J, Woodfield J, Ikwuegbuenyi CA, Cadieux M, Shayo C, Shabhay Z, Rabiel H, Cheserem B, Bwemelo J, Wright DN, Fivawo CS, Maghembe SM, Lawrence K, Koipapi S, Mchome LL, Mangat HS, Hartl R, Shabani HK. +18 moreeuropepmc +1 more sourceThe Alpha‐1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD
Alimentary Pharmacology &Therapeutics, Volume 63, Issue 10, Page 1380-1389, May 2026.Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.Lorenz Balcar, Georg Semmler, Bernhard Scheiner, Rafael Paternostro, Benedikt Simbrunner, Tina Jasmin Haunold, Mathias Jachs, Lukas Hartl, Benedikt Silvester Hofer, Nina Dominik, Michael Schwarz, Georg Kramer, Christian Sebesta, Paul Thöne, Matthias Pinter, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer +18 morewiley +1 more source